Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese mice

Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model

(2021) Xiankang Fang et al.   LIFE SCIENCES

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

(2021) Pauline Morigny et al.   Nature Reviews Endocrinology

Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue

(2020) Biyu Hou et al.   LIFE SCIENCES

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

(2020) Samantha M. Fortin et al.   Science Translational Medicine

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

(2020) Alexander Yang et al.   BIOCHEMICAL JOURNAL

Lipidomics of brown and white adipose tissue: Implications for energy metabolism

(2020) Luiz O. Leiria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramides in Metabolism: Key Lipotoxic Players

(2020) Bhagirath Chaurasia et al.   Annual Review of Physiology

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

(2019) Michal Grzybek et al.   Molecular Metabolism

Glucagon-Like Peptide-1 Receptor Analogues in Type 2 Diabetes: Their Use and Differential Features

(2019) Katherine A. Lyseng-Williamson   CLINICAL DRUG INVESTIGATION

Cold-induced lipid dynamics and transcriptional programs in white adipose tissue

(2019) Ziye Xu et al.   BMC BIOLOGY

Role of Ceramidases in Sphingolipid Metabolism and Human Diseases

(2019) Farzana Parveen et al.   Cells

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates

(2018) Ralf Elvert et al.   DIABETES OBESITY & METABOLISM

Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose

(2018) Jordi Merino et al.   DIABETOLOGIA

Triglyceride profiling in adipose tissues from obese insulin sensitive, insulin resistant and type 2 diabetes mellitus individuals

(2018) Haya Al-Sulaiti et al.   Journal of Translational Medicine

Mild Suppression of Hyperinsulinemia to Treat Obesity and Insulin Resistance

(2018) Melissa M. Page et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity

(2018) Shin J. Lee et al.   Molecular Metabolism

One-year follow-up on liraglutide treatment for prediabetes and overweight/obesity in clozapine- or olanzapine-treated patients

(2018) C. K. Svensson et al.   ACTA PSYCHIATRICA SCANDINAVICA

Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial

(2018) Cristina Razquin et al.   DIABETES CARE

Recombinant human glucagon-like peptide-1 protects against chronic intermittent hypoxia by improving myocardial energy metabolism and mitochondrial biogenesis

(2018) Lichan Tao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The effects of liraglutide in mice with diet-induced obesity studied by metabolomics

(2017) Martina Bugáňová et al.   JOURNAL OF ENDOCRINOLOGY

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

(2017) Francis J. May et al.   Cell Reports

Glucagon-like peptide-1 mimetics, optimal for Asian type 2 diabetes patients with and without overweight/obesity: meta-analysis of randomized controlled trials

(2017) Fang Zhang et al.   Scientific Reports

GLP-1 and weight loss: unraveling the diverse neural circuitry

(2016) Scott E. Kanoski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators

(2016) Juan Decara et al.   BIOFACTORS

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy

(2016) Lydia Lynch et al.   Cell Metabolism

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

(2016) Bhagirath Chaurasia et al.   Cell Metabolism

Lipidomics for studying metabolism

(2016) Xianlin Han   Nature Reviews Endocrinology

Glucagon-like peptide-1 regulates calcium homeostasis and electrophysiological activities of HL-1 cardiomyocytes

(2016) Jen-Hung Huang et al.   PEPTIDES

Adiponectin, the past two decades

(2016) Zhao V. Wang et al.   Journal of Molecular Cell Biology

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

(2015) Ana Paula Arruda et al.   Cell Metabolism

Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling

(2015) Charlotte C Ronveaux et al.   JOURNAL OF NUTRITION

RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold

(2015) Ann-Britt Marcher et al.   Cell Reports

Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat

(2015) Miguel López et al.   Adipocyte

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells

(2014) Daisuke Hishikawa et al.   JOURNAL OF LIPID RESEARCH

Regulation of adipocyte lipolysis

(2014) Gema Frühbeck et al.   NUTRITION RESEARCH REVIEWS

Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism

(2014) Nadia M. Krasner et al.   PLoS One

Combating the dual burden: therapeutic targeting of common pathways in obesity and type 2 diabetes

(2014) André J Scheen et al.   Lancet Diabetes & Endocrinology

Mechanisms underlying current and future anti-obesity drugs

(2013) Roger A.H. Adan   TRENDS IN NEUROSCIENCES

GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

(2012) Juris J. Meier   Nature Reviews Endocrinology

Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women

(2011) A. Veilleux et al.   DIABETES

Banting Lecture 2011: Hyperinsulinemia: Cause or Consequence?

(2011) B. E. Corkey   DIABETES

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity

(2010) J. Hoffstedt et al.   DIABETOLOGIA

A Combined Transcriptomics and Lipidomics Analysis of Subcutaneous, Epididymal and Mesenteric Adipose Tissue Reveals Marked Functional Differences

(2010) Robert Caesar et al.   PLoS One

GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

(2009) M. H. Noyan-Ashraf et al.   DIABETES

Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study

(2008) Daniel J Drucker et al.   LANCET