An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD

(2022) Mary P. Moore et al.   HEPATOLOGY

Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment

(2022) Peng Zhang et al.   Cell Metabolism

TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation

(2022) Ibone Labiano et al.   JOURNAL OF HEPATOLOGY

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits

(2022) Moritz Peiseler et al.   JOURNAL OF HEPATOLOGY

NAFLD and thyroid function: pathophysiological and therapeutic considerations

(2022) Erifili Hatziagelaki et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

(2022) Kiarash Riazi et al.   Lancet Gastroenterology & Hepatology

Brown adipose tissue is associated with cardiometabolic health

(2021) Tobias Becher et al.   NATURE MEDICINE

Hepatocyte-specific loss of PPARγ protects mice from NASH, and increases the therapeutic effects of rosiglitazone in the liver.

(2021) Samuel M. Lee et al.   Cellular and Molecular Gastroenterology and Hepatology

The FALCON program: Two phase 2b randomized, double-blind, placebo-controlled studies to assess the efficacy and safety of pegbelfermin in the treatment of patients with nonalcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis

(2021) Manal F. Abdelmalek et al.   Contemporary Clinical Trials

Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial

(2021) Bettina Geidl-Flueck et al.   JOURNAL OF HEPATOLOGY

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Adiponectin Alleviates Diet-induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration

(2021) Jiyoon Ryu et al.   DIABETES

Associations among adipose tissue immunology, inflammation and exosomes and insulin sensitivity in people with obesity and nonalcoholic fatty liver disease

(2021) Anja Fuchs et al.   GASTROENTEROLOGY

Increased adipose tissue fibrogenesis, not impaired expandability, is associated with nonalcoholic fatty liver disease

(2021) Joseph W. Beals et al.   HEPATOLOGY

Non-alcoholic fatty liver disease

(2021) Elizabeth E Powell et al.   LANCET

The relationship between liver histology and thyroid function tests in patients with non-alcoholic fatty liver disease (NAFLD)

(2021) Roberta D'Ambrosio et al.   PLoS One

Is there a role for neuregulin 4 in human nonalcoholic fatty liver disease?

(2021) Toon J. I. De Munck et al.   PLoS One

Serum neuregulin 4 (NRG‐4) level and non‐alcoholic fatty liver disease (NAFLD): A case‐control study

(2021) Helda Tutunchi et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

PPAR‐γ‐induced Changes in Visceral Fat and Adiponectin Levels are Associated with Improvement of Steatohepatitis in Patients with NASH

(2021) Amalia Gastaldelli et al.   LIVER INTERNATIONAL

Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial

(2021) Stephen A. Harrison et al.   NATURE MEDICINE

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

(2021) Mohammad Abu-Odeh et al.   Cell Reports

Effects of liraglutide on visceral and ectopic fat in adults with overweight and obesity at high cardiovascular risk: a randomised, double-blind, placebo-controlled, clinical trial

(2021) Ian J Neeland et al.   Lancet Diabetes & Endocrinology

Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

(2021) Vian Azzu et al.   Molecular Metabolism

Role of Leptin in Non-Alcoholic Fatty Liver Disease

(2021) Carlos Jiménez-Cortegana et al.   Biomedicines

Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis

(2021) Anca D. Petrescu et al.   AMERICAN JOURNAL OF PATHOLOGY

A new perspective on NAFLD: Focusing on lipid droplets

(2021) Eleonora Scorletti et al.   JOURNAL OF HEPATOLOGY

A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in NASH

(2021) Sven M. Francque et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice

(2021) Feng Zhang et al.   iScience

Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease

(2020) Vian Azzu et al.   GASTROENTEROLOGY

Liver‐related long‐term outcomes of thiazolidinedione use in persons with type 2 diabetes

(2020) Fu‐Shun Yen et al.   LIVER INTERNATIONAL

Metabolic flexibility is impaired in women who are pregnant and overweight/obese and related to insulin resistance and inflammation

(2020) Rachel A. Tinius et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Free fatty acid processing diverges in human pathologic insulin resistance conditions

(2020) Hilal Sekizkardes et al.   JOURNAL OF CLINICAL INVESTIGATION

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Suppressing adipocyte inflammation promotes insulin resistance in mice

(2020) Qingzhang Zhu et al.   Molecular Metabolism

Microbiomics, metabolomics, predicted metagenomics and hepatic steatosis in a population‐based study of 1355 adults

(2020) Louise JM Alferink et al.   HEPATOLOGY

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

(2020) Leiluo Geng et al.   Nature Reviews Endocrinology

Leptin decreases de novo lipogenesis in patients with lipodystrophy

(2020) Annah P. Baykal et al.   JCI Insight

TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

(2020) Aitor Esparza-Baquer et al.   GUT

Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice

(2020) Sena Bluemel et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity

(2020) Tatsuo Kawai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

INCREASED HEPATIC FAT CONTENT IN PATIENTS WITH RESISTANCE TO THYROID HORMONE BETA

(2020) Carolina Chaves et al.   THYROID

Visceral Adipose Tissue-Directed FGF21 Gene Therapy Improves Metabolic and Immune Health in BTBR Mice

(2020) Nicholas J. Queen et al.   Molecular Therapy-Methods & Clinical Development

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

(2020) Philip N. Newsome et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Phase 2 Double Blinded, Randomized Controlled Trial of Saroglitazar in Patients With Nonalcoholic Steatohepatitis

(2020) Mohammad Shadab Siddiqui et al.   Clinical Gastroenterology and Hepatology

Macrophages as Key Players during Adipose Tissue–Liver Crosstalk in Nonalcoholic Fatty Liver Disease

(2019) Hannelie Korf et al.   SEMINARS IN LIVER DISEASE

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation

(2019) Jacqueline Stöckli et al.   Molecular Metabolism

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

(2019) Martina Theresa Hackl et al.   Nature Communications

Metabolically healthy obesity: facts and fantasies

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome

(2019) Shunbun Kita et al.   JOURNAL OF CLINICAL INVESTIGATION

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

(2019) Shangang Zhao et al.   Cell Metabolism

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2019) Stephen A Harrison et al.   LANCET

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Dietary fatty acid oxidation is decreased in non‐alcoholic fatty liver disease: A palmitate breath test study

(2019) Gihan Naguib et al.   LIVER INTERNATIONAL

Neuregulin-4 is an angiogenic factor that is critically involved in the maintenance of adipose tissue vasculature

(2018) Dhite Bayu Nugroho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Response to Pioglitazone in Patients With Nonalcoholic Steatohepatitis With vs Without Type 2 Diabetes

(2018) Fernando Bril et al.   Clinical Gastroenterology and Hepatology

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

(2018) An Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Body mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity

(2018) Antônio Sérgio Barcala Jorge et al.   Obesity Research & Clinical Practice

Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance

(2018) Wenmin Xia et al.   Cell Reports

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility

(2018) Sam Virtue et al.   Cell Reports

Low serum adiponectin is a predictor of progressing to nonalcoholic fatty liver disease

(2018) Hongmei Zhang et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study

(2018) Edgar D. Charles et al.   Obesity

Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue

(2018) Vanessa Pellegrinelli et al.   Nature Communications

GLP-1 Improves Adipocyte Insulin Sensitivity Following Induction of Endoplasmic Reticulum Stress

(2018) Yaojing Jiang et al.   Frontiers in Pharmacology

Intramuscular injection of exogenous leptin induces adiposity, glucose intolerance and fatty liver by repressing the JAK2-STAT3/PI3K pathway in a rat model

(2017) Lihong Wu et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Adipose-derived exosomal MicroRNAs orchestrate gene regulation in the liver: Is this the missing link in nonalcoholic fatty liver disease?

(2017) Hannelie Korf et al.   HEPATOLOGY

Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression

(2017) Liang Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

(2017) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

PRO-C3: a new and more precise collagen marker for liver fibrosis in patients with chronic hepatitis C

(2017) Janne Fuglsang Hansen et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice

(2017) Bo Xia et al.   PLoS Genetics

Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders

(2017) Zhimin Chen et al.   Molecular Metabolism

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Serum concentrations of fibroblast growth factor 21 are elevated in patients with congenital or acquired lipodystrophy

(2016) Konstanze Miehle et al.   CYTOKINE

Lipodystrophy Due to Adipose Tissue–Specific Insulin Receptor Knockout Results in Progressive NAFLD

(2016) Samir Softic et al.   DIABETES

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Thyroid Function and the Risk of Nonalcoholic Fatty Liver Disease: The Rotterdam Study

(2016) Arjola Bano et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metformin increases hepatic leptin receptor and decreases steatosis in mice

(2016) Xuemei Tang et al.   JOURNAL OF ENDOCRINOLOGY

Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice

(2016) Abigail Wolf Greenstein et al.   JOURNAL OF ENDOCRINOLOGY

Time for Glucagon like peptide-1 receptor agonists treatment for patients with NAFLD?

(2016) Amalia Gastaldelli et al.   JOURNAL OF HEPATOLOGY

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Control of brown and beige fat development

(2016) Wenshan Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Raptor /mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease

(2016) Peter L. Lee et al.   Molecular Metabolism

Mesenteric Fat Lipolysis Mediates Obesity-associated Hepatic Steatosis and Insulin Resistance

(2015) Stephan Wueest et al.   DIABETES

Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease

(2015) Johannie du Plessis et al.   GASTROENTEROLOGY

NAFLD: A multisystem disease

(2015) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

A case–control study: Association between serum neuregulin 4 level and non-alcoholic fatty liver disease

(2015) Yi-Ning Dai et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer

(2014) Krasimira Aleksandrova et al.   HEPATOLOGY

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

(2014) Anna Secher et al.   JOURNAL OF CLINICAL INVESTIGATION

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice

(2014) Joao A. G. Duarte et al.   JOURNAL OF LIPID RESEARCH

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes

(2014) Jessica S. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis

(2014) Miyako Tanaka et al.   Nature Communications

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

(2013) Eva Morán-Salvador et al.   JOURNAL OF HEPATOLOGY

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

(2012) Y. Nio et al.   DIABETOLOGIA

Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes

(2012) Y.-S. Lee et al.   DIABETOLOGIA

Direct effect of GLP-1 infusion on endogenous glucose production in humans

(2012) M. Seghieri et al.   DIABETOLOGIA

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Non-alcoholic fatty liver disease across the spectrum of hypothyroidism

(2012) Goh Eun Chung et al.   JOURNAL OF HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Metabolic effects of muraglitazar in type 2 diabetic subjects

(2011) M. Fernandez et al.   DIABETES OBESITY & METABOLISM

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21)in Vivo

(2011) ffolliott M. Fisher et al.   ENDOCRINOLOGY

Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis

(2011) Srinivasan Dasarathy et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Elevated systemic monocyte chemoattractrant protein-1 in hepatic steatosis without significant hepatic inflammation

(2011) Georgi Kirovski et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

(2011) Gianluca Svegliati-Baroni et al.   LIVER INTERNATIONAL

Adipokines as novel biomarkers and regulators of the metabolic syndrome

(2010) Yingfeng Deng et al.   Annals of the New York Academy of Sciences

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

(2010) F. K. Huynh et al.   DIABETES

Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity: A Driver for Ectopic Fat Deposition?

(2010) S. E. McQuaid et al.   DIABETES

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

(2010) Nitika Arora Gupta et al.   HEPATOLOGY

Adiponectin activation of AMPK disrupts leptin-mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS-3)

(2010) Jeffrey A. Handy et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine–choline-deficient diet

(2010) Karen M Kassel et al.   LABORATORY INVESTIGATION

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Decreased whole body lipolysis as a mechanism of the lipid-lowering effect of pioglitazone in type 2 diabetic patients

(2009) Amalia Gastaldelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway

(2009) Motoharu Awazawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPAR γ is highly expressed in F4/80hi adipose tissue macrophages and dampens adipose-tissue inflammation

(2009) Josep Bassaganya-Riera et al.   CELLULAR IMMUNOLOGY

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Kupffer Cells Mediate Leptin-Induced Liver Fibrosis

(2009) Jianhua Wang et al.   GASTROENTEROLOGY

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

(2009) Amalia Gastaldelli et al.   HEPATOLOGY

Low Serum Adiponectin Levels Are Predictive of Advanced Hepatic Fibrosis in Patients With NAFLD

(2009) Savvoula Savvidou et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms

(2009) O. Araki et al.   MOLECULAR ENDOCRINOLOGY

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

(2009) Shigeki Sugii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

(2008) Thien T. Tran et al.   Cell Metabolism

Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate

(2008) J. E. Galgani et al.   DIABETES

FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity

(2008) Peter Arner et al.   FEBS LETTERS

Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects

(2008) Kevin M. Korenblat et al.   GASTROENTEROLOGY

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

It's Not How Fat You Are, It's What You Do with It That Counts

(2008) Samuel Virtue et al.   PLOS BIOLOGY

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY