TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation

Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators

(2021) Jinho Seo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Intestinal microbiome‐macrophage crosstalk contributes to cholestatic liver disease by promoting intestinal permeability

(2020) Anna Isaacs‐Ten et al.   HEPATOLOGY

TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

(2020) Aitor Esparza-Baquer et al.   GUT

Cholangiocyte pathobiology

(2019) Jesus M. Banales et al.   Nature Reviews Gastroenterology & Hepatology

The gut microbial influence on cholestatic liver disease

(2019) Martin Kummen et al.   LIVER INTERNATIONAL

Drug Therapies for Chronic Cholestatic Liver Diseases

(2019) Martin Wagner et al.   Annual Review of Pharmacology and Toxicology

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Cell-specific regulatory effects of CXCR2 on cholestatic liver injury

(2019) Takanori Konishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammation and Cell Death During Cholestasis: The Evolving Role of Bile Acids

(2019) Benjamin L. Woolbright et al.   GENE EXPRESSION

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Primary biliary cholangitis: pathogenesis and therapeutic opportunities

(2019) Aliya F. Gulamhusein et al.   Nature Reviews Gastroenterology & Hepatology

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

(2018) Maria J Perugorria et al.   GUT

Anti-inflammatory properties of ursodeoxycholyl lysophosphatidylethanolamide in endotoxin-mediated inflammatory liver injury

(2018) Johannes Maximilian Ludwig et al.   PLoS One

Ductular reaction in liver diseases: pathological mechanisms and translational significances

(2018) Keisaku Sato et al.   HEPATOLOGY

Primary biliary cholangitis: a tale of epigenetically-induced secretory failure?

(2018) Pedro M. Rodrigues et al.   JOURNAL OF HEPATOLOGY

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

(2017) Ruqi Tang et al.   GUT

TREM2-Ligand Interactions in Health and Disease

(2017) Daniel L. Kober et al.   JOURNAL OF MOLECULAR BIOLOGY

Management of cholestatic disease in 2017

(2017) Elsemieke de Vries et al.   LIVER INTERNATIONAL

Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD

(2016) João Sabino et al.   GUT

Activation of necroptosis in human and experimental cholestasis

(2016) Marta B Afonso et al.   Cell Death & Disease

Early Molecular Stratification of High-risk Primary Biliary Cholangitis

(2016) Claire Hardie et al.   EBioMedicine

The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats

(2015) Len Verbeke et al.   AMERICAN JOURNAL OF PATHOLOGY

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

(2015) Jochen Walter   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis

(2014) James H. Tabibian et al.   HEPATOLOGY

Biliary repair and carcinogenesis are mediated by IL-33–dependent cholangiocyte proliferation

(2014) Jun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-33 Promotes Disease Progression in Patients with Primary Biliary Cirrhosis

(2014) Yongqiang Sun et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Tumor progression locus 2/Cot is required for activation of extracellular regulated kinase in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice

(2012) Maria J. Perugorria et al.   HEPATOLOGY

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

(2011) Ekihiro Seki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Current consensus on the management of primary sclerosing cholangitis

(2011) K. Wiencke et al.   Clinics and Research in Hepatology and Gastroenterology

Bicarbonate secretion of mouse cholangiocytes involves Na+-HCO3−cotransport in addition to Na+-independent Cl−/HCO3−exchange

(2009) Iker Uriarte et al.   HEPATOLOGY

From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

(2008) Omar Sharif et al.   IMMUNOBIOLOGY