FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

(2020) Susanne Keipert et al.   Nature Communications

The autocrine role of FGF21 in cultured adipocytes

(2020) Sarah Justesen et al.   BIOCHEMICAL JOURNAL

Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure

(2019) Magdalene Ameka et al.   Scientific Reports

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

(2019) Steven A. Kliewer et al.   Cell Metabolism

FGF21 as Modulator of Metabolism in Health and Disease

(2019) Caterina Tezze et al.   Frontiers in Physiology

Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

(2019) Ziguo Song et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Browning of white adipose tissue induced by the ß3 agonist CL-316,243 after local and systemic treatment - PK-PD relationship

(2018) Wojciech Danysz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

(2018) Peng Zhao et al.   CELL

Fat Body Biology in the Last Decade

(2018) Sheng Li et al.   Annual Review of Entomology

Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition

(2017) Zhe Xu et al.   Scientific Reports

Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis

(2016) Lucas D. BonDurant et al.   Annual Review of Nutrition

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Fibroblast growth factor 21 night watch: advances and uncertainties in the field

(2016) A. Kharitonenkov et al.   JOURNAL OF INTERNAL MEDICINE

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ

(2016) Zhifeng Huang et al.   MOLECULAR CELL

Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism

(2016) Kathrina L. Marcelo et al.   MOLECULAR ENDOCRINOLOGY

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis

(2016) Kathleen R. Markan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation

(2016) Jieun Lee et al.   Cell Reports

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

(2015) Murielle M. Véniant et al.   Cell Metabolism

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine

(2015) Paul Cohen et al.   DIABETES

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

(2015) Nicholas Douris et al.   ENDOCRINOLOGY

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

(2015) Ricardo J. Samms et al.   Cell Reports

Unlock the Thermogenic Potential of Adipose Tissue: Pharmacological Modulation and Implications for Treatment of Diabetes and Obesity

(2015) Xiao-Rong Peng et al.   Frontiers in Endocrinology

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting

(2014) Q. Liang et al.   DIABETES

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

G Protein-Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors

(2013) Anna Eisenstein et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Development of small-molecule inhibitors targeting adipose triglyceride lipase

(2013) Nicole Mayer et al.   Nature Chemical Biology

Adrenergic pathway activation enhances brown adipose tissue metabolism: A [18F]FDG PET/CT study in mice

(2013) M. Reza Mirbolooki et al.   NUCLEAR MEDICINE AND BIOLOGY

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

(2012) M. J. Potthoff et al.   GENES & DEVELOPMENT

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

(2011) Xuan Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

The phospholipase C inhibitor U-73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle

(2010) D MacMillan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation

(2009) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling pathways mediating β3-adrenergic receptor-induced production of interleukin-6 in adipocytes

(2009) Inna E. Tchivileva et al.   MOLECULAR IMMUNOLOGY

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

FGF21 induces PGC-1  and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

(2009) M. J. Potthoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation

(2008) Nilton A. Brito et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism