Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity

Subcutaneous Adipose Tissue and Systemic Inflammation are Associated with Peripheral But Not Hepatic Insulin Resistance in Humans

(2019) Birgitta W. van der Kolk et al.   DIABETES

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity

(2018) Jong Hun Kim et al.   FASEB JOURNAL

Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C

(2018) S Becerril et al.   INTERNATIONAL JOURNAL OF OBESITY

Hyperhomocysteinemia Promotes Insulin Resistance and Adipose Tissue Inflammation in PCOS Mice Through Modulating M2 Macrophage Polarization via Estrogen Suppression

(2017) Xinyu Qi et al.   ENDOCRINOLOGY

Role of A 1 and A 2A adenosine receptor agonists in adipose tissue inflammation induced by obesity in mice

(2017) Caroline Candida DeOliveira et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

The short-term and long-term effects of bariatric/metabolic surgery on subcutaneous adipose tissue inflammation in humans

(2017) Derek K. Hagman et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice

(2017) Latha Muniappan et al.   Scientific Reports

The CCR2 Inhibitor Propagermanium Attenuates Diet-Induced Insulin Resistance, Adipose Tissue Inflammation and Non-Alcoholic Steatohepatitis

(2017) Petra Mulder et al.   PLoS One

Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity

(2016) Faidon Magkos et al.   Cell Metabolism

Obesity but not high-fat diet impairs lymphatic function

(2016) G D García Nores et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

ATP-Induced Inflammation Drives Tissue-Resident Th17 Cells in Metabolically Unhealthy Obesity

(2016) Julieta B. Pandolfi et al.   JOURNAL OF IMMUNOLOGY

‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue

(2016) Laura M. Pérez et al.   JOURNAL OF PHYSIOLOGY-LONDON

Obesity-induced lymphatic dysfunction is reversible with weight loss

(2016) Matthew D. Nitti et al.   JOURNAL OF PHYSIOLOGY-LONDON

Osteopontin is a key player for local adipose tissue macrophage proliferation in obesity

(2016) Matteo Tardelli et al.   Molecular Metabolism

Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation

(2016) Akinori Sato et al.   PLoS One

Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice

(2016) Valeriy A. Poroyko et al.   Scientific Reports

Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages

(2015) Ryan G. Snodgrass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells

(2015) Emma L. Kuan et al.   JOURNAL OF IMMUNOLOGY

Patchy progress on obesity prevention: emerging examples, entrenched barriers, and new thinking

(2015) Christina A Roberto et al.   LANCET

Ageing, adipose tissue, fatty acids and inflammation

(2014) Chathyan Pararasa et al.   BIOGERONTOLOGY

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

(2014) Yun Sok Lee et al.   CELL

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Effect of 8 Weeks of Overfeeding on Ectopic Fat Deposition and Insulin Sensitivity: Testing the “Adipose Tissue Expandability” Hypothesis

(2014) Darcy L. Johannsen et al.   DIABETES CARE

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity

(2014) Bhama Ramkhelawon et al.   NATURE MEDICINE

Chronic High-Fat Diet Impairs Collecting Lymphatic Vessel Function in Mice

(2014) Katrin S. Blum et al.   PLoS One

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity

(2013) Ippei Shimizu et al.   Cell Metabolism

Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance

(2013) Emily K. Anderson et al.   DIABETES

Programmed Cell Death-4 Deficiency Prevents Diet-Induced Obesity, Adipose Tissue Inflammation, and Insulin Resistance

(2013) Q. Wang et al.   DIABETES

Induction of Cytosolic Phospholipase A 2 α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding

(2013) Nurit Hadad et al.   DIABETES

Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

(2013) S. Fujisaka et al.   DIABETOLOGIA

The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis

(2013) Gitanjali M. Singh et al.   PLoS One

Obesity Impairs Lymphatic Fluid Transport and Dendritic Cell Migration to Lymph Nodes

(2013) Evan S. Weitman et al.   PLoS One

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

(2013) M. Aouadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Concept of Normal Weight Obesity

(2013) Estefania Oliveros et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

(2012) M. Stefanovic-Racic et al.   DIABETES

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

TNF-α Up-Regulates Protein Level and Cell Surface Expression of the Leptin Receptor by Stimulating Its Export via a PKC-Dependent Mechanism

(2012) Lixia Gan et al.   ENDOCRINOLOGY

Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?

(2012) N Arngrim et al.   INTERNATIONAL JOURNAL OF OBESITY

Increased Tenascin C And Toll-Like Receptor 4 Levels in Visceral Adipose Tissue as a Link between Inflammation and Extracellular Matrix Remodeling in Obesity

(2012) Victoria Catalán et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques

(2012) Janine M van Gils et al.   NATURE IMMUNOLOGY

Storage of Circulating Free Fatty Acid in Adipose Tissue of Postabsorptive Humans: Quantitative Measures and Implications for Body Fat Distribution

(2011) C. Koutsari et al.   DIABETES

Hematopoietic Cell-Restricted Deletion of CD36 Reduces High-Fat Diet-Induced Macrophage Infiltration and Improves Insulin Signaling in Adipose Tissue

(2011) H. T. Nicholls et al.   DIABETES

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

(2011) M. Spite et al.   JOURNAL OF IMMUNOLOGY

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(2011) Victoria Catalan et al.   MOLECULAR MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients

(2011) Victoria Catalán et al.   Surgery for Obesity and Related Diseases

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Short-Term Overfeeding May Induce Peripheral Insulin Resistance Without Altering Subcutaneous Adipose Tissue Macrophages in Humans

(2010) C. S. Tam et al.   DIABETES

Adipose Tissue Endothelial Cells From Obese Human Subjects: Differences Among Depots in Angiogenic, Metabolic, and Inflammatory Gene Expression and Cellular Senescence

(2010) A. Villaret et al.   DIABETES

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

The Portal Theory Supported by Venous Drainage-Selective Fat Transplantation

(2010) J. M. Rytka et al.   DIABETES

Dietary intervention-induced weight loss decreases macrophage content in adipose tissue of obese women

(2010) M Kováčiková et al.   INTERNATIONAL JOURNAL OF OBESITY

Chemerin, a Novel Adipokine in the Regulation of Angiogenesis

(2010) Kiymet Bozaoglu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Effects of Weight Loss and Gastric Banding on the Innate and Adaptive Immune System in Type 2 Diabetes and Prediabetes

(2010) A. Viardot et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

(2010) Aliki Kosteli et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast cells, macrophages, and crown-like structures distinguish subcutaneous from visceral fat in mice

(2010) Mehmet M. Altintas et al.   JOURNAL OF LIPID RESEARCH

Body-Mass Index and Mortality among 1.46 Million White Adults

(2010) Amy Berrington de Gonzalez et al.   NEW ENGLAND JOURNAL OF MEDICINE

Organotypic culture of human bone marrow adipose tissue

(2010) Kazuyoshi Uchihashi et al.   PATHOLOGY INTERNATIONAL

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

(2009) S. Fujisaka et al.   DIABETES

Receptors for Tumor Necrosis Factor-α Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status

(2009) Nathalie Pamir et al.   ENDOCRINOLOGY

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue

(2009) R W O'Rourke et al.   INTERNATIONAL JOURNAL OF OBESITY

Human Adipose Tissue Macrophages: M1 and M2 Cell Surface Markers in Subcutaneous and Omental Depots and after Weight Loss

(2009) Judith Aron-Wisnewsky et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Calprotectin — A Novel Marker of Obesity

(2009) Ole Hartvig Mortensen et al.   PLoS One

Inflammation is associated with a decrease of lipogenic factors in omental fat in women

(2008) Odile Poulain-Godefroy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Macrophage Content in Subcutaneous Adipose Tissue: Associations With Adiposity, Age, Inflammatory Markers, and Whole-Body Insulin Action in Healthy Pima Indians

(2008) E. Ortega Martinez de Victoria et al.   DIABETES

Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response

(2008) M. Pasarica et al.   DIABETES

Synthetic chemerin-derived peptides suppress inflammation through ChemR23

(2008) Jenna L. Cash et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

(2008) I. Murano et al.   JOURNAL OF LIPID RESEARCH