Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 38, Issue 11, Pages 1016-1037Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2017.08.004
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM079191] Funding Source: Medline
Ask authors/readers for more resources
Pain is both a major clinical and economic problem, affecting more people than diabetes, heart disease, and cancer combined. While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especially those acting on the m-opioid receptor (mOR)and related pathways, have proven to be the most effective, despite some serious side effects including respiration depression, pruritus, dependence, and constipation. It is therefore imperative that both academia and industry develop novel mOR analgesics which retain their opioid analgesic properties but with fewer or no adverse effects. In this review we outline recent progress towards the discovery of safer opioid analgesics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available