Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells

(2018) Sonja Lieber et al.   OncoImmunology

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment

(2017) Thomas Worzfeld et al.   MOLECULAR & CELLULAR PROTEOMICS

The Unique Molecular and Cellular Microenvironment of Ovarian Cancer

(2017) Thomas Worzfeld et al.   Frontiers in Oncology

Characterization of ovarian cancer cell lines as in vivo models for preclinical studies

(2016) Lidia Hernandez et al.   GYNECOLOGIC ONCOLOGY

Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism

(2016) Eun Jin Seo et al.   STEM CELLS

Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gαi2, Src, and HIF1α signaling nexus

(2016) Ji Hee Ha et al.   Oncotarget

Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma

(2015) Rebecca J. Burkhalter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidic acid signaling in ovarian cancer

(2015) Anna Jesionowska et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Whole–genome characterization of chemoresistant ovarian cancer

(2015) Ann-Marie Patch et al.   NATURE

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

(2015) Tan A. Ince et al.   Nature Communications

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

(2015) Verena Rohnalter et al.   Oncotarget

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment

(2015) Tim Schumann et al.   Oncotarget

Secretory phospholipase A2 enzymes as pharmacological targets for treatment of disease

(2014) Nhat D. Quach et al.   BIOCHEMICAL PHARMACOLOGY

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays

(2013) Semjon Willier et al.   BIOLOGY OF THE CELL

Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: Correlation of CD163 expression, cytokine levels and early relapse

(2013) Silke Reinartz et al.   INTERNATIONAL JOURNAL OF CANCER

Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patients

(2012) Balázs Győrffy et al.   ENDOCRINE-RELATED CANCER

Autotaxin and LPA receptor signaling in cancer

(2011) Anna J. S. Houben et al.   CANCER AND METASTASIS REVIEWS

Plasmalogens the neglected regulatory and scavenging lipid species

(2011) Stefan Wallner et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

(2011) Andrés Nieto-Posadas et al.   Nature Chemical Biology

Aiming drug discovery at lysophosphatidic acid targets

(2010) Gabor Tigyi   BRITISH JOURNAL OF PHARMACOLOGY

Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells

(2010) Susanne Vidot et al.   CELLULAR SIGNALLING

Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1α from human mesenchymal stem cells

(2010) Eun Su Jeon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

LPA 1 receptors mediate stimulation, whereas LPA 2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites

(2009) Mayumi Komachi et al.   CARCINOGENESIS

Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice

(2009) H. Li et al.   MOLECULAR CANCER THERAPEUTICS

Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells

(2009) Cristoforo G. Gaetano et al.   MOLECULAR CARCINOGENESIS

A new real-time PCR method to overcome significant quantitative inaccuracy due to slight amplification inhibition

(2008) Michele Guescini et al.   BMC BIOINFORMATICS