The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors

The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies

(2022) Hamidreza Zalpoor et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Ephrin (Eph) receptor and downstream signaling pathways: a promising potential targeted therapy for COVID‑19 and associated cancers and diseases

(2022) Hamidreza Zalpoor et al.   Human Cell

Increased neuropilin-1 expression by COVID-19: a possible cause of long-term neurological complications and progression of primary brain tumors

(2022) Hamidreza Zalpoor et al.   Human Cell

The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors

(2022) Samaneh Mostafavi et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Hypoxia‐inducible factor 1 alpha (HIF‐1α) stimulated and P2X7 receptor activated by COVID-19, as a potential therapeutic target and risk factor for epilepsy

(2022) Hamidreza Zalpoor et al.   Human Cell

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Immune checkpoint inhibition in COVID-19: risks and benefits

(2021) Parmida Sadat Pezeshki et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Anti-tumor activity of NLG207 (formerly CRLX101) in combination with enzalutamide in preclinical prostate cancer models

(2021) Keith T Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective

(2021) Abdellah Akil et al.   Frontiers in Cell and Developmental Biology

TAK1 signaling is a potential therapeutic target for pathological angiogenesis

(2021) Linxin Zhu et al.   ANGIOGENESIS

Role of Notch, IL‑1 and leptin expression in colorectal cancer

(2021) Nilufer Erkasap et al.   Experimental and Therapeutic Medicine

Angiogenesis as a hallmark of solid tumors - clinical perspectives

(2021) Jamal Majidpoor et al.   CELLULAR ONCOLOGY

Programmed death ligand‐1 regulates angiogenesis and metastasis by participating in the c‐JUN/VEGFR2 signaling axis in ovarian cancer

(2021) Yufei Yang et al.   Cancer Communications

Recent advances in regenerative medicine strategies for cancer treatment

(2021) Vahid Mansouri et al.   BIOMEDICINE & PHARMACOTHERAPY

Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis

(2021) Valeria Manuelli et al.   FEBS Journal

Different T cell related immunological profiles in COVID-19 patients compared to healthy controls

(2021) Armin Mahmoud Salehi Khesht et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Adverse events associated with immune checkpoint inhibitors in patients with breast cancer: A systematic review and meta-analysis

(2021) Maryam Balibegloo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Silencing STAT3 enhances sensitivity of cancer cells to doxorubicin and inhibits tumor progression

(2021) Navneet Joshi et al.   LIFE SCIENCES

Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with hydroalcoholic extract of Securigera Securidaca seeds, and Glibenclamide

(2021) Mohammad Babaei et al.   Reproductive Biology and Endocrinology

The impact of mitochondria on cancer treatment resistance

(2021) Michelle van der Merwe et al.   CELLULAR ONCOLOGY

Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages

(2021) Indumathi Manoharan et al.   Frontiers in Immunology

Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention

(2021) Nazanin Momeni Roudsari et al.   Pharmaceutics

Unlocking the Wnt pathway: Therapeutic potential of selective targeting FZD7 in cancer

(2021) Yonika Larasati et al.   DRUG DISCOVERY TODAY

Targeting cancer metabolism in the era of precision oncology

(2021) Zachary E. Stine et al.   NATURE REVIEWS DRUG DISCOVERY

Lactate Is a Metabolic Mediator That Shapes Immune Cell Fate and Function

(2021) Heather L. Caslin et al.   Frontiers in Physiology

Lactate in the tumour microenvironment: From immune modulation to therapy

(2021) Zi-Hao Wang et al.   EBioMedicine

Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

(2021) Camille L. Duran et al.   Cancers

Tumor Microenvironment

(2020) Borros Arneth   Medicina-Lithuania

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

(2020) Ana Rakita et al.   Scientific Reports

Investigation of the Possible Role of Tie2 Pathway and TEK Gene in Asthma and Allergic Conjunctivitis

(2020) Zsófia Gál et al.   Frontiers in Genetics

Pro-tumorigenic functions of macrophages at the primary, invasive and metastatic tumor site

(2020) Elaheh Nasrollahzadeh et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Metabolic alterations in the tumor microenvironment and their role in oncogenesis

(2020) Lihie Eisenberg et al.   CANCER LETTERS

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

(2020) Luo-Qin Fu et al.   CELLULAR IMMUNOLOGY

Immuno-Metabolism and Microenvironment in Cancer: Key Players for Immunotherapy

(2020) Gaia Giannone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study

(2020) Michael S Lee et al.   LANCET ONCOLOGY

The critical role of the interplays of EphrinB2/EphB4 and VEGF in the induction of angiogenesis

(2020) Enming Du et al.   MOLECULAR BIOLOGY REPORTS

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF

(2020) H. H. Pulkkinen et al.   ANGIOGENESIS

Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

(2020) Won Suk Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Immune escape: A critical hallmark in solid tumors

(2020) Keywan Mortezaee   LIFE SCIENCES

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

(2020) Kristen Fousek et al.   PHARMACOLOGY & THERAPEUTICS

Tie2‐expressing monocytes as a novel angiogenesis‐related cellular biomarker for non‐small cell lung cancer

(2020) Rui Xue et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-associated neutrophils as new players in immunosuppressive process of the tumor microenvironment in breast cancer

(2020) Farnaz Hajizadeh et al.   LIFE SCIENCES

Angiogenesis-Related Functions of Wnt Signaling in Colorectal Carcinogenesis

(2020) Aldona Kasprzak   Cancers

Characteristics of the Tumor Microenvironment That Influence Immune Cell Functions: Hypoxia, Oxidative Stress, Metabolic Alterations

(2020) Ryan C. Augustin et al.   Cancers

Innate lymphoid cells as regulators of the tumor microenvironment

(2019) Sonia Tugues et al.   SEMINARS IN IMMUNOLOGY

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

(2019) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The adjuvant treatment of kidney cancer: a multidisciplinary outlook

(2019) Camillo Porta et al.   Nature Reviews Nephrology

The Role of Tumor-Associated Neutrophils in Colorectal Cancer

(2019) Rei Mizuno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Wnt signaling pathway: a potential therapeutic target against cancer

(2019) Noyel Ghosh et al.   Annals of the New York Academy of Sciences

A critical review of the role of M2PYK in the Warburg effect

(2019) Robert A. Harris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds

(2019) Youhan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment

(2019) Deepshikha Mishra et al.   Cancers

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression

(2019) Antonino Bruno et al.   Frontiers in Immunology

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

(2019) Selena Vigano et al.   Frontiers in Immunology

Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors

(2019) Marijo Bilusic et al.   Journal for ImmunoTherapy of Cancer

28PGLPG 1790, a new selective EPHA2 inhibitor, is active in colorectal cancer cell lines belonging to the CMS4/mesenchymal-like subtype

(2019) P P Vitiello et al.   ANNALS OF ONCOLOGY

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oncometabolites in renal cancer

(2019) Cissy Yong et al.   Nature Reviews Nephrology

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

(2019) Maria Teresa Masucci et al.   Frontiers in Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling

(2019) Li Wan et al.   BMC Complementary and Alternative Medicine

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

(2019) Shamir Cassim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights

(2019) Sonal Patel et al.   Frontiers in Immunology

TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association

(2018) Justin Zonneville et al.   BMC CANCER

LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response

(2018) Ji Hee Ha et al.   CANCER RESEARCH

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

(2018) Valeria Quaranta et al.   CANCER RESEARCH

Immune cells regulate VEGF signalling via release of VEGF and antagonistic soluble VEGF receptor-1

(2018) T. Hoeres et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Angiogenin and the MMP9–TIMP2 axis are up-regulated in proangiogenic, decidual NK-like cells from patients with colorectal cancer

(2018) Antonino Bruno et al.   FASEB JOURNAL

Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC

(2018) Mark A. Socinski et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Prokineticins: Neuromodulators and Mediators of Inflammation and Myeloid Cell-Dependent Angiogenesis

(2018) Lucia Negri et al.   PHYSIOLOGICAL REVIEWS

Angiogenic Factors produced by Hypoxic Cells are a leading driver of Anastomoses in Sprouting Angiogenesis–a computational study

(2018) Maurício Moreira-Soares et al.   Scientific Reports

Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy

(2018) Adriana Albini et al.   Frontiers in Immunology

Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

(2018) Yiliang Li et al.   Frontiers in Immunology

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Cross talk between natural killer cells and mast cells in tumor angiogenesis

(2018) Domenico Ribatti et al.   INFLAMMATION RESEARCH

A first-in-human phase 1 dose-escalation trial of the oral HIF-2a inhibitor PT2977 in patients with advanced solid tumors.

(2018) Kyriakos P. Papadopoulos et al.   JOURNAL OF CLINICAL ONCOLOGY

First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

(2018) Leora Horn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-22 promotes tumor angiogenesis

(2018) Nicholas J. Protopsaltis et al.   ANGIOGENESIS

ADSCs and adipocytes are the main producers in the autotaxin–lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro

(2018) Rafael Schmid et al.   BMC CANCER

Extracellular nucleotides and nucleosides as signalling molecules

(2018) Anna Lisa Giuliani et al.   IMMUNOLOGY LETTERS

The role of the hypoxia-Nrp-1 axis in the activation of M2-like tumor-associated macrophages in the tumor microenvironment of cervical cancer

(2018) Xiao-Jing Chen et al.   MOLECULAR CARCINOGENESIS

Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

(2018) Silke Reinartz et al.   Molecular Oncology

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myeloid-derived suppressor cells: Important contributors to tumor progression and metastasis

(2017) Elham Safarzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IL-17–Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin

(2017) James J. Campbell et al.   JOURNAL OF IMMUNOLOGY

The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies

(2017) Changbin Zhu et al.   NEURO-ONCOLOGY

The role and significance of VEGFR2+ regulatory T cells in tumor immunity

(2017) Panrong Zhu et al.   OncoTargets and Therapy

Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

(2017) Ewelina Krzywinska et al.   Nature Communications

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

(2017) Medya Mara Shikhagaie et al.   Cell Reports

Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma

(2017) Karim Chamie et al.   JAMA Oncology

EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease

(2016) Du Yang et al.   ANGIOGENESIS

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress

(2016) De Huang et al.   CELL RESEARCH

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)

(2016) MASARU KATOH   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Discovery of 3-(5′-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation

(2016) Wei Yan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma

(2016) Jayashree Kalpathy-Cramer et al.   JOURNAL OF NEURO-ONCOLOGY

Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics

(2016) Gagan Deep et al.   MOLECULAR CARCINOGENESIS

Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

(2016) Christoph S N Klose et al.   NATURE IMMUNOLOGY

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

(2016) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-associated fibroblasts in hepatocellular carcinoma

(2016) Norio Kubo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts

(2016) Alessandro Arcucci et al.   Biomed Research International

Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

(2015) Thomas Condamine et al.   Annual Review of Medicine

Dual targeting of Angiopoetin-2 and VEGF potentiates effective vascular normalisation without inducing empty basement membrane sleeves in xenograft tumours

(2015) O Coutelle et al.   BRITISH JOURNAL OF CANCER

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth

(2015) X. Ma et al.   CANCER RESEARCH

The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer

(2015) N. Antonio et al.   EMBO JOURNAL

Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality

(2015) A. McIntyre et al.   EMBO Molecular Medicine

New insights into the autotaxin/LPA axis in cancer development and metastasis

(2015) Raphaël Leblanc et al.   EXPERIMENTAL CELL RESEARCH

VEGFR-1 activation-induced MMP-9-dependent invasion in hepatocellular carcinoma

(2015) Tao Li et al.   Future Oncology

A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041)

(2015) Joanne W. Chiu et al.   INVESTIGATIONAL NEW DRUGS

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

The interaction of anticancer therapies with tumor-associated macrophages

(2015) Alberto Mantovani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

(2015) De-Kuan Chang et al.   Molecular Cancer

NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures

(2015) Paolo Carrega et al.   Nature Communications

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

(2015) Helena Serra et al.   Nature Communications

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

(2015) Claudia Sorrentino et al.   Oncotarget

M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression

(2015) Jonghanne Park et al.   Cell Reports

IL17A-Mediated Endothelial Breach Promotes Metastasis Formation

(2015) P. Kulig et al.   Cancer Immunology Research

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

(2015) Sylvian Bron et al.   OncoImmunology

The Emerging Regulation of VEGFR-2 in Triple-Negative Breast Cancer

(2015) Xiaoxia Zhu et al.   Frontiers in Endocrinology

Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes

(2015) Konrad Gabrusiewicz et al.   Oncotarget

Blockade of A2b Adenosine Receptor Reduces Tumor Growth and Immune Suppression Mediated by Myeloid-Derived Suppressor Cells in a Mouse Model of Melanoma

(2015) Raffaella Iannone et al.   NEOPLASIA

The Proangiogenic Phenotype of Natural Killer Cells in Patients with Non-Small Cell Lung Cancer

(2015) Antonino Bruno et al.   NEOPLASIA

Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy

(2014) Rajesh N. Gacche et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Oncometabolites-driven tumorigenesis: From genetics to targeted therapy

(2014) Aurélie Morin et al.   INTERNATIONAL JOURNAL OF CANCER

Neuropilin Regulation of Angiogenesis, Arteriogenesis, and Vascular Permeability

(2014) Alice Plein et al.   MICROCIRCULATION

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2/PGE2 Pathway in the Cancer Cells

(2014) Qingli Li et al.   Cancer Research and Treatment

Trial watch: IDO inhibitors in cancer therapy

(2014) Erika Vacchelli et al.   OncoImmunology

The Impact of the Immune System on Tumor: Angiogenesis and Vascular Remodeling

(2014) Christian Stockmann et al.   Frontiers in Oncology

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

(2013) Nadine Jetten et al.   ANGIOGENESIS

Randomized phase 2 study of pegylated SN-38 (EZN-2208) or irinotecan plus cetuximab in patients with advanced colorectal cancer

(2013) Christopher R. Garrett et al.   CANCER

Myeloid-derived suppressor cells in glioma

(2013) Masoud Mirghorbani et al.   Expert Review of Neurotherapeutics

Tumor associated macrophages and neutrophils in cancer

(2013) Maria Rosaria Galdiero et al.   IMMUNOBIOLOGY

Mast cells and macrophages exert beneficial and detrimental effects on tumor progression and angiogenesis

(2013) Domenico Ribatti   IMMUNOLOGY LETTERS

First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

(2013) Glen J. Weiss et al.   INVESTIGATIONAL NEW DRUGS

Angiogenesis and mast cell density in invasive pulmonary adenocarcinoma

(2013) Ehsan Ullah et al.   Journal of Cancer Research and Therapeutics

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

(2013) Alicia S Chung et al.   NATURE MEDICINE

Emergence of spatial structure in the tumor microenvironment due to the Warburg effect

(2013) C. Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Frequency of Tumor-infiltrating Tie–2-expressing Monocytes in Renal Cell Carcinoma: Its Relationship to Angiogenesis and Progression

(2013) Jindong Ji et al.   UROLOGY

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

(2012) Jaclyn Sceneay et al.   CANCER RESEARCH

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

Diversity of IL-17-producing T lymphocytes

(2012) Jiyeon S. Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pazopanib for the Treatment of Metastatic Renal Cell Carcinoma

(2012) Amy M. Pick et al.   CLINICAL THERAPEUTICS

Bevacizumab: overview of the literature

(2012) Maria Ignez Braghiroli et al.   Expert Review of Anticancer Therapy

TIE2-expressing monocytes: A novel cellular biomarker for hepatocellular carcinoma?

(2012) Michele De Palma et al.   HEPATOLOGY

Cancer prevention by targeting angiogenesis

(2012) Adriana Albini et al.   Nature Reviews Clinical Oncology

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Robustness in angiogenesis: Notch and BMP shaping waves

(2012) Karen Beets et al.   TRENDS IN GENETICS

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The role of pericytes in angiogenesis

(2011) Domenico Ribatti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma

(2011) Masayasu Jo et al.   JOURNAL OF GASTROENTEROLOGY

Optimisation of breast cancer management in low-resource and middle-resource countries: executive summary of the Breast Health Global Initiative consensus, 2010

(2011) Benjamin O Anderson et al.   LANCET ONCOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

(2010) Dusan Djokovic et al.   BMC CANCER

Knockout of HIF-1  in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

(2010) C. Werno et al.   CARCINOGENESIS

Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor by promoting angiogenesis

(2010) Daiko Wakita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phase II Study of Cediranib, an Oral Pan–Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Recurrent Glioblastoma

(2010) Tracy T. Batchelor et al.   JOURNAL OF CLINICAL ONCOLOGY

Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasis

(2010) Xian-Zong Ye et al.   Journal of Genetics and Genomics

IL-12 initiates tumor rejection via lymphoid tissue–inducer cells bearing the natural cytotoxicity receptor NKp46

(2010) Maya Eisenring et al.   NATURE IMMUNOLOGY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation

(2010) Michael C. Schmid et al.   Journal of Oncology

Regulation of tumor angiogenesis by the local environment

(2009) Kelly Hall   Frontiers in Bioscience-Landmark

Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients

(2009) Jing-Ping Zhang et al.   JOURNAL OF HEPATOLOGY

Protumor vs Antitumor Functions of IL-17

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Glycolytic metabolism and tumour response to fractionated irradiation

(2009) Ulrike G.A. Sattler et al.   RADIOTHERAPY AND ONCOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Sustained lower rates of breast cancer in the United States

(2008) Kathleen A. Cronin et al.   BREAST CANCER RESEARCH AND TREATMENT

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Wnt Signaling in Angiogenesis

(2008) Nancy Parmalee et al.   CURRENT DRUG TARGETS

Axitinib for renal cell carcinoma

(2008) Guru Sonpavde et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

(2008) Willscott E. Naugler et al.   TRENDS IN MOLECULAR MEDICINE

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

(2008) Kristian Pietras et al.   PLOS MEDICINE

The Molecular Basis of VEGFR-1 Signal Transduction Pathways in Primary Human Monocytes

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