NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

Jnk1Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null MiceHighlights

(2016) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y2in MiceHighlights

(2016) Peter Stachon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression

(2016) Alexandra Lindau et al.   BASIC RESEARCH IN CARDIOLOGY

The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux

(2016) Jordan R. Yaron et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating microRNA-192 as a diagnostic biomarker in human chronic lymphocytic leukemia

(2016) S Fathullahzadeh et al.   CANCER GENE THERAPY

Circulating microRNA: a new candidate for diagnostic biomarker in neuroblastoma

(2016) M Mohammadi et al.   CANCER GENE THERAPY

Glioblastoma: exosome and microRNA as novel diagnosis biomarkers

(2016) L Saadatpour et al.   CANCER GENE THERAPY

The kinase activity of PKR represses inflammasome activity

(2016) Howard CH Yim et al.   CELL RESEARCH

Epi-Drugs and Epi-miRs: Moving Beyond Current Cancer Therapies

(2016) Reza Salarinia et al.   CURRENT CANCER DRUG TARGETS

Circulating microRNAs in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers

(2016) Hamid Mirzaei et al.   CURRENT PHARMACEUTICAL DESIGN

Curcumin: A new candidate for melanoma therapy?

(2016) Hamed Mirzaei et al.   INTERNATIONAL JOURNAL OF CANCER

SiRNA and epigenetic aberrations in ovarian cancer

(2016) HamidReza Mirzaei et al.   Journal of Cancer Research and Therapeutics

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice

(2015) Chang Hyun Byon et al.   ATHEROSCLEROSIS

Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis

(2015) Yang Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation

(2015) S. Chen et al.   BLOOD

Inflammation and Immunity in Diseases of the Arterial Tree: Players and Layers

(2015) P. Libby et al.   CIRCULATION RESEARCH

NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice

(2015) Heike Langbein et al.   EUROPEAN HEART JOURNAL

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation

(2015) KUANG PENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation

(2015) Mandar Bawadekar et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

(2015) Liang Feng et al.   Journal of Neuroinflammation

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Perception of self: distinguishing autoimmunity from autoinflammation

(2015) Tessa S. van Kempen et al.   Nature Reviews Rheumatology

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

Protective Role for Toll-Like Receptor-9 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

(2014) Christine Koulis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis

(2014) Z. Ding et al.   CARDIOVASCULAR RESEARCH

NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases

(2014) Balázs Rada et al.   INFLAMMATION RESEARCH

NLRP1 inflammasome, and not NLRP3, is the key in the shift to proinflammatory state on endothelial cells in peripheral arterial disease

(2014) Silvia Bleda et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation

(2014) Masahiro Okada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1β Production

(2014) Kuo-Feng Hua et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

(2014) Fei Zheng et al.   MEDIATORS OF INFLAMMATION

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NLRP3 Gene Silencing Ameliorates Diabetic Cardiomyopathy in a Type 2 Diabetes Rat Model

(2014) Beibei Luo et al.   PLoS One

MicroRNA-223 coordinates cholesterol homeostasis

(2014) Kasey C. Vickers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications

(2014) Dmitry A. Chistiakov et al.   Biomed Research International

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2

(2013) Sayantani Bandyopadhyay et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

CD36: linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis

(2013) Cécile Oury   Cellular & Molecular Immunology

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet

(2013) Islam N. Mohamed et al.   DIABETOLOGIA

Inflammasomes: sensors of metabolic stresses for vascular inflammation 

(2013) Xiao-feng Yang   Frontiers in Bioscience-Landmark

NLRP3 Inflammasomes Show High Expression in Aorta of Patients with Atherosclerosis

(2013) Fei Zheng et al.   Heart Lung and Circulation

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Thioredoxin-interacting Protein Mediates High Glucose-induced Reactive Oxygen Species Generation by Mitochondria and the NADPH Oxidase, Nox4, in Mesangial Cells

(2013) Anu Shah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

(2013) Pieter J. Bakker et al.   KIDNEY INTERNATIONAL

Pyroptosis: An inflammatory cell death implicates in atherosclerosis

(2013) Wei Chang et al.   MEDICAL HYPOTHESES

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Kinases conquer the inflammasomes

(2013) Konstantin Neumann et al.   NATURE IMMUNOLOGY

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

MicroRNA-18a Attenuates DNA Damage Repair through Suppressing the Expression of Ataxia Telangiectasia Mutated in Colorectal Cancer

(2013) Chung-Wah Wu et al.   PLoS One

Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis

(2013) David Freeman et al.   PLoS One

Oxidized Low Density Lipoprotein Induced Caspase-1 Mediated Pyroptotic Cell Death in Macrophages: Implication in Lesion Instability?

(2013) Jing Lin et al.   PLoS One

Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome

(2013) Yang Xiang et al.   PLoS One

TXNIP shuttling: missing link between oxidative stress and inflammasome activation

(2013) Troy Lane et al.   Frontiers in Physiology

HMGB1 Promotes the Synthesis of Pro-IL-1β and Pro-IL-18 by Activation of p38 MAPK and NF-κB Through Receptors for Advanced Glycation End-products in Macrophages

(2012) Qiang He et al.   Asian Pacific Journal of Cancer Prevention

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

PKR stirs up inflammasomes

(2012) H James Stunden et al.   CELL RESEARCH

Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7

(2012) Jamal Hussen et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

IRE1, a Double-Edged Sword in Pre-miRNA Slicing and Cell Death

(2012) Justin Hassler et al.   DEVELOPMENTAL CELL

TLR-induced NF-κB activation regulates NLRP3 expression in murine macrophages

(2012) Yu Qiao et al.   FEBS LETTERS

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

(2012) Joshua N. Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

eNOS Protects from Atherosclerosis Despite Relevant Superoxide Production by the Enzyme in apoE−/− Mice

(2012) Padmapriya Ponnuswamy et al.   PLoS One

ER Stress Activates NF-κB by Integrating Functions of Basal IKK Activity, IRE1 and PERK

(2012) Arvin B. Tam et al.   PLoS One

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors

(2012) Manuela Rossol et al.   Nature Communications

Apoptosis Signal–Regulating Kinase 1 Deficiency Accelerates Hyperlipidemia-Induced Atheromatous Plaques via Suppression of Macrophage Apoptosis

(2011) Sohsuke Yamada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thioredoxin-Interacting Protein Mediates TRX1 Translocation to the Plasma Membrane in Response to Tumor Necrosis Factor-α

(2011) Cameron World et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Endothelial and Macrophage-Specific Deficiency of P38α MAPK Does Not Affect the Pathogenesis of Atherosclerosis in ApoE−/− Mice

(2011) Rozina Kardakaris et al.   PLoS One

Endoplasmic-Reticulum Calcium Depletion and Disease

(2011) D. Mekahli et al.   Cold Spring Harbor Perspectives in Biology

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

Mechanisms of LDL oxidation

(2010) Hiroshi Yoshida et al.   CLINICA CHIMICA ACTA

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: Caspase-1 Independent IL-1  Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

(2010) K. D. Mayer-Barber et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Reactive oxygen species-independent activation of the IL-1  inflammasome in cells from patients with chronic granulomatous disease

(2010) F. L. van de Veerdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway

(2010) Takumi Chinen et al.   TOXICOLOGY LETTERS

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice

(2009) Courtney P. Judkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Oxidative Stress and Mitochondrial Dysfunction in Atherosclerosis: Mitochondria-Targeted Antioxidants as Potential Therapy

(2009) V. Victor et al.   CURRENT MEDICINAL CHEMISTRY

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein Kinase PKR-Dependent Activation of Mitogen-Activated Protein Kinases Occurs through Mitochondrial Adapter IPS-1 and Is Antagonized by Vaccinia Virus E3L

(2009) P. Zhang et al.   JOURNAL OF VIROLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE