TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration

(2019) Ximeng Han et al.   Stem Cell Reports

TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway

(2019) Wenqing Tang et al.   Oncogenesis

Contributions of Fibroblasts, Extracellular Matrix, Stiffness, and Mechanosensing to Hepatocarcinogenesis

(2019) Aveline Filliol et al.   SEMINARS IN LIVER DISEASE

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

(2019) Lichun Ma et al.   CANCER CELL

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

(2018) Jacquelyn O. Russell et al.   Annual Review of Pathology-Mechanisms of Disease

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

(2018) Maria J Perugorria et al.   GUT

High TREM2 expression correlates with poor prognosis in gastric cancer

(2018) Xiaojing Zhang et al.   HUMAN PATHOLOGY

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research

(2018) Zachary J. Brown et al.   Nature Reviews Gastroenterology & Hepatology

Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma

(2018) Iftikhar Ali Khawar et al.   NEOPLASIA

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

(2018) Marcus Grohmann et al.   CELL

Wnt–β-catenin signalling in liver development, health and disease

(2018) Maria J. Perugorria et al.   Nature Reviews Gastroenterology & Hepatology

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

The Dynamic Roles of Mesenchymal Stem Cells in Colon Cancer

(2018) Shan Wang et al.   Canadian Journal of Gastroenterology and Hepatology

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

The lipid-sensor TREM2 aggravates disease in a model of LCMV-induced hepatitis

(2017) Lindsay Kosack et al.   Scientific Reports

Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo

(2017) Hong-Ryul Jung et al.   Scientific Reports

Depletion of the triggering receptor expressed on myeloid cells 2 inhibits progression of renal cell carcinoma via regulating related protein expression and PTEN-PI3K/Akt pathway

(2016) Haojie Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Liver regeneration microenvironment of hepatocellular carcinoma for prevention and therapy

(2016) Hanmin Li et al.   Oncotarget

TREM-2 serves as a negative immune regulator through Syk pathway in an IL-10 dependent manner in lung cancer

(2016) Yinan Yao et al.   Oncotarget

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

Effect of liver regeneration on malignant hepatic tumors

(2016) Ji-Hua Shi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatic stellate cells: central modulators of hepatic carcinogenesis

(2015) Alexandra I Thompson et al.   BMC GASTROENTEROLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

(2015) C. L. Wilson et al.   Nature Communications

Overexpression of TREM2 enhances glioma cell proliferation and invasion: a therapeutic target in human glioma

(2015) Xiao-Qiang Wang et al.   Oncotarget

N-diethylnitrosamine mouse hepatotoxicity: Time-related effects on histology and oxidative stress

(2014) Nuno Paula Santos et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma: An intricate pathway

(2014) Romilda Cardin   WORLD JOURNAL OF GASTROENTEROLOGY

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Estimation of rat mammary tumor volume using caliper and ultrasonography measurements

(2013) Ana Faustino-Rocha et al.   LAB ANIMAL

Role of innate immunity in the development of hepatocellular carcinoma

(2013) Rajagopal N Aravalli   WORLD JOURNAL OF GASTROENTEROLOGY

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma

(2012) Juan Wu et al.   CANCER RESEARCH

TREM2 and  -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis

(2012) K. Otero et al.   JOURNAL OF IMMUNOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

(2011) Terence Kin Wah Lee et al.   Cell Stem Cell

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

(2011) Mohammad R Ebrahimkhani et al.   NATURE MEDICINE

Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks

(2010) H. Barash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets

(2010) Ju Dong Yang et al.   SEMINARS IN CANCER BIOLOGY

Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma

(2009) Thomas Amann et al.   CANCER SCIENCE

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

(2008) Omar Sharif et al.   IMMUNOBIOLOGY