Journal
CARDIOVASCULAR DRUGS AND THERAPY
Volume 36, Issue 1, Pages 157-172Publisher
SPRINGER
DOI: 10.1007/s10557-020-07080-z
Keywords
Hypertension; Endothelial cells; Vascular smooth muscle cells; Noncoding RNAs; Extracellular vesicles
Funding
- Fund of the National Natural Science Foundation of China [81700364]
- Jiangsu Natural Science Foundation [BK20170179, BK20191138]
- Jiangsu Province Department of Science and Technology [BE2020634]
- Key Young Medical Talent Project of Jiangsu Health Commission [QNRC2016158]
- China Postdoctoral Science Foundation [2017M611688]
- Jiangsu Postdoctoral Science Foundation [1701062C]
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Hypertension is a common and difficult-to-treat chronic disease. This study investigates the interactions between vascular cells and finds that extracellular vesicle-carried ncRNAs play an important role in hypertension and vascular remodeling. This finding may provide new clinical targets for hypertension treatment.
Hypertension, a chronic and progressive disease, is an outstanding public health issue that affects nearly 40% of the adults worldwide. The increasing prevalence of hypertension is one of the leading causes of cardiovascular morbidity and mortality. Despite of the available treatment medications, an increasing number of hypertensive individuals continues to have uncontrolled blood pressure. In the vasculature, endothelial cells, vascular smooth muscle cells (VSMCs), and adventitial fibroblasts play a fundamental role in vascular homeostasis. The aberrant interactions between vascular cells might lead to hypertension and vascular remodeling. Identification of the precise mechanisms of vascular remodeling may be highly required to develop effective therapeutic approaches for hypertension. Recently, extracellular vesicle-mediated transfer of proteins or noncoding RNAs (ncRNAs) between vascular cells holds promise for the treatment of hypertension. Especially, extracellular vesicle-packaging ncRNAs have gained enormous attention of basic and clinical scientists because of their tremendous potential to act as novel clinical biomarkers and therapeutic targets of hypertension. Here we will discuss the current findings focusing on the emerging roles of extracellular vesicle-carrying ncRNAs in the pathologies of hypertension and its associated vascular remodeling. Furthermore, we will highlight the potential of extracellular vesicles and ncRNAs as biomarkers and therapeutic targets for hypertension. The future research directions on the challenges and perspectives of extracellular vesicles and ncRNAs in hypertensive vascular remodeling are also proposed.
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