Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases

NLRP3: A promising therapeutic target for autoimmune diseases

(2018) Hui-Hui Shen et al.   AUTOIMMUNITY REVIEWS

Chaihu-shugan san inhibits inflammatory response to improve insulin signaling in liver and prefrontal cortex of CUMS rats with glucose intolerance

(2018) Ke-Ke Jia et al.   BIOMEDICINE & PHARMACOTHERAPY

Principles of inflammasome priming and inhibition: Implications for psychiatric disorders

(2018) Francis J. Herman et al.   BRAIN BEHAVIOR AND IMMUNITY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Regulation of primary microRNA processing

(2018) Antoine Creugny et al.   FEBS LETTERS

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression

(2018) Mi Jeong Heo et al.   GUT

The anti-inflammatory effect of microRNA-383-3p interacting with IL1R2 against homocysteine-induced endothelial injury in rat coronary arteries

(2018) Zheng Lian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis

(2018) Zhiqiang Pan et al.   Journal of Neuroinflammation

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

(2018) Di Chen et al.   Journal of Neuroinflammation

Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review

(2018) Yue Lang et al.   MEDIATORS OF INFLAMMATION

A Half-Century History of Applications of Antisense Oligonucleotides in Medicine, Agriculture and Forestry: We Should Continue the Journey

(2018) Volodymyr Oberemok et al.   MOLECULES

PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs

(2018) Kyle A. Cottrell et al.   Nature Communications

MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis

(2018) Peng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice

(2018) Ming-lei Chen et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

MicroRNA-495 Ameliorates Cardiac Microvascular Endothelial Cell Injury and Inflammatory Reaction by Suppressing the NLRP3 Inflammasome Signaling Pathway

(2018) Tao  Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3

(2017) Jun Lou et al.   EXPERIMENTAL CELL RESEARCH

Fructose downregulates miR-330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin

(2017) Ting-Ting Gu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

T cells from patients with Parkinson’s disease recognize α-synuclein peptides

(2017) David Sulzer et al.   NATURE

An integrated expression atlas of miRNAs and their promoters in human and mouse

(2017) Derek de Rie et al.   NATURE BIOTECHNOLOGY

miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions

(2017) Chih-Hung Chou et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson’s disease by targeting Nlrp3

(2017) Dongsheng Li et al.   Human Cell

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

Inflammasomes in Inflammation-Induced Cancer

(2017) Chu Lin et al.   Frontiers in Immunology

miR-148a-3p overexpression contributes to glomerular cell proliferation by targeting PTEN in lupus nephritis

(2016) Liu Qingjuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes

(2016) Xiao-Feng Li et al.   JOINT BONE SPINE

Dicer and microRNA expression in multiple sclerosis and response to interferon therapy

(2016) William J. Magner et al.   JOURNAL OF NEUROIMMUNOLOGY

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms

(2016) Sherry Freiesleben et al.   Scientific Reports

The Inflammasomes and Autoinflammatory Syndromes

(2015) Lori Broderick et al.   Annual Review of Pathology-Mechanisms of Disease

NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

(2015) Sunny Malhotra et al.   BRAIN

Genetic Association ofMiR-146awith Multiple Sclerosis Susceptibility in the Chinese Population

(2015) You Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

(2015) Paul J. Baker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377

(2015) Wei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing–remitting multiple sclerosis

(2015) Maryam Ahmadian-Elmi et al.   IMMUNOGENETICS

MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers

(2015) Isabelle Duroux-Richard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity

(2015) Ivan Kiselev et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is the microRNA-146a (rs2910164) polymorphism associated with rheumatoid arthritis? Association of microRNA-146a (rs2910164) polymorphism and rheumatoid arthritis could depend on gender

(2015) Xindie Zhou et al.   JOINT BONE SPINE

MicroRNA-7/NF-κB signaling regulatory feedback circuit regulates gastric carcinogenesis

(2015) Xiao-Di Zhao et al.   JOURNAL OF CELL BIOLOGY

Mycophenolic acid upregulates miR-142-3P/5P and miR-146a in lupus CD4+T cells

(2015) Q Tang et al.   LUPUS

Downregulated expression of miR-155, miR-17, and miR-181b, and upregulated expression of activation-induced cytidine deaminase and interferon-α in PBMCs from patients with SLE

(2015) Hagime Kaga et al.   Modern Rheumatology

MicroRNA-7 Enhances Subventricular Zone Neurogenesis by Inhibiting NLRP3/Caspase-1 Axis in Adult Neural Stem Cells

(2015) Zheng Fan et al.   MOLECULAR NEUROBIOLOGY

miRNA in multiple sclerosis: search for novel biomarkers

(2015) Roopali Gandhi   Multiple Sclerosis Journal

miRWalk2.0: a comprehensive atlas of microRNA-target interactions

(2015) Harsh Dweep et al.   NATURE METHODS

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA expression is highly sensitive to a drug therapy in Parkinson's disease

(2015) Anelya Kh. Alieva et al.   PARKINSONISM & RELATED DISORDERS

Prediction of treatment response to adalimumab: a double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis

(2015) S B Krintel et al.   PHARMACOGENOMICS JOURNAL

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plasma microRNA expression profiles in Chinese patients with rheumatoid arthritis

(2015) Wenhong Wang et al.   Oncotarget

miRNA in multiple sclerosis: search for novel biomarkers

(2015) Roopali Gandhi   Multiple Sclerosis Journal

Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b

(2015) Jens Ingwersen et al.   Annals of Clinical and Translational Neurology

Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis

(2014) Qihui Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production

(2014) M.-C. Lu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

HITS-CLIP and PAR-CLIP Advance Viral MiRNA Targetome Analysis

(2014) Irina Haecker et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota

(2014) N. Gagliani et al.   INTERNATIONAL IMMUNOLOGY

Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis

(2014) JD Ji et al.   LUPUS

Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation

(2014) Hayatoshi Shibuya et al.   Modern Rheumatology

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

(2014) Stephen W. Eichhorn et al.   MOLECULAR CELL

Decreased miR-146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1型糖尿病患者外周血单个核细胞miR-146表达下调与胰岛持续免疫失衡相关

(2014) Minglan Yang et al.   Journal of Diabetes

Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4+T Cells of Patients with Relapsing-Remitting Multiple Sclerosis

(2014) Maria Meira et al.   Journal of Immunology Research

IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance

(2014) Ajay Jain et al.   Frontiers in Immunology

miR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization

(2013) Craig S. Moore et al.   ANNALS OF NEUROLOGY

MicroRNA overexpression increases cortical neuronal vulnerability to injury

(2013) Jessie S. Truettner et al.   BRAIN RESEARCH

Overexpression of microRNAs-155 and 21 targeting mismatch repair proteins in inflammatory bowel diseases

(2013) M. Svrcek et al.   CARCINOGENESIS

Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

(2013) Li Long et al.   Clinical & Developmental Immunology

MicroRNA Expression Changes during Interferon-Beta Treatment in the Peripheral Blood of Multiple Sclerosis Patients

(2013) Michael Hecker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients

(2013) Madhan Thamilarasan et al.   Journal of Neuroinflammation

Deregulated NLRP3 and NLRP1 Inflammasomes and Their Correlations with Disease Activity in Systemic Lupus Erythematosus

(2013) Q. Yang et al.   JOURNAL OF RHEUMATOLOGY

Novel specific microRNA biomarkers in idiopathic inflammatory bowel disease unrelated to disease activity

(2013) Jingmei Lin et al.   MODERN PATHOLOGY

Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis

(2013) Chiara Fenoglio et al.   Multiple Sclerosis Journal

Diversifying microRNA sequence and function

(2013) Stefan L. Ameres et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

(2013) Gaia Codolo et al.   PLoS One

Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection

(2013) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

A Novel p53/microRNA-22/Cyr61 Axis in Synovial Cells Regulates Inflammation in Rheumatoid Arthritis

(2013) Jinpiao Lin et al.   Arthritis & Rheumatology

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene

(2012) S E Löfgren et al.   GENES AND IMMUNITY

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Circulating MicroRNA in inflammatory bowel disease

(2012) Archanioti Paraskevi et al.   Journal of Crohns & Colitis

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

Circulating microRNAs involved in multiple sclerosis

(2012) Sue Rutherford Siegel et al.   MOLECULAR BIOLOGY REPORTS

The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: a meta-analysis

(2012) J. Pakpoor et al.   Multiple Sclerosis Journal

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis

(2012) JIANXIN LU et al.   NEPHROLOGY

Damage Associated Molecular Pattern Molecule-Induced microRNAs (DAMPmiRs) in Human Peripheral Blood Mononuclear Cells

(2012) Sebnem Unlu et al.   PLoS One

Sphingosine kinase 1 in viral infections

(2012) Jillian M. Carr et al.   REVIEWS IN MEDICAL VIROLOGY

Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients

(2012) Heba Ragaee Abdelhakam Aboelenein et al.   RHEUMATOLOGY INTERNATIONAL

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Expression of miR-146a and miR-155 in the urinary sediment of systemic lupus erythematosus

(2011) Gang Wang et al.   CLINICAL RHEUMATOLOGY

MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function

(2011) Elena Miñones-Moyano et al.   HUMAN MOLECULAR GENETICS

Identification of blood microRNAs associated to Parkinsońs disease

(2011) Regina Margis et al.   JOURNAL OF BIOTECHNOLOGY

Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome

(2011) R. TERUEL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

MicroRNAs in inflammation and immune responses

(2011) J Contreras et al.   LEUKEMIA

Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis

(2011) Chiara Fenoglio et al.   NEUROSCIENCE LETTERS

Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis

(2011) Anne Waschbisch et al.   PLoS One

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes

(2010) Shintaro Iwasaki et al.   MOLECULAR CELL

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Making RISC

(2010) Tomoko Kawamata et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanisms of deadenylation-dependent decay

(2010) Chyi-Ying A. Chen et al.   Wiley Interdisciplinary Reviews-RNA

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages

(2009) Ting Chen et al.   CARDIOVASCULAR RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-κB1

(2009) Li-Min Guo et al.   FEBS Journal

Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

(2009) Sung Wook Chi et al.   NATURE

Expression of microRNA-146 in rheumatoid arthritis synovial tissue

(2008) Tomoyuki Nakasa et al.   ARTHRITIS AND RHEUMATISM

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Biomarkers in osteoarthritis

(2008) Frances MK Williams et al.   ARTHRITIS RESEARCH & THERAPY

Experimental validation of miRNA targets

(2007) Donald E. Kuhn et al.   METHODS