Review
Nutrition & Dietetics
Yufei Chen, Xueting Li, Siyuan Wang, Ran Miao, Jiuchang Zhong
Summary: Iron plays a crucial role in the cardiovascular system, and dysregulation of iron metabolism and ferroptosis are involved in the pathogenesis of various cardiovascular diseases. Iron chelators and lipophilic antioxidants have been shown to inhibit ferroptosis and lipid peroxidation in atherosclerosis, cardiomyopathy, and hypertension. Inhibition of ferroptosis can alleviate cardiac impairments and fibrosis in hypertension by enhancing GPX4 signaling. Novel small molecules targeting ferroptosis may be effective in the treatment of cardiovascular diseases. This article summarizes the regulatory roles and underlying mechanisms of iron metabolism dysregulation and ferroptosis in cardiovascular diseases and suggests targeting iron metabolism and ferroptosis as potential therapeutic strategies.
Review
Cell Biology
Kai Chen, Xiaobing Jiang, Moxin Wu, Xianming Cao, Wendai Bao, Ling-Qiang Zhu
Summary: Ferroptosis is considered as a distinct mechanism in the pathogenesis of Alzheimer's disease, with involvement in key features of AD pathology. Inhibitors of ferroptosis show potential clinical benefits in both AD patients and mice models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Yunqing Chen, Hongyan Fan, Shijun Wang, Guanmin Tang, Changlin Zhai, Liang Shen
Summary: Ischemia-reperfusion (I/R) injury is a major cause of cell death and organ damage in various pathologies, and current treatment methods are limited. Ferroptosis, a newly discovered type of regulated cell death characterized by iron overload and lipid peroxidation accumulation, has been found to have a close association with I/R injury, making it a potential new therapeutic target. This review summarizes the current status of ferroptosis and explores its relationship with I/R injury, as well as potential treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Min Hong, Jiabing Rong, Xinran Tao, Yinchuan Xu
Summary: Ferroptosis is a type of programmed cell death characterized by iron-dependent lipid peroxidation, which differs from traditional cell death types in morphology, biochemistry, and genetics. It has been found to play a major role in cardiovascular diseases, and this review discusses its mechanisms and effects on the occurrence and development of such diseases, aiming to provide a new target for their prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Yang Zhang, Laiyun Xin, Mi Xiang, Chang Shang, Yuling Wang, Yan Wang, Xiangning Cui, Yingdong Lu
Summary: Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides and redox disequilibrium, with unique features compared to other forms of cell death. Metabolic disorders of amino acids, iron, and lipids play a significant role in the pathophysiology of cardiovascular diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Ying Yao, Bin Wang, Yanbiao Jiang, Hong Guo, Yulan Li
Summary: Ferroptosis is a regulated form of cell death that is mainly associated with iron-driven lipid peroxidation damage. It is regulated by iron homeostasis, redox balance, lipid metabolism, glutathione metabolism, and various disease signaling pathways. The occurrence of Ferroptosis has both hidden dangers and advantages in ovary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Changyong Wu, Suli Bao, Huang Sun, Xiaocui Chen, Lu Yang, Ruijie Li, Yunzhu Peng
Summary: The morbidity and mortality rates of cardiovascular diseases (CVDs) are increasing, and noncoding RNAs (ncRNAs) and a unique form of cell death called ferroptosis play critical roles in the development of CVDs.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Chih-Jan Ko, Shih-Ling Gao, Tsu-Kung Lin, Pei-Yi Chu, Hung-Yu Lin
Summary: Evidence suggests that ferroptosis plays a crucial role in the development of Parkinson's disease, causing cell death through iron-dependent lipid peroxidation and leading to membrane rupture and neuroinflammation. The sensitivity of ferroptosis is regulated by multiple aspects of iron metabolism, while its impact on the survival of dopaminergic neurons and microglial activity is significant for understanding the pathogenesis of PD.
Review
Chemistry, Medicinal
Li Liu, Liqi Li, Menghuan Li, Zhong Luo
Summary: Ferroptosis is a form of cell death that depends on iron ions and is closely related to autophagy. Autophagy promotes ferroptosis by degrading ferritin, leading to the accumulation of iron ions and lipid ROS, offering potential therapeutic opportunities for cancer treatment.
Review
Pharmacology & Pharmacy
Ning Li, Wenyang Jiang, Wei Wang, Rui Xiong, Xiaojing Wu, Qing Geng
Summary: Ferroptosis, a novel form of regulated cell death driven by iron-dependent lipid peroxidation, has been found to play a role in various cardiovascular diseases, but the specific mechanisms by which it contributes to the progression of cardiovascular diseases remain unclear.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yibo Liu, Yuanjian Fang, Zeyu Zhang, Yujie Luo, Anke Zhang, Cameron Lenahan, Sheng Chen
Summary: Stroke is a devastating neurological disease with high morbidity and mortality, and the mechanism of its pathological process remains unclear. Ferroptosis, a distinct form of cell death characterized by iron-dependent accumulation of lipid peroxides, has been shown to play a significant role in the pathological process of stroke.Understanding the relationship between ferroptosis and stroke may provide better therapeutic targets for treating this devastating disease.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Zhenzhen Chen, Youyou Yan, Chao Qi, Jia Liu, Longbo Li, Junnan Wang
Summary: Cardiovascular diseases are the leading cause of global mortality, and ferroptosis, a new type of cell death causing cell damage, plays a significant role in cardiac pathophysiology. Current research focuses on exploring how ferroptosis contributes to the development of atherosclerosis, myocardial infarction, heart failure, and other cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Environmental Sciences
Wenli Ding, Luxi Lin, Ke Yue, Yanfeng He, Bowen Xu, Aftab Shaukat, Shucheng Huang
Summary: Mycotoxin contamination poses a significant threat to food safety and human health. Understanding the mechanism of mycotoxin toxicity is crucial for detoxification. Ferroptosis, characterized by iron overload and accumulation of lipid reactive oxygen species (ROS) and depletion of glutathione (GSH), plays a role in organ damage from mycotoxin exposure, and natural antioxidants can alleviate mycotoxicosis and regulate ferroptosis. Chinese herbal medicine research on treating diseases through ferroptosis has gained attention. This article reviews the mechanism of ferroptosis, discusses its role in mycotoxicosis, and summarizes the current status of Chinese herbal interventions in regulating mycotoxicosis through ferroptosis, providing insights for future treatment strategies.
Review
Immunology
Hui Zhao, Cheng Tang, Miao Wang, Hongfang Zhao, Yan Zhu
Summary: This review discusses the role and mechanism of ferroptosis in rheumatoid arthritis (RA), and explores its potential and challenges as a new therapeutic strategy, providing new targets for the prevention and treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sarah El Hajj, Laetitia Canabady-Rochelle, Caroline Gaucher
Summary: Ferroptosis, driven by iron overload and lipid peroxidation, plays a key role in the development of diseases such as atherosclerosis, Alzheimer's, diabetes, cancer, and renal failure. The balance between intracellular oxidants and antioxidants is crucial in ferroptosis regulation. Induction and inhibition of ferroptosis are potential strategies for disease treatment, and drugs as well as natural bioactive compounds have been developed for this purpose. The antioxidant properties of bioactive peptides have been found to be related to ferroptosis regulation.
