Emerging roles of ferroptosis in cardiovascular diseases

Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study

(2022) Jiaxin Fan et al.   BMC GENOMICS

Protective Effect of Qiliqiangxin against Doxorubicin-Induced Cardiomyopathy by Suppressing Excessive Autophagy and Apoptosis

(2022) Yating Qin et al.   Cardiovascular Therapeutics

Endothelial MicroRNA-483-3p Is Hypertension-Protective

(2022) Fenqing Shang et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis due to Cystathionine γ Lyase/Hydrogen Sulfide Downregulation Under High Hydrostatic Pressure Exacerbates VSMC Dysfunction

(2022) Ruxi Jin et al.   Frontiers in Cell and Developmental Biology

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

(2022) Zhenzhou Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Up-regulation of IRF3 is required for docosahexaenoic acid suppressing ferroptosis of cardiac microvascular endothelial cells in cardiac hypertrophy rat

(2022) Pilong Shi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impact of Exercise on Cerebrovascular Physiology and Risk of Stroke

(2022) Justin A. Edward et al.   STROKE

Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation

(2022) Shan-Shan Xie et al.   Scientific Reports

Pyroptosis: Role and Mechanisms in Cardiovascular Disease

(2022) Xinzhe Chen et al.   Frontiers in Cardiovascular Medicine

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury

(2021) Aleksandra Stamenkovic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

(2021) Li-Fei Luo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PDSS2 inhibits the ferroptosis of vascular endothelial cells in atherosclerosis via activating Nrf2

(2021) Kai Yang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Ferroptosis and its emerging roles in cardiovascular diseases

(2021) Ning Li et al.   PHARMACOLOGICAL RESEARCH

SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18

(2021) Guangming Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin

(2021) Vincenzo Quagliariello et al.   Cardiovascular Diabetology

SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis

(2021) Xiyu Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox‐LDL through miR‑326‐3p/VAMP3 axis in atherosclerosis

(2021) Ruogu Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Apoptosis, Autophagy, Necrosis and Their Multi Galore Crosstalk in Neurodegeneration

(2021) Suraiya Saleem   NEUROSCIENCE

The Role of Alpha-1-Acid Glycoprotein in the Diagnosis and Treatment of Crush Syndrome-Induced Acute Kidney Injury

(2021) Qi Lv et al.   SHOCK

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

(2021) Yi Yu et al.   Cell Death Discovery

The Link Between Ferroptosis and Cardiovascular Diseases: A Novel Target for Treatment

(2021) Huilin Hu et al.   Frontiers in Cardiovascular Medicine

TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

(2021) Jingfa Zhang et al.   EXPERIMENTAL CELL RESEARCH

Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis

(2021) Ting Li et al.   GENE

Molecular mechanisms and consequences of mitochondrial permeability transition

(2021) Massimo Bonora et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke

(2021) Chong Li et al.   PHARMACOLOGICAL RESEARCH

Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases

(2021) Meng-Yi Luo et al.   Frontiers in Cell and Developmental Biology

Neutrophil-like cell membrane-coated siRNA of lncRNA AABR07017145.1 therapy for cardiac hypertrophy via inhibiting ferroptosis of CMECs

(2021) Pilong Shi et al.   Molecular Therapy-Nucleic Acids

Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction

(2020) Bita Behrouzi et al.   BASIC RESEARCH IN CARDIOLOGY

Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator

(2020) Yu-Jing He et al.   BIOMATERIALS

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner

(2020) Chunyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

(2020) Chunyan Wang et al.   Molecular Medicine Reports

Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice

(2020) Yufang Song et al.   CELL BIOLOGY AND TOXICOLOGY

Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury

(2020) Li-Qun Lu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell

(2020) Tao Bai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion

(2020) Li-Jing Tang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

(2020) Junyan Wang et al.   Cell Death & Disease

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

Extracellular Vesicle-Mediated Vascular Cell Communications in Hypertension: Mechanism Insights and Therapeutic Potential of ncRNAs

(2020) Ji-Ru Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

(2020) Huimei Zang et al.   DIABETES

The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection

(2020) Tanya Ravingerová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes

(2020) Nian Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Simultaneous molecular MRI of extracellular matrix collagen and inflammatory activity to predict abdominal aortic aneurysm rupture

(2020) Lisa C. Adams et al.   Scientific Reports

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis

(2020) Yasir Abdul et al.   Translational Stroke Research

Fatal lymphocytic cardiac damage in coronavirus disease 2019 (COVID‐19): autopsy reveals a ferroptosis signature

(2020) Werner Jacobs et al.   ESC Heart Failure

Site-specific peroxidation modulates lipid bilayer mechanics

(2020) Choon-Peng Chng et al.   Extreme Mechanics Letters

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary

(2019) Donna K. Arnett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Current Status and Challenges of NRF2 as a Potential Therapeutic Target for Diabetic Cardiomyopathy

(2019) Zhi-Dong Ge et al.   International Heart Journal

miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis

(2019) Feng-Jun Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanism and intervention measures of iron side effects on the intestine

(2019) Xiao Qi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

(2019) Xiaoqing Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

(2019) Dominic P. Del Re et al.   PHYSIOLOGICAL REVIEWS

Mitochondria regulation in ferroptosis

(2019) Hai Wang et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1

(2019) Hironari Nishizawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

(2019) Yansheng Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation

(2019) Sofia-Iris Bibli et al.   Redox Biology

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges

(2018) Shuaibo Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anemia and Iron Deficiency in Heart Failure

(2018) Inder S. Anand et al.   CIRCULATION

N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why

(2018) Giancarlo Aldini et al.   FREE RADICAL RESEARCH

Involvement of Smad3 pathway in atrial fibrosis induced by elevated hydrostatic pressure

(2018) Wei Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nrf2 at the heart of oxidative stress and cardiac protection

(2018) Qin M. Chen et al.   PHYSIOLOGICAL GENOMICS

LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription

(2018) Cui-Yun Liu et al.   Nature Communications

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Iron catalysis of lipid peroxidation in ferroptosis: Regulated enzymatic or random free radical reaction?

(2018) D.A. Stoyanovsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

(2018) Andrew Hinman et al.   PLoS One

Mitochondrial Iron in Human Health and Disease

(2018) Diane M. Ward et al.   Annual Review of Physiology

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats

(2017) Nawal M. Al-Rasheed et al.   Oxidative Medicine and Cellular Longevity

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Identification of baicalein as a ferroptosis inhibitor by natural product library screening

(2016) Yangchun Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223

(2016) Kun Wang et al.   EUROPEAN HEART JOURNAL

Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects

(2016) Francisco Olivas-Aguirre et al.   MOLECULES

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Aortic Iron Overload With Oxidative Stress and Inflammation in Human and Murine Abdominal Aortic Aneurysm

(2015) H. Sawada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Organizational Update: The World Health Organization Global Status Report on Noncommunicable Diseases 2014; One More Landmark Step in the Combat Against Stroke and Vascular Disease

(2015) S. Mendis et al.   STROKE

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury

(2015) Yuanyuan Zhao et al.   Stem Cells International

Structural basis of cell apoptosis and necrosis in TNFR signaling

(2014) Jing Huang et al.   APOPTOSIS

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Molecular mechanisms of diabetic cardiomyopathy

(2014) Heiko Bugger et al.   DIABETOLOGIA

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypertension in the US Black Population: Risk Factors, Complications, and Potential Impact of Central Aortic Pressure on Effective Treatment

(2012) Keith C. Ferdinand et al.   CARDIOVASCULAR DRUGS AND THERAPY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Cinnamaldehyde protects from the hypertension associated with diabetes

(2011) Hany M. El-Bassossy et al.   FOOD AND CHEMICAL TOXICOLOGY

Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2release from human arterial smooth muscle cells

(2011) Deidre L. Golej et al.   JOURNAL OF LIPID RESEARCH

Celastrol Attenuates Hypertension-Induced Inflammation and Oxidative Stress in Vascular Smooth Muscle Cells via Induction of Heme Oxygenase-1

(2010) X. Yu et al.   AMERICAN JOURNAL OF HYPERTENSION

Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart

(2010) Guangwu Wang et al.   CIRCULATION

Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma

(2010) Ling-Min Kong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

(2009) Stefan D. Anker et al.   NEW ENGLAND JOURNAL OF MEDICINE