NLRP3 inflammasome: The rising star in cardiovascular diseases

Blocking the NLRP3 inflammasome reduces osteogenic calcification and M1 macrophage polarization in a mouse model of calcified aortic valve stenosis

(2022) Jing Lu et al.   ATHEROSCLEROSIS

Interleukin-1 Receptor Antagonism as Adjunct Therapy for Heart Failure Patients with Left Ventricular Assist Devices

(2021) Aaron H. Healy et al.   ASAIO JOURNAL

Pretreatment of Indobufen and Aspirin and their Combinations with Clopidogrel or Ticagrelor Alleviates Inflammasome Mediated Pyroptosis Via Inhibiting NF-κB/NLRP3 Pathway in Ischemic Stroke

(2021) Fengyang Li et al.   Journal of Neuroimmune Pharmacology

Sinapine Thiocyanate Ameliorates Vascular Endothelial Dysfunction in Hypertension by Inhibiting Activation of the NLRP3 Inflammasome

(2021) Yang Liu et al.   Frontiers in Pharmacology

Chlorpromazine and promethazine reduces Brain injury through RIP1-RIP3 regulated activation of NLRP3 inflammasome following ischemic stroke

(2021) Qian Jiang et al.   NEUROLOGICAL RESEARCH

Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction

(2021) Nathan Mewton et al.   CIRCULATION

Comparison of long-term mortality in patients who underwent transcatheter aortic valve replacement with or without anti-atherosclerotic therapy

(2021) Kazuya Sasaki et al.   HEART AND VESSELS

Role of the NLRP3 Inflammasome in Preeclampsia

(2020) Koumei Shirasuna et al.   Frontiers in Endocrinology

ACUTE EFFECTS OF INTERLEUKIN-1 BLOCKADE USING ANAKINRA IN PATIENTS WITH ACUTE PERICARDITIS

(2020) George F. Wohlford et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice

(2020) Pingping Ren et al.   Journal of the American Heart Association

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

(2020) Cheng Zeng et al.   Redox Biology

RHAPSODY: Rationale for and Design of a Pivotal Phase 3 Trial to Assess Efficacy and Safety of Rilonacept, an IL-1α and IL-1β trap, in Patients with Recurrent Pericarditis

(2020) Allan Klein et al.   AMERICAN HEART JOURNAL

Clinical presentation and outcomes of acute pericarditis in a large urban hospital in the United States of America

(2020) Alessandra Vecchié et al.   CHEST

Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells

(2020) Ming Liu et al.   Frontiers in Pharmacology

Colchicine in Patients with Chronic Coronary Disease

(2020) Stefan M. Nidorf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Burden of Recurrent Pericarditis on Health-Related Quality of Life

(2020) Martin LeWinter et al.   AMERICAN JOURNAL OF CARDIOLOGY

Necrotic cell debris induces a NF-κB-driven inflammasome response in vascular smooth muscle cells derived from abdominal aortic aneurysms (AAA-SMC)

(2019) Markus Wortmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study

(2019) Petter Bjornstad et al.   DIABETES CARE

Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases

(2019) Nina Boxberger et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frontline Science: Acyl‐CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages

(2019) Gowri Kalugotla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis

(2019) Luo-Yi Wang et al.   Journal of Translational Medicine

Rev-erbα can regulate the NF-κB/NALP3 pathway to modulate lipopolysaccharide-induced acute lung injury and inflammation

(2019) Dapeng Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

The SGK1 inhibitor EMD638683, prevents Angiotensin II–induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation

(2018) Wenqiang Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis and Atherogenesis

(2018) Marit Westerterp et al.   CIRCULATION

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

(2018) Benoit Pourcet et al.   GASTROENTEROLOGY

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

(2018) Delphine Gomez et al.   NATURE MEDICINE

Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells

(2018) Judit Erdei et al.   Oxidative Medicine and Cellular Longevity

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

(2018) Jianlin Qiao et al.   HAEMATOLOGICA

IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction

(2018) Benjamin W. Van Tassell et al.   Circulation-Heart Failure

Rationale and design of the Virginia Commonwealth University-Anakinra Remodeling Trial-3 (VCU-ART3): A randomized, placebo-controlled, double-blinded, multicenter study

(2018) Benjamin W. Van Tassell et al.   CLINICAL CARDIOLOGY

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

RORγ regulates the NLRP3 inflammasome

(2018) Cyrielle Billon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

(2018) Shuai Wang et al.   Nature Communications

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome

(2017) Raquel Domingo-Fernández et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

(2017) Viola Neudecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

(2017) Merry W. Ma et al.   Oxidative Medicine and Cellular Longevity

Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia

(2017) Neha Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin 22 Promotes Blood Pressure Elevation and Endothelial Dysfunction in Angiotensin II–Treated Mice

(2017) Jing Ye et al.   Journal of the American Heart Association

Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification

(2017) Arkady Rutkovskiy et al.   Journal of the American Heart Association

Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease–Associated Abdominal Aortic AneurysmSignificance

(2016) Daiko Wakita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammasomes as polyvalent cell death platforms

(2016) Nathalia M. de Vasconcelos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents AtherosclerosisNovelty and Significance

(2016) Gantsetseg Tumurkhuu et al.   CIRCULATION RESEARCH

Interleukin 18 promotes myofibroblast activation of valvular interstitial cells

(2016) Jingxin Zhou et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance and Corticosteroid Dependence

(2016) Antonio Brucato et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

(2016) Florian I. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

(2016) Jong-Seok Moon et al.   NATURE MEDICINE

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

NOD-Like Receptors in Infection, Immunity, and Diseases

(2016) Young Keun Kim et al.   YONSEI MEDICAL JOURNAL

NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1

(2015) Jie Qi et al.   Cardiovascular Toxicology

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NLRP3 Deficiency Improves Angiotensin II-Induced Hypertension But Not Fetal Growth Restriction During Pregnancy

(2015) Koumei Shirasuna et al.   ENDOCRINOLOGY

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells

(2015) Jonathan L. Schmid-Burgk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation

(2015) KUANG PENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation

(2015) Gregory M. Orlowski et al.   JOURNAL OF IMMUNOLOGY

Increased expression of the NLRP3 inflammasome components in patients with Behçet’s disease

(2015) En Hyung Kim et al.   Journal of Inflammation-London

Wytyczne ESC dotyczące rozpoznawania i leczenia chorób osierdzia w 2015 roku

(2015) Yehuda Adler et al.   Kardiologia Polska

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

(2015) Lorenzo Sborgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages

(2015) Masashi Muroi et al.   TOXICOLOGY LETTERS

Endothelial NLRP3 Inflammasome Activation and Enhanced Neointima Formation in Mice by Adipokine Visfatin

(2014) Min Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

(2014) Roy Emanuel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Mitochondrial NLRP3 Protein Induces Reactive Oxygen Species to Promote Smad Protein Signaling and Fibrosis Independent from the Inflammasome

(2014) Nathan A. Bracey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cholesterol Crystals Induce Complement-Dependent Inflammasome Activation and Cytokine Release

(2014) E. O. Samstad et al.   JOURNAL OF IMMUNOLOGY

Cardiac Fibroblasts Contribute to Myocardial Dysfunction in Mice with Sepsis: The Role of NLRP3 Inflammasome Activation

(2014) Wenbo Zhang et al.   PLoS One

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

Inhibition of reactive oxygen species in hypothalamic paraventricular nucleus attenuates the renin–angiotensin system and proinflammatory cytokines in hypertension

(2014) Qing Su et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of Interleukin-1 Blockade With Anakinra on Adverse Cardiac Remodeling and Heart Failure After Acute Myocardial Infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) Pilot Study]

(2013) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Prognostic impact of systemic inflammatory diseases in elderly patients with congestive heart failure

(2013) T. Burkard et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II–Induced Inflammation and Cardiac Fibrosis

(2012) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice

(2012) Fumitake Usui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblasts in post-infarction inflammation and cardiac repair

(2012) Wei Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice

(2012) Jessica Gage et al.   CANADIAN JOURNAL OF CARDIOLOGY

The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops

(2012) Chen Li et al.   CARDIOVASCULAR PATHOLOGY

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

(2012) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease

(2012) Stefan M. Nidorf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure

(2012) Benjamin W. Van Tassell et al.   PLoS One

IL1B and VWF Variants Are Associated With Fibrinolytic Early Recanalization in Patients With Ischemic Stroke

(2012) Israel Fernández-Cadenas et al.   STROKE

Monocytic microparticles activate endothelial cells in an IL-1 -dependent manner

(2011) J.-G. Wang et al.   BLOOD

Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer

(2011) Jing Wu et al.   CANCER LETTERS

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Molecular Imaging Insights Into Early Inflammatory Stages of Arterial and Aortic Valve Calcification

(2011) Sophie E.P. New et al.   CIRCULATION RESEARCH

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

Endothelial progenitor cells as therapeutic agents in the microcirculation: An update

(2010) Claudio Napoli et al.   ATHEROSCLEROSIS

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nadph Oxidase Mediates Striatal Neuronal Injury after Transient Global Cerebral Ischemia

(2010) Hideyuki Yoshioka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation

(2010) George S. Abela   Journal of Clinical Lipidology

Dilated cardiomyopathy

(2010) John Lynn Jefferies et al.   LANCET

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Pathophysiology and epidemiology of abdominal aortic aneurysms

(2010) Ian M. Nordon et al.   Nature Reviews Cardiology

Diabetic cardiomyopathy, causes and effects

(2010) Sihem Boudina et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes

(2009) George S. Abela et al.   AMERICAN JOURNAL OF CARDIOLOGY

Generation and Biological Activities of Oxidized Phospholipids

(2009) Valery N. Bochkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart

(2009) Soban Umar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Inflammatory Biomarkers in Heart Failure Revisited: Much More than Innocent Bystanders

(2009) Stephan von Haehling et al.   Heart Failure Clinics

Circulating interleukin-18 concentrations and a loss-of-function P2X7 polymorphism in heart failure

(2008) Guy D. Eslick et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Cardiac Remodeling in Obesity

(2008) E. Dale Abel et al.   PHYSIOLOGICAL REVIEWS

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA