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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

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5-HT 2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

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Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist

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Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

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Regulatory Forum Review*: Utility of in Vitro Secondary Pharmacology Data to Assess Risk of Drug-induced Valvular Heart Disease in Humans: Regulatory Considerations

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GPCR Dynamics: Structures in Motion

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Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

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PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

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Structure and function of serotonin G protein-coupled receptors

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PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

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The Dynamic Process of β2-Adrenergic Receptor Activation

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

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Structural Basis for Molecular Recognition at Serotonin Receptors

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Structural Features for Functional Selectivity at Serotonin Receptors

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The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

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Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

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Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

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Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Diversity and modularity of G protein-coupled receptor structures

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Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Conserved Binding Mode of Human β2Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

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The Expanded Biology of Serotonin

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Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment

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Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols

Multiple Switches in G Protein-Coupled Receptor Activation

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Carcinoid heart disease

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Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

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