Glycoengineering of chimeric antigen receptor (CAR) T-cells to enforce E-selectin binding

The First Step in Adoptive Cell Immunotherapeutics: Assuring Cell Delivery via Glycoengineering

(2019) Robert Sackstein   Frontiers in Immunology

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

(2019) Mark Esposito et al.   NATURE CELL BIOLOGY

Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells

(2018) Nandini Mondal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligation of the CD44 Glycoform HCELL on Culture-Expanded Human Monocyte-Derived Dendritic Cells Programs Transendothelial Migration

(2018) Paula A. Videira et al.   JOURNAL OF IMMUNOLOGY

mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell–derived hematopoietic progenitors

(2017) Jungmin Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology

(2017) Mariana Silva et al.   JOURNAL OF IMMUNOLOGY

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

(2017) Robert Sackstein et al.   LABORATORY INVESTIGATION

Production of a germline-humanized cetuximab scFv and evaluation of its activity in recognizing EGFR- overexpressing cancer cells

(2017) Arsham Banisadr et al.   Human Vaccines & Immunotherapeutics

Glycosphingolipids on Human Myeloid Cells Stabilize E-Selectin–Dependent Rolling in the Multistep Leukocyte Adhesion CascadeSignificance

(2016) Nandini Mondal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone

(2016) Kathleen C. Day et al.   CANCER RESEARCH

Redirecting T-Cell Specificity to EGFR Using mRNA to Self-limit Expression of Chimeric Antigen Receptor

(2016) Hillary G. Caruso et al.   JOURNAL OF IMMUNOTHERAPY

Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells

(2016) Brad Dykstra et al.   STEM CELLS

Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma

(2015) Laura A. Johnson et al.   Science Translational Medicine

HCELL Expression on Murine MSC Licenses Pancreatotropism and Confers Durable Reversal of Autoimmune Diabetes in NOD Mice

(2015) Reza Abdi et al.   STEM CELLS

ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes

(2014) N. Mondal et al.   BLOOD

Targeting the EGFR signaling pathway in cancer therapy

(2012) Parthasarathy Seshacharyulu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Enforced hematopoietic cell E- and L-selectin ligand (HCELL) expression primes transendothelial migration of human mesenchymal stem cells

(2011) S. P. Thankamony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration

(2009) Robert Sackstein   IMMUNOLOGICAL REVIEWS

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE