Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

Adaptor protein ShcD/SHC4 interacts with Tie2 receptor to synergistically promote glioma cell invasion

(2021) Manali Tilak et al.   MOLECULAR CANCER RESEARCH

Breast Cancer Cell Re-Dissemination from Lung Metastases—A Mechanism for Enhancing Metastatic Burden

(2021) Lucia Borriello et al.   Journal of Clinical Medicine

Tumor cell-derived Angiopoietin-2 promotes metastasis in melanoma

(2020) Ashik Ahmed Abdul Pari et al.   CANCER RESEARCH

Ripretinib: First Approval

(2020) Sohita Dhillon   DRUGS

The role of the tumor microenvironment in tumor cell intravasation and dissemination

(2020) Lucia Borriello et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Hematogenous Dissemination of Breast Cancer Cells From Lymph Nodes Is Mediated by Tumor MicroEnvironment of Metastasis Doorways

(2020) Anouchka Coste et al.   Frontiers in Oncology

Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants

(2019) Bryan D. Smith et al.   CANCER CELL

Overexpression of Tie2 is associated with poor prognosis in patients with gastric cancer

(2018) Wei‑Jun Yang et al.   Oncology Letters

TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation

(2017) Mohammad B. Hossain et al.   MOLECULAR AND CELLULAR BIOLOGY

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors

(2017) Allison S. Harney et al.   MOLECULAR CANCER THERAPEUTICS

A permanent window for the murine lung enables high-resolution imaging of cancer metastasis

(2017) David Entenberg et al.   NATURE METHODS

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism

(2017) George S. Karagiannis et al.   Science Translational Medicine

The Multifaceted Role of Perivascular Macrophages in Tumors

(2016) Claire E. Lewis et al.   CANCER CELL

Tie2 Expression on Macrophages Is Required for Blood Vessel Reconstruction and Tumor Relapse after Chemotherapy

(2016) Lin Chen et al.   CANCER RESEARCH

Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth

(2016) Liye Chen et al.   Oncotarget

TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1

(2016) M. B. Hossain et al.   Science Advances

TMEM: a novel breast cancer dissemination marker for the assessment of metastatic risk

(2015) Maja H Oktay et al.   Biomarkers in Medicine

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Hematopoietic Stem Cell–Derived Cancer–Associated Fibroblasts Are Novel Contributors to the Pro-Tumorigenic Microenvironment

(2015) Lindsay T. McDonald et al.   NEOPLASIA

Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes

(2015) Konrad Gabrusiewicz et al.   Oncotarget

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer

(2014) Thomas E. Rohan et al.   JNCI-Journal of the National Cancer Institute

Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis

(2014) Vladimir Riabov et al.   Frontiers in Physiology

Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial

(2012) Axel Grothey et al.   LANCET

Tie2+Bone Marrow Endothelial Cells Regulate Hematopoietic Stem Cell Regeneration Following Radiation Injury

(2012) Phuong L. Doan et al.   STEM CELLS

Targeting the ANG2/TIE2 Axis Inhibits Tumor Growth and Metastasis by Impairing Angiogenesis and Disabling Rebounds of Proangiogenic Myeloid Cells

(2011) Roberta Mazzieri et al.   CANCER CELL

Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis

(2011) E. Fagiani et al.   CANCER RESEARCH

Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth

(2011) H. Huang et al.   CLINICAL CANCER RESEARCH

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

(2010) Young Jun Koh et al.   CANCER CELL

Angiopoietin-4 Promotes Glioblastoma Progression by Enhancing Tumor Cell Viability and Angiogenesis

(2010) M. K. Brunckhorst et al.   CANCER RESEARCH

The role of the Angiopoietins in vascular morphogenesis

(2009) Markus Thomas et al.   ANGIOGENESIS

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth

(2009) Patrick Nasarre et al.   CANCER RESEARCH

Angiopoietin-2 Levels Are Associated with Disease Progression in Metastatic Malignant Melanoma

(2009) I. Helfrich et al.   CLINICAL CANCER RESEARCH

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

(2009) B. D. Robinson et al.   CLINICAL CANCER RESEARCH

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Angiopoietin-2: Development of inhibitors for cancer therapy

(2009) Bo Hu et al.   Current Oncology Reports

Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis

(2008) Christopher S. Milner et al.   MICROVASCULAR RESEARCH

Angiopoietin-2 levels in the hepatic vein as a useful predictor of tumor invasiveness and prognosis in human hepatocellular carcinoma

(2007) Satoshi Kuboki et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY