The critical role of the interplays of EphrinB2/EphB4 and VEGF in the induction of angiogenesis

Overexpression of ephrinB2 in stem cells from apical papilla accelerates angiogenesis

(2019) Changyong Yuan et al.   ORAL DISEASES

Essential roles of EphrinB2 in mammalian heart: from development to diseases

(2019) Sheng-an Su et al.   Cell Communication and Signaling

EphrinB2/EphB4 Signaling Regulates DPSCs to Induce Sprouting Angiogenesis of Endothelial Cells

(2019) T. Gong et al.   JOURNAL OF DENTAL RESEARCH

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

(2019) Christina Vrahnas et al.   Nature Communications

EphrinB2/EphB4 signaling regulates non‐sprouting angiogenesis by VEGF

(2018) Elena Groppa et al.   EMBO REPORTS

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

(2018) Christopher M. Adams et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic potential of targeting the Eph/ephrin signaling complex

(2018) Nayanendu Saha et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10 -ablation

(2017) Chao You et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Targeting receptor tyrosine kinase EphB4 in cancer therapy

(2017) Yinnan Chen et al.   SEMINARS IN CANCER BIOLOGY

Discovery and evaluation of triple inhibitors of VEGFR-2, TIE-2 and EphB4 as anti-angiogenic and anti-cancer agents

(2017) Lin Zhang et al.   Oncotarget

EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease

(2016) Du Yang et al.   ANGIOGENESIS

Activation of multiple angiogenic signaling pathways in hemangiopericytoma

(2016) Daniela Pierscianek et al.   Brain Tumor Pathology

EphB4 promotes the proliferation, invasion, and angiogenesis of human colorectal cancer

(2016) JingHuan Lv et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

EphrinB2 Stabilizes Vascularlike Structures Generated by Endothelial Cells and Stem Cells from Apical Papilla

(2016) Changyong Yuan et al.   JOURNAL OF ENDODONTICS

Mechanisms of ephrin–Eph signalling in development, physiology and disease

(2016) Artur Kania et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Study of angiogenic signaling pathways in hemangioblastoma

(2016) Daniela Pierscianek et al.   NEUROPATHOLOGY

Eph Receptors and Ephrins: Therapeutic Opportunities

(2015) Antonio Barquilla et al.   Annual Review of Pharmacology and Toxicology

Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor

(2015) Amogh Sivarapatna et al.   BIOMATERIALS

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

A pilot study of JI-101, an inhibitor of VEGFR-2, PDGFR-β, and EphB4 receptors, in combination with everolimus and as a single agent in an ovarian cancer expansion cohort

(2015) Theresa L. Werner et al.   INVESTIGATIONAL NEW DRUGS

Coculture of Stem Cells from Apical Papilla and Human Umbilical Vein Endothelial Cell Under Hypoxia Increases the Formation of Three-Dimensional Vessel-Like Structuresin Vitro

(2015) Changyong Yuan et al.   TISSUE ENGINEERING PART A

Ephrin B2 and EphB4 selectively mark arterial and venous vessels in cerebral arteriovenous malformation

(2014) Jie Bai et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

The Differential Expression of EphB2 and EphB4 Receptor Kinases in Normal Bladder and in Transitional Cell Carcinoma of the Bladder

(2014) Xiuqing Li et al.   PLoS One

EphB4 as a therapeutic target in mesothelioma

(2013) Ren Liu et al.   BMC CANCER

Therapeutic perspectives of Eph–ephrin system modulation

(2013) Massimiliano Tognolini et al.   DRUG DISCOVERY TODAY

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells

(2013) Chenzi Yang et al.   JOURNAL OF SURGICAL RESEARCH

EphrinB2 Reverse Signaling Protects against Capillary Rarefaction and Fibrosis after Kidney Injury

(2013) Y. Kida et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Spatial regulation of VEGF receptor endocytosis in angiogenesis

(2013) Masanori Nakayama et al.   NATURE CELL BIOLOGY

Therapeutic targeting of EPH receptors and their ligands

(2013) Andrew W. Boyd et al.   NATURE REVIEWS DRUG DISCOVERY

Reduced adult endothelial cell EphB4 function promotes venous remodeling

(2012) Caroline C. Jadlowiec et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4

(2012) Srinivas Duggineni et al.   BIOCHEMICAL PHARMACOLOGY

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth

(2012) M. A. Abengozar et al.   BLOOD

EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner

(2012) Zhan Xiao et al.   CANCER BIOLOGY & THERAPY

Effective Photothermal Chemotherapy Using Doxorubicin-Loaded Gold Nanospheres That Target EphB4 Receptors in Tumors

(2012) J. You et al.   CANCER RESEARCH

Endothelial Tip Cells in Ocular Angiogenesis

(2012) Martin J. Siemerink et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography

(2012) Karine Lafleur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biophysical Characterization and Stabilization of the Recombinant Albumin Fusion Protein sEphB4–HSA

(2012) Shuai Shi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

(2011) Bernard Barlaam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evidence for a dual function of EphB4 as tumor promoter and suppressor regulated by the absence or presence of the ephrin-B2 ligand

(2011) Raphael Rutkowski et al.   INTERNATIONAL JOURNAL OF CANCER

XL647—A Multitargeted Tyrosine Kinase Inhibitor: Results of a Phase II Study in Subjects with Non-small Cell Lung Cancer Who Have Progressed after Responding to Treatment with Either Gefitinib or Erlotinib

(2011) M. Catherine Pietanza et al.   Journal of Thoracic Oncology

Influence of Dll4 via HIF-1α-VEGF Signaling on the Angiogenesis of Choroidal Neovascularization under Hypoxic Conditions

(2011) Xiao Dong et al.   PLoS One

Novel EphB4 Monoclonal Antibodies Modulate Angiogenesis and Inhibit Tumor Growth

(2010) Valery Krasnoperov et al.   AMERICAN JOURNAL OF PATHOLOGY

Ephrin B2/EphB4 pathway in hepatic stellate cells stimulates Erk-dependent VEGF production and sinusoidal endothelial cell recruitment

(2010) Amitava Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis

(2010) Georg Martiny-Baron et al.   ANGIOGENESIS

Endothelial Cell EphrinB2-Dependent Activation of Monocytes in Arteriosclerosis

(2010) Jennifer Braun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

(2010) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ephrins and Eph receptors in stem cells and cancer

(2010) Maria Genander et al.   CURRENT OPINION IN CELL BIOLOGY

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

VEGF and ephrin-B2: a bloody duo

(2010) Stéphane Germain et al.   NATURE MEDICINE

Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy

(2009) Christoph Ehlken et al.   ACTA OPHTHALMOLOGICA

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways

(2009) Tomomi Masumura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Imidazo[1,2-a]pyrazine diaryl ureas: Inhibitors of the receptor tyrosine kinase EphB4

(2009) Scott A. Mitchell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications

(2009) Ji-Liang Li   Frontiers in Bioscience-Landmark

Structure-Based Optimization of Potent and Selective Inhibitors of the Tyrosine Kinase Erythropoietin Producing Human Hepatocellular Carcinoma Receptor B4 (EphB4)

(2009) Karine Lafleur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Soluble ephrin-B2 mediates apoptosis in retinal neovascularization and in endothelial cells

(2009) Michael H. Davies et al.   MICROVASCULAR RESEARCH

Modulation of ephrinB2 leads to increased angiogenesis in ischemic myocardium and endothelial cell proliferation

(2008) Agneta Månsson-Broberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines

(2008) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines

(2008) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade

(2008) J. S. Scehnet et al.   BLOOD

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL