Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

A randomized, phase 2 study investigating TRV130, a biased ligand of the μ-opioid receptor, for the intravenous treatment of acute pain

(2016) Eugene R. Viscusi et al.   PAIN

Effects of repeated morphine on intracranial self-stimulation in male rats in the absence or presence of a noxious pain stimulus.

(2015) Laurence L. Miller et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Site and mechanism of morphine tolerance in the gastrointestinal tract

(2015) H. I. Akbarali et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

(2014) David G. Soergel et al.   PAIN

Effects of the novel, selective and low-efficacy mu opioid receptor ligand NAQ on intracranial self-stimulation in rats

(2014) Ahmad A. Altarifi et al.   PSYCHOPHARMACOLOGY

Biased ligands at G-protein-coupled receptors: promise and progress

(2014) Jonathan D. Violin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Abuse-related effects of µ-opioid analgesics in an assay of intracranial self-stimulation in rats

(2013) Ahmad A. Altarifi et al.   BEHAVIOURAL PHARMACOLOGY

First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

(2013) David G. Soergel et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

(2013) Xiao-Tao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice

(2012) Hercules T. Maguma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Some determinants of morphine effects on intracranial self-stimulation in rats

(2011) Ahmad A. Altarifi et al.   BEHAVIOURAL PHARMACOLOGY

Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology: From a symposium on new concepts in mu-opioid pharmacology

(2011) Kenneth Lamb et al.   DRUG AND ALCOHOL DEPENDENCE

The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics

(2010) Kirsten M. Raehal et al.   NEUROPHARMACOLOGY

Morphine Tolerance in the Mouse Ileum and Colon

(2008) G. R. Ross et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS