Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment
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Title
Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment
Authors
Keywords
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Journal
Journal of Hematology & Oncology
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-11-27
DOI
10.1186/s13045-019-0804-8
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Note: Only part of the references are listed.- IL-10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF-κB/Notch1 pathway in non-small cell lung cancer
- (2019) Li Yang et al. INTERNATIONAL JOURNAL OF CANCER
- Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors
- (2019) Kyung Hae Jung et al. CLINICAL CANCER RESEARCH
- Macrophage-derived CCL22 promotes an immunosuppressive tumor microenvironment via IL-8 in malignant pleural effusion
- (2019) Dong Wang et al. CANCER LETTERS
- Combinatory effects of vaccinia virus VG9 and the STAT3 inhibitor Stattic on cancer therapy
- (2019) Runlin Yang et al. ARCHIVES OF VIROLOGY
- Efficacy and Safety of BRAF Inhibitors With or Without MEK Inhibitors in BRAF-Mutant Advanced Non–Small-Cell Lung Cancer: Findings From a Real-Life Cohort
- (2019) Elizabeth Dudnik et al. Clinical Lung Cancer
- Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation
- (2019) Lisha Ai et al. Molecular Cancer
- Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity
- (2019) Lifeng Li et al. Molecular Cancer
- Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma
- (2019) Paolo Antonio Ascierto et al. NATURE MEDICINE
- Co-delivery of DOX and PDTC by pH-sensitive nanoparticles to overcome multidrug resistance in breast cancer
- (2019) Xu Cheng et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1
- (2018) Helena J. Janse van Rensburg et al. CANCER RESEARCH
- Oncogenic BRAFV600E governs regulatory T cell recruitment during melanoma tumorigenesis
- (2018) Tamer B Shabaneh et al. CANCER RESEARCH
- Oxaliplatin resistance in colorectal cancer cells is mediated via activation of ABCG2 to alleviate ER stress induced apoptosis
- (2018) Hsi-Hsien Hsu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
- (2018) Jian Li et al. Journal of Hematology & Oncology
- Next generation of immune checkpoint therapy in cancer: new developments and challenges
- (2018) Julian A. Marin-Acevedo et al. Journal of Hematology & Oncology
- Adjuvant vemurafenib in resected, BRAF V600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
- (2018) Michele Maio et al. LANCET ONCOLOGY
- The Dual PI3K/mToR Inhibitor Omipalisib/GSK2126458 Inhibits Clonogenic Growth in Oncogenically-transformed Cells from Neurocutaneous Melanocytosis
- (2018) DIPANJAN BASU et al. Cancer Genomics & Proteomics
- Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors
- (2018) Asha Nayak-Kapoor et al. Journal for ImmunoTherapy of Cancer
- An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
- (2018) Hanyong Sun et al. Nature Communications
- A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)–only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer
- (2017) Rebecca Kristeleit et al. GYNECOLOGIC ONCOLOGY
- Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
- (2017) Matthew A. Coelho et al. IMMUNITY
- Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
- (2017) Nicole Glodde et al. IMMUNITY
- CAR T-cell therapy of solid tumors
- (2017) Carmen S M Yong et al. IMMUNOLOGY AND CELL BIOLOGY
- Tumor-associated macrophages: from basic research to clinical application
- (2017) Li Yang et al. Journal of Hematology & Oncology
- Wnt/beta-catenin pathway: modulating anticancer immune response
- (2017) Sachin Gopalkrishna Pai et al. Journal of Hematology & Oncology
- The role of stromal cancer-associated fibroblasts in pancreatic cancer
- (2017) Dagny von Ahrens et al. Journal of Hematology & Oncology
- TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs
- (2017) Haejung Won et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Dabrafenib plus trametinib in patients with previously untreated BRAF V600E -mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial
- (2017) David Planchard et al. LANCET ONCOLOGY
- The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment
- (2017) Nakho Chang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers
- (2017) Guido J.R. Zaman et al. MOLECULAR CANCER THERAPEUTICS
- The immune contexture in cancer prognosis and treatment
- (2017) Wolf H. Fridman et al. Nature Reviews Clinical Oncology
- Adjuvant Dabrafenib plus Trametinib in Stage III BRAF-Mutated Melanoma
- (2017) Georgina V. Long et al. NEW ENGLAND JOURNAL OF MEDICINE
- Induction of PD-L1 expression by epidermal growth factor receptor–mediated signaling in esophageal squamous cell carcinoma
- (2017) Wencheng Zhang et al. OncoTargets and Therapy
- Indoximod Combo Triggers Responses in Melanoma
- (2017) Cancer Discovery
- Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance
- (2017) Marc Hennequart et al. Cancer Immunology Research
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- (2017) Paramahamsa Maturu et al. NEOPLASIA
- STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment
- (2016) S. Koyama et al. CANCER RESEARCH
- The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity
- (2016) Toshiro Moroishi et al. CELL
- Biomarker and Tumor Responses of Oral Cavity Squamous Cell Carcinoma to Trametinib: A Phase II Neoadjuvant Window-of-Opportunity Clinical Trial
- (2016) Ravindra Uppaluri et al. CLINICAL CANCER RESEARCH
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- (2016) Xueyan Ren et al. IMMUNOLOGIC RESEARCH
- Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment
- (2016) Yan Cui et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer
- (2016) Nan Zhang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
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- (2016) Sonia Moretti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2016) Jared J. Barrott et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial
- (2016) Paolo A Ascierto et al. LANCET ONCOLOGY
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- (2016) Xiaoran Zhang et al. NEURO-ONCOLOGY
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- (2016) Verena Leidgens et al. Oncotarget
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- Comparison of dabrafenib and trametinib combination therapy with vemurafenib monotherapy on health-related quality of life in patients with unresectable or metastatic cutaneous BRAF Val600-mutation-positive melanoma (COMBI-v): results of a phase 3, open-label, randomised trial
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- Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
- (2015) Stefani Spranger et al. NATURE
- Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer
- (2015) Vincenzo Bronte et al. NATURE MEDICINE
- Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib
- (2015) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- Cancer and the gut microbiota: An unexpected link
- (2015) Laurence Zitvogel et al. Science Translational Medicine
- Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
- (2015) G. Wang et al. Cancer Discovery
- Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy
- (2015) A. Holtzhausen et al. Cancer Immunology Research
- Tumor-intrinsic oncogene pathways mediating immune avoidance
- (2015) Stefani Spranger et al. OncoImmunology
- A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors
- (2015) Hatem H. Soliman et al. Oncotarget
- Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
- (2014) K. Azuma et al. ANNALS OF ONCOLOGY
- Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor
- (2014) H Nishio et al. BRITISH JOURNAL OF CANCER
- The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype
- (2014) Li Zhang et al. CANCER BIOLOGY & THERAPY
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- (2014) Chunxiao Xu et al. CANCER CELL
- Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer
- (2014) George C. Prendergast et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600-mutated melanoma: a phase 1b study
- (2014) Antoni Ribas et al. LANCET ONCOLOGY
- Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression
- (2014) A. J. Garcia et al. MOLECULAR AND CELLULAR BIOLOGY
- Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
- (2014) David Quigley et al. MOLECULAR CANCER RESEARCH
- Combined Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma
- (2014) James Larkin et al. NEW ENGLAND JOURNAL OF MEDICINE
- Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
- (2014) Alberto Toso et al. Cell Reports
- PD-L1 Expression in Triple-Negative Breast Cancer
- (2014) E. A. Mittendorf et al. Cancer Immunology Research
- Inhibition of both BRAF and MEK in BRAFV600E mutant melanoma restores compromised dendritic cell (DC) function while having differential direct effects on DC properties
- (2013) Patrick A. Ott et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal Network
- (2013) G. Guo et al. CANCER RESEARCH
- p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
- (2013) Alexandre Iannello et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The complexity of NF-κB signaling in inflammation and cancer
- (2013) Bastian Hoesel et al. Molecular Cancer
- Innate and adaptive immune cells in the tumor microenvironment
- (2013) Thomas F Gajewski et al. NATURE IMMUNOLOGY
- Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?
- (2013) L. M. Coussens et al. SCIENCE
- Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells
- (2013) S. Spranger et al. Science Translational Medicine
- Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
- (2013) E. A. Akbay et al. Cancer Discovery
- Impact of MAPK Pathway Activation in BRAFV600 Melanoma on T Cell and Dendritic Cell Function
- (2013) Patrick A. Ott et al. Frontiers in Immunology
- Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis
- (2012) S. Ihara et al. CANCER RESEARCH
- NF- B Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells
- (2012) R. Muthuswamy et al. CANCER RESEARCH
- Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma
- (2012) J. S. Khalili et al. CLINICAL CANCER RESEARCH
- CD200R signaling in tumor tolerance and inflammation: A tricky balance
- (2012) Tomasz P Rygiel et al. CURRENT OPINION IN IMMUNOLOGY
- Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer
- (2012) Albert S. Baldwin IMMUNOLOGICAL REVIEWS
- The Receptor for Advanced Glycation End Products Promotes Pancreatic Carcinogenesis and Accumulation of Myeloid-Derived Suppressor Cells
- (2012) P. J. Vernon et al. JOURNAL OF IMMUNOLOGY
- Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic Immune Responses against Breast Cancer Growth Mediated by NK Cells and CD4+ T Cells
- (2012) M. Tkach et al. JOURNAL OF IMMUNOLOGY
- Immune Suppression and Resistance Mediated by Constitutive Activation of Wnt/ -Catenin Signaling in Human Melanoma Cells
- (2012) T. Yaguchi et al. JOURNAL OF IMMUNOLOGY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- BRAF inhibition improves tumor recognition by the immune system
- (2012) Marco Donia et al. OncoImmunology
- Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
- (2011) Michael C. Schmid et al. CANCER CELL
- Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells
- (2011) Mercedes B. Fuertes et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CD200-CD200R signaling suppresses anti-tumor responses independently of CD200 expression on the tumor
- (2011) T P Rygiel et al. ONCOGENE
- Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway
- (2010) David Gilot et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Prognostic significance and mechanism of Treg infiltration in human brain tumors
- (2010) Joannes F.M. Jacobs et al. JOURNAL OF NEUROIMMUNOLOGY
- Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway
- (2010) J. Wei et al. MOLECULAR CANCER THERAPEUTICS
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chemokine Expression in Melanoma Metastases Associated with CD8+ T-Cell Recruitment
- (2009) H. Harlin et al. CANCER RESEARCH
- TLR4 Signaling Induces B7-H1 Expression Through MAPK Pathways in Bladder Cancer Cells
- (2008) Yigang Qian et al. CANCER INVESTIGATION
- Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
- (2008) Jessica B. Katz et al. IMMUNOLOGICAL REVIEWS
- Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation
- (2008) Qiaoling Sun et al. MOLECULAR IMMUNOLOGY
- Activation of Akt as a Mechanism for Tumor Immune Evasion
- (2008) Kyung Hee Noh et al. MOLECULAR THERAPY
- PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
- (2008) C A Crane et al. ONCOGENE
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