Hypoxia controls the glycome signature and galectin-8 – ligand axis to promote pro-tumorigenic properties of metastatic melanoma.

Melanoma‐associated glycosyltransferase GCNT2 as an emerging biomarker and therapeutic target

(2021) M. Perez et al.   BRITISH JOURNAL OF DERMATOLOGY

Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

(2021) Riyao Yang et al.   Nature Communications

Small RNAs are modified with N-glycans and displayed on the surface of living cells

(2021) Ryan A. Flynn et al.   CELL

Delineation of hypoxia-induced proteome shifts in osteosarcoma cells with different metastatic propensities

(2020) Zifeng Song et al.   Scientific Reports

The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice

(2020) Hadas Shatz-Azoulay et al.   Scientific Reports

Inactivating p53 is essential for nerve growth factor receptor to promote melanoma-initiating cell-stemmed tumorigenesis

(2020) Leiwei Jiang et al.   Cell Death & Disease

Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways

(2020) Asmi Chakraborty et al.   JOURNAL OF AUTOIMMUNITY

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth

(2019) Fátima Ferragut et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies

(2019) Evelyn Pardo et al.   MOLECULAR NEUROBIOLOGY

Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma

(2019) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

I-branched carbohydrates as emerging effectors of malignant progression

(2019) Charles J. Dimitroff   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor neoantigens: from basic research to clinical applications

(2019) Tao Jiang et al.   Journal of Hematology & Oncology

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2019) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Unconventional secretion of annexins and galectins

(2018) Stephanie J. Popa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ROLE OF GLYCOSYLATION IN HYPOXIA-DRIVEN CELL MIGRATION AND INVASION

(2018) Cecilia Arriagada et al.   Cell Adhesion & Migration

Loss of GCNT2/I-branched glycans enhances melanoma growth and survival

(2018) Jenna Geddes Sweeney et al.   Nature Communications

Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse

(2018) Dorian Obino et al.   Cell Reports

Galectin-Glycan Interactions as Regulators of B Cell Immunity

(2018) Nicholas Giovannone et al.   Frontiers in Immunology

ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage

(2017) Asmi Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarkers for Response of Melanoma Patients to Immune Checkpoint Inhibitors: A Systematic Review

(2017) Charissa A. C. Jessurun et al.   Frontiers in Oncology

Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis

(2017) Evelyn Pardo et al.   PLoS One

Galectins and Immune Responses—Just How Do They Do Those Things They Do?

(2016) Sandra Thiemann et al.   Annual Review of Immunology

Engineering galectin–glycan interactions for immunotherapy and immunomodulation

(2016) Shaheen A Farhadi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Protein Glycosylation in Cancer

(2015) Sean R. Stowell et al.   Annual Review of Pathology-Mechanisms of Disease

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

(2015) James F Sampson et al.   IMMUNOLOGY AND CELL BIOLOGY

Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential

(2015) Erika M. Yazawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Galectin-8: A matricellular lectin with key roles in angiogenesis

(2014) M. F. Troncoso et al.   GLYCOBIOLOGY

Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells

(2014) Chuan Wu et al.   IMMUNITY

Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains

(2014) Christina E. Faller et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Galectin-3 Contributes to Melanoma Growth and Metastasis via Regulation of NFAT1 and Autotaxin

(2012) R. R. Braeuer et al.   CANCER RESEARCH

Galectins and their ligands: negative regulators of anti-tumor immunity

(2012) Filiberto Cedeno-Laurent et al.   GLYCOCONJUGATE JOURNAL

The sweet and bitter sides of galectins in melanoma progression

(2012) Russell R. Braeuer et al.   Pigment Cell & Melanoma Research

Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor Immunity

(2011) Filiberto Cedeno-Laurent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1

(2011) Yair Herishanu et al.   LEUKEMIA & LYMPHOMA

Modulation of endothelial cell migration and angiogenesis: a novel function for the “tandem-repeat” lectin galectin-8

(2010) Víctor M. Cárdenas Delgado et al.   FASEB JOURNAL

Cancer stem cells: problems for therapy?

(2010) Malcolm R Alison et al.   JOURNAL OF PATHOLOGY

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

(2010) Alexander D. Boiko et al.   NATURE

Folding of glycoproteins: toward understanding the biophysics of the glycosylation code

(2009) Dalit Shental-Bechor et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions

(2009) Leah N. Cueni et al.   EXPERIMENTAL CELL RESEARCH

Carcinoembryonic Antigen and CD44 Variant Isoforms Cooperate to Mediate Colon Carcinoma Cell Adhesion to E- and L-selectin in Shear Flow

(2008) Susan N. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY