TAK1 signaling is a potential therapeutic target for pathological angiogenesis

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway

(2020) Kanika Singh et al.   Scientific Reports

C20orf27 Promotes Cell Growth and Proliferation of Colorectal Cancer via the TGFβR-TAK1-NFĸB Pathway

(2020) Jing Gao et al.   Cancers

Activation of AMPK under Hypoxia: Many Roads Leading to Rome

(2020) Franziska Dengler   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling

(2020) Hai-feng Zhang et al.   ACTA PHARMACOLOGICA SINICA

Oxidative Stress Induces a VEGF Autocrine Loop in the Retina: Relevance for Diabetic Retinopathy

(2020) Maria Grazia Rossino et al.   Cells

CRISPR/Cas9-Mediated OC-2 Editing Inhibits the Tumor Growth and Angiogenesis of Ovarian Cancer

(2020) Tongyi Lu et al.   Frontiers in Oncology

Live imaging of angiogenesis during cutaneous wound healing in adult zebrafish

(2019) Chikage Noishiki et al.   ANGIOGENESIS

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

(2019) Hisamichi Naito et al.   DEVELOPMENTAL CELL

Oxidative stress-induced angiogenesis

(2019) Yu-Jing Huang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Tanshinone IIA inhibits lipopolysaccharide‑induced inflammatory responses through the TLR4/TAK1/NF‑κB signaling pathway in vascular smooth muscle cells

(2019) Zhe Meng et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma

(2019) Biswajit Podder et al.   CELL DEATH AND DIFFERENTIATION

TAK1 regulates endothelial cell necroptosis and tumor metastasis

(2019) Lida Yang et al.   CELL DEATH AND DIFFERENTIATION

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

A genome‐wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS ‐mutant melanoma

(2019) Adi Nagler et al.   Pigment Cell & Melanoma Research

Hypoxia and EGF Stimulation Regulate VEGF Expression in Human Glioblastoma Multiforme (GBM) Cells by Differential Regulation of the PI3K/Rho-GTPase and MAPK Pathways

(2019) Samer Nicolas et al.   Cells

Controlled release technology for anti-angiogenesis treatment of posterior eye diseases: Current status and challenges

(2018) Chi Ming Laurence Lau et al.   ADVANCED DRUG DELIVERY REVIEWS

Upregulation of NOX2 and NOX4 Mediated by TGF-β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury

(2018) Zheng Lou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

(2018) Matthew V. Russo et al.   NATURE IMMUNOLOGY

Real-world outcomes in patients with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth factor inhibitors

(2018) Hemal Mehta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis

(2018) Oihana Iriondo et al.   Nature Communications

NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo

(2018) Qizhao Ma et al.   APOPTOSIS

Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides

(2018) Chao Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Post-Translational Modifications of the TAK1-TAB Complex

(2017) Yusuke Hirata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats

(2017) Hua Wang et al.   Molecular Medicine Reports

LYTAK1 attenuates proliferation of retinal pigment epithelial cells through TGF‑β‑mediated epithelial‑mesenchymal transition via the ERK/AKT signaling pathway

(2017) Zhen Chen et al.   Experimental and Therapeutic Medicine

Genome editing abrogates angiogenesis in vivo

(2017) Xionggao Huang et al.   Nature Communications

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes cervical cancer to doxorubicin-induced apoptosis

(2017) Shan Guan et al.   Oncotarget

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis

(2017) Jie Li et al.   Cell Discovery

LYATK1 potently inhibits LPS-mediated pro-inflammatory response

(2016) Feng Xi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-892b Silencing Activates NF- B and Promotes Aggressiveness in Breast Cancer

(2016) L. Jiang et al.   CANCER RESEARCH

NADPH oxidase 2 plays a role in experimental corneal neovascularization

(2016) E. C. Chan et al.   CLINICAL SCIENCE

Hypoxia/ischemia promotes CXCL10 expression in cardiac microvascular endothelial cells by NFkB activation

(2016) Jing-Bo Xia et al.   CYTOKINE

Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy

(2016) Yanhong Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

LYTAK1, a TAK1 inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells

(2016) ZHEN CHEN et al.   Molecular Medicine Reports

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation

(2016) Douglas S Jones et al.   Nature Chemical Biology

TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells

(2016) Zhenyu Wang et al.   Scientific Reports

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Identification of Aminoimidazole and Aminothiazole Derivatives as Src Family Kinase Inhibitors

(2015) Cinzia Maria Francini et al.   ChemMedChem

The roles of CRISPR–Cas systems in adaptive immunity and beyond

(2015) Rodolphe Barrangou   CURRENT OPINION IN IMMUNOLOGY

Chronic Inflammation and Colorectal Cancer: The Role of Vascular Endothelial Growth Factor

(2015) Tao Hu et al.   CURRENT PHARMACEUTICAL DESIGN

TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage

(2015) Dingding Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

(2015) Agnieszka Zimna et al.   Biomed Research International

Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy

(2015) Hyun-Woo Lee et al.   BMB Reports

Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer

(2015) Hui-Ling Huang et al.   Oncotarget

TAK1 control of cell death

(2014) S R Mihaly et al.   CELL DEATH AND DIFFERENTIATION

Genome modification by CRISPR/Cas9

(2014) Yuanwu Ma et al.   FEBS Journal

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

TAK1 regulates hepatic cell survival and carcinogenesis

(2014) Yoon Seok Roh et al.   JOURNAL OF GASTROENTEROLOGY

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

(2014) Li Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3

(2014) Na Zhao et al.   Molecular Cancer

Roles of the Kinase TAK1 in CD40-Mediated Effects on Vascular Oxidative Stress and Neointima Formation after Vascular Injury

(2014) Zifang Song et al.   PLoS One

LYTAK1, a novel TAK1 inhibitor, suppresses KRAS mutant colorectal cancer cell growth in vitro and in vivo

(2014) Jundong Zhou et al.   TUMOR BIOLOGY

LPS-mediated endothelial activation in pulmonary endothelial cells: role of Nox2-dependent IKK-β phosphorylation

(2013) Heather Menden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TAK1 inhibitor 5Z-7-oxozeaenol sensitizes neuroblastoma to chemotherapy

(2013) Yihui Fan et al.   APOPTOSIS

Transforming Growth Factor-β–Activated Kinase 1 Regulates Angiogenesis via AMP-Activated Protein Kinase-α1 and Redox Balance in Endothelial Cells

(2013) Nina Zippel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis

(2013) Bing Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress in angiogenesis and vascular disease

(2013) Y.-W. Kim et al.   BLOOD

GSK-3α Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1–TAB Stabilization and Regulation of Noncanonical NF-κB

(2013) Deepali Bang et al.   Cancer Discovery

Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol

(2012) Jiaquan Wu et al.   ACS Chemical Biology

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration

(2012) S. Morioka et al.   BLOOD

Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

(2012) Katrin Schröder et al.   CIRCULATION RESEARCH

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

(2012) Shalini Pathak et al.   EMBO JOURNAL

Protection from cerebral ischemia by inhibition of TGFβ-activated kinase

(2012) Benjamin J. White et al.   EXPERIMENTAL NEUROLOGY

TAK1, more than just innate immunity

(2012) Liang Dai et al.   IUBMB LIFE

Redox implications of AMPK-mediated signal transduction beyond energetic clues

(2012) S. Cardaci et al.   JOURNAL OF CELL SCIENCE

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

Epithelial transforming growth factor  -activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

(2012) E. Omori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

Ndc80 complex: New evidence for the existence of spindle assembly checkpoint in mammalian oocyte meiosis

(2011) Qing-Yuan Sun   CELL CYCLE

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia

(2011) M Neubert et al.   CELL DEATH AND DIFFERENTIATION

Modulation of Pancreatic Cancer Chemoresistance by Inhibition of TAK1

(2011) Davide Melisi et al.   JNCI-Journal of the National Cancer Institute

AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-β-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway

(2010) Mei-Ying Chang et al.   BIOCHEMICAL PHARMACOLOGY

AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts

(2010) Young-Sun Lee et al.   BONE

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Monogenic IL-1 mediated autoinflammatory and immunodeficiency syndromes: Finding the right balance in response to danger signals

(2010) Cailin Henderson et al.   CLINICAL IMMUNOLOGY

Autoactivation of Transforming Growth Factor β-activated Kinase 1 Is a Sequential Bimolecular Process

(2010) Roland Scholz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF- -Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

(2010) R. Kajino-Sakamoto et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Hypoxia-Induced NF- B

(2010) C. Culver et al.   MOLECULAR AND CELLULAR BIOLOGY

Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

(2010) Kuzhuvelil B. Harikumar et al.   MOLECULAR CANCER RESEARCH

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro

(2010) Y. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation

(2009) Magdalena Koziczak-Holbro et al.   ARTHRITIS AND RHEUMATISM

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

Targeting the hypoxia-inducible factor (HIF) pathway in cancer

(2009) Evon Poon et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

(2009) S. Inokuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pinitol targets nuclear factor-κB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis

(2008) Gautam Sethi et al.   MOLECULAR CANCER THERAPEUTICS