Decoding Strategies to Evade Immunoregulators Galectin-1, -3, and -9 and Their Ligands as Novel Therapeutics in Cancer Immunotherapy

Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden

(2022) Julia Femel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment

(2022) Simone Kloch Bendtsen et al.   OncoImmunology

Changes in T-cell subsets and clonal repertoire during chemoimmunotherapy with pembrolizumab and paclitaxel or capecitabine for metastatic triple-negative breast cancer

(2022) Brie Chun et al.   Journal for ImmunoTherapy of Cancer

Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner

(2022) Adel Abo Mansour et al.   BIOMEDICINE & PHARMACOTHERAPY

Hypoxia controls the glycome signature and galectin-8 – ligand axis to promote pro-tumorigenic properties of metastatic melanoma.

(2022) Asmi Chakraborty et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Galectin-9 as a biomarker of disease severity

(2021) Preeti Moar et al.   CELLULAR IMMUNOLOGY

Genetic glycoengineering in mammalian cells

(2021) Yoshiki Narimatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

(2021) Riyao Yang et al.   Nature Communications

An updated patent review of galectin-1 and galectin-3 inhibitors and their potential therapeutic applications (2016–present)

(2021) Aaftaab Sethi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression

(2021) Seok-Jun Kim et al.   Gastric Cancer

Selective 13 C‐Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins

(2021) María J. Moure et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma

(2021) Laura Liebscher et al.   CANCER LETTERS

Selectively Deoxyfluorinated N ‐Acetyllactosamine Analogues as 19 F NMR Probes to Study Carbohydrate‐Galectin Interactions

(2021) Martin Kurfiřt et al.   CHEMISTRY-A EUROPEAN JOURNAL

Immunoprotective neo-glycoproteins: Chemoenzymatic synthesis of multivalent glycomimetics for inhibition of cancer-related galectin-3

(2021) Viktoria Heine et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting galectins in T cell-based immunotherapy within tumor microenvironment

(2021) Qiu-Yang Jin et al.   LIFE SCIENCES

Galectin‐9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin‐dependent manner

(2021) Asif J. Iqbal et al.   FASEB JOURNAL

Galectins as Emerging Glyco-Checkpoints and Therapeutic Targets in Glioblastoma

(2021) Guillermo A. Videla-Richardson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

(2020) Xin He et al.   BLOOD

β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

(2020) Silvia Giannini et al.   Nature Communications

Computational Prediction and Validation of Tumor-Associated Neoantigens

(2020) Vladimir Roudko et al.   Frontiers in Immunology

Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival

(2020) Yu-Li Su et al.   Cells

Impact of Galectins in Resistance to Anticancer Therapies

(2020) Pilar Navarro et al.   CLINICAL CANCER RESEARCH

Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy

(2020) Simone Nüssing et al.   Frontiers in Immunology

Structures and mechanism of human glycosyltransferase β1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), an important player in immune homeostasis

(2020) Yue Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways

(2020) Asmi Chakraborty et al.   JOURNAL OF AUTOIMMUNITY

Immunogenomic analysis reveals LGALS1 contributes to the immune heterogeneity and immunosuppression in glioma

(2019) Qun Chen et al.   INTERNATIONAL JOURNAL OF CANCER

The First Step in Adoptive Cell Immunotherapeutics: Assuring Cell Delivery via Glycoengineering

(2019) Robert Sackstein   Frontiers in Immunology

Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways

(2019) Kamil Seyrek et al.   CELL DEATH AND DIFFERENTIATION

Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding

(2019) Nandini Mondal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance

(2019) Dhanya K. Nambiar et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

(2019) Li Yang et al.   Journal of Hematology & Oncology

Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression

(2019) María Romina Girotti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sialic acid blockade suppresses tumor growth by enhancing T cell-mediated tumor immunity

(2018) Christian Büll et al.   CANCER RESEARCH

Glycan-directed CAR-T cells

(2018) Catharina Steentoft et al.   GLYCOBIOLOGY

Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling

(2018) Ladislav Bumba et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Galectins in Tumors and in Clinical Immunotherapy

(2018) Feng-Cheng Chou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galectin Targeted Therapy in Oncology: Current Knowledge and Perspectives

(2018) Kamil Wdowiak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD206-positive myeloid cells bind galectin-9 and promote a tumor-supportive microenvironment

(2018) Elizabeth Ann L Enninga et al.   JOURNAL OF PATHOLOGY

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk

(2018) Carlos A. Orozco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic control of T cell immune response through glycans in inflammatory bowel disease

(2018) Ana M. Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation

(2018) Marta A. Toscano et al.   TRENDS IN MOLECULAR MEDICINE

The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment

(2018) Mohammad Farhad et al.   OncoImmunology

Anti-CTLA-4 based therapy elicits humoral immunity to galectin-3 in patients with metastatic melanoma

(2018) Xinqi Wu et al.   OncoImmunology

Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

(2018) Jenna Geddes Sweeney et al.   Nature Communications

Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans

(2018) N. Giovannone et al.   Nature Communications

The role of galectin-3 in heart failure and cardiovascular disease

(2018) Xiao Zhong et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin–glycan specificities in a natural context

(2018) Mathias Ingemann Nielsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans

(2018) Nicholas Giovannone et al.   Frontiers in Immunology

Glycans as Key Checkpoints of T Cell Activity and Function

(2018) Márcia S. Pereira et al.   Frontiers in Immunology

A Single-Step Chemoenzymatic Reaction for the Construction of Antibody–Cell Conjugates

(2018) Jie Li et al.   ACS Central Science

Galectin-9 binds to O-glycans on protein disulfide isomerase

(2017) Katrin Schaefer et al.   GLYCOBIOLOGY

Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation

(2017) Victoria Sundblad et al.   JOURNAL OF IMMUNOLOGY

Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

(2017) Donnele Daley et al.   NATURE MEDICINE

Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

(2017) Monica Gordon-Alonso et al.   Nature Communications

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

(2017) Martin Lauss et al.   Nature Communications

The N-terminal tail coordinates with carbohydrate recognition domain to mediate galectin-3 induced apoptosis in T cells

(2017) Huiting Xue et al.   Oncotarget

Combined Anti-VEGF and Anti–CTLA-4 Therapy Elicits Humoral Immunity to Galectin-1 Which Is Associated with Favorable Clinical Outcomes

(2017) Xinqi Wu et al.   Cancer Immunology Research

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

(2017) Irene Scarfò et al.   Journal for ImmunoTherapy of Cancer

Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms

(2016) J. M. Lykken et al.   BLOOD

Galectins: their network and roles in immunity/tumor growth control

(2016) Herbert Kaltner et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A key role for galectin-1 in sprouting angiogenesis revealed by novel rationally designed antibodies

(2016) Judy R. van Beijnum et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular Basis for Recognition of the Cancer Glycobiomarker, LacdiNAc (GalNAc[β1→4]GlcNAc), byWisteria floribundaAgglutinin

(2016) Omid Haji-Ghassemi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-9: From cell biology to complex disease dynamics

(2016) Sebastian John et al.   JOURNAL OF BIOSCIENCES

Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells

(2016) Brad Dykstra et al.   STEM CELLS

Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signaling

(2016) P-F Zhang et al.   Cell Death & Disease

O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer

(2016) Sofia N. Santos et al.   Oncotarget

Using CRISPR-Cas9 to quantify the contributions of O-glycans, N-glycans and Glycosphingolipids to human leukocyte-endothelium adhesion

(2016) Gino Stolfa et al.   Scientific Reports

Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo

(2015) KOJI FUJITA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Galectin-1 Regulates Tissue Exit of Specific Dendritic Cell Populations

(2015) Sandra Thiemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential

(2015) Erika M. Yazawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Engineered CHO cells for production of diverse, homogeneous glycoproteins

(2015) Zhang Yang et al.   NATURE BIOTECHNOLOGY

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

(2015) Alexander J. Davenport et al.   Cancer Immunology Research

Galectin 1 Proangiogenic and Promigratory Effects in the Hs683 Oligodendroglioma Model Are Partly Mediated through the Control of BEX2 Expression

(2015) Marie Le Mercier et al.   NEOPLASIA

Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells

(2014) Chuan Wu et al.   IMMUNITY

Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions

(2014) K. Nagahara et al.   JOURNAL OF IMMUNOLOGY

Acquired and intrinsic resistance in cancer immunotherapy

(2014) Sander Kelderman et al.   Molecular Oncology

Tumour heterogeneity and the evolution of polyclonal drug resistance

(2014) Rebecca A. Burrell et al.   Molecular Oncology

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 in tumor biology: A jack of multiple trades

(2013) Roy Heusschen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Unraveling galectin-1 as a novel therapeutic target for cancer

(2013) Lucile Astorgues-Xerri et al.   CANCER TREATMENT REVIEWS

Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity

(2013) Tina Verschuere et al.   INTERNATIONAL JOURNAL OF CANCER

Galectin-3 Accelerates the Progression of Oral Tongue Squamous Cell Carcinoma via a Wnt/β-catenin-Dependent Pathway

(2013) Li-Ping Wang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

(2013) L.-C. S. Wang et al.   Cancer Immunology Research

Galectin-3 binds to CD45 on diffuse large B-cell lymphoma cells to regulate susceptibility to cell death

(2012) M. C. Clark et al.   BLOOD

Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease

(2012) T. Dalotto-Moreno et al.   CANCER RESEARCH

Inhibiting galectin-1 reduces murine lung metastasis with increased CD4+ and CD8+ T cells and reduced cancer cell adherence

(2012) Koichi Ito et al.   CLINICAL & EXPERIMENTAL METASTASIS

Overexpression of galectin-3 enhances migration of colon cancer cells related to activation of the K-Ras–Raf–Erk1/2 pathway

(2012) Keng-Liang Wu et al.   JOURNAL OF GASTROENTEROLOGY

Galectin-1 Triggers an Immunoregulatory Signature in Th Cells Functionally Defined by IL-10 Expression

(2012) F. Cedeno-Laurent et al.   JOURNAL OF IMMUNOLOGY

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

Glycoengineering of HCELL, the Human Bone Marrow Homing Receptor: Sweetly Programming Cell Migration

(2011) Robert Sackstein   ANNALS OF BIOMEDICAL ENGINEERING

Successful treatment of metastatic melanoma by adoptive transfer of blood-derived polyclonal tumor-specific CD4+ and CD8+ T cells in combination with low-dose interferon-alpha

(2011) Els M. E. Verdegaal et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Galectin-1 research in T cell immunity: Past, present and future

(2011) Filiberto Cedeno-Laurent et al.   CLINICAL IMMUNOLOGY

Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire ofN- andO-Glycans without Direct Incorporation

(2011) Steven R. Barthel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor Immunity

(2011) Filiberto Cedeno-Laurent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice

(2010) N. Demotte et al.   CANCER RESEARCH

Galectin multimerization and lattice formation are regulated by linker region structure

(2010) L. A. Earl et al.   GLYCOBIOLOGY

Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response

(2010) Anna I. Markowska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells

(2010) V. Dardalhon et al.   JOURNAL OF IMMUNOLOGY

Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death

(2010) B Brandt et al.   Cell Death & Disease

Role of apoptosis resistance in immune evasion and metastasis of colorectal cancer

(2010) Kebin Liu   World Journal of Gastrointestinal Oncology

Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration

(2009) Robert Sackstein   IMMUNOLOGICAL REVIEWS

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices

(2008) A. Nobumoto et al.   GLYCOBIOLOGY

Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways

(2008) Shuguang Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines

(2008) Tae-Young Jung et al.   JOURNAL OF NEUROSURGERY

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE