The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection

Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation

(2020) Zhi-Min Sun et al.   LIFE SCIENCES

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

Ferroportin disease: A novel SLC40A1 mutation

(2020) Giulia Ravasi et al.   DIGESTIVE AND LIVER DISEASE

mPTP Proteins Regulated by Streptozotocin-Induced Diabetes Mellitus Are Effectively Involved in the Processes of Maintaining Myocardial Metabolic Adaptation

(2020) Natalia Andelova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner

(2020) Chunyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dexmedetomidine alleviates H2O2-induced oxidative stress and cell necroptosis through activating of α2-adrenoceptor in H9C2 cells

(2020) Wenchao Yin et al.   MOLECULAR BIOLOGY REPORTS

Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury

(2020) Chunyan Wang et al.   Molecular Medicine Reports

L-Carnitine Reduces Myocardial Oxidative Stress and Alleviates Myocardial Ischemia-Reperfusion Injury by Activating Nuclear Transcription-Related Factor 2 (Nrf2)/Heme Oxygenase-1 (HO-1) Signaling Pathway

(2020) Tana Zhao et al.   MEDICAL SCIENCE MONITOR

Iron Metabolism in Obesity and Metabolic Syndrome

(2020) Álvaro González-Domínguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic effect of carbon monoxide‑releasing molecule‑3 on acute lung injury after hemorrhagic shock and resuscitation

(2019) Yuta Kumada et al.   Experimental and Therapeutic Medicine

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sevoflurane postconditioning is not mediated by ferritin accumulation and cannot be rescued by simvastatin in isolated streptozotocin-induced diabetic rat hearts

(2019) Hilbert Grievink et al.   PLoS One

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

(2019) Dong Xu et al.   MOLECULES

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction

(2019) Francesca Vinchi et al.   EUROPEAN HEART JOURNAL

Iron Metabolism, Hepcidin, and Mortality (the Ludwigshafen Risk and Cardiovascular Health Study)

(2019) Tanja B. Grammer et al.   CLINICAL CHEMISTRY

Iron and the heart: A paradigm shift from systemic to cardiomyocyte abnormalities

(2019) Aleksandra Paterek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferritin Genes Overexpression in PBMC and a Rise in Exercise Performance as an Adaptive Response to Ischaemic Preconditioning in Young Men

(2019) Jan Mieszkowski et al.   Biomed Research International

Keeping heart homeostasis in check through the balance of iron metabolism

(2019) Driton Vela   Acta Physiologica

ACG Clinical Guideline

(2019) Kris V. Kowdley et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Different signalling in infarcted and non‐infarcted areas of rat failing hearts: A role of necroptosis and inflammation

(2019) Martin Lichý et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hypobaric hypoxia regulates iron metabolism in rats

(2019) Yaru Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury

(2019) Liangtong Li et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Iron Overload Damages the Endothelial Mitochondria via the ROS/ADMA/DDAHII/eNOS/NO Pathway

(2019) Huan He et al.   Oxidative Medicine and Cellular Longevity

Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes

(2019) Tae-Jun Park et al.   Cell Death & Disease

Galanthamine improves myocardial ischemia-reperfusion-induced cardiac dysfunction, endoplasmic reticulum stress-related apoptosis, and myocardial fibrosis by suppressing AMPK/Nrf2 pathway in rats

(2019) Xiaolin Hou et al.   Annals of Translational Medicine

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

(2019) Yansheng Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crocetin alleviates myocardial ischemia/reperfusion injury by regulating inflammation and the unfolded protein response

(2019) Ming Yang et al.   Molecular Medicine Reports

Insight into the mechanism of ferroptosis inhibition by ferrostatin-1

(2019) Giovanni Miotto et al.   Redox Biology

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interplay of adipocyte and hepatocyte: Leptin upregulates hepcidin

(2018) Kiyoko Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function

(2018) Martijn F. Hoes et al.   EUROPEAN JOURNAL OF HEART FAILURE

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update

(2018) Richard Gordan et al.   HEART FAILURE REVIEWS

Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis

(2018) Shing Chan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Iron Deficiency in Heart Failure

(2018) Stephan von Haehling et al.   JACC-Heart Failure

Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice

(2017) Juthamas Khamseekaew et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The interplay between iron and oxygen homeostasis with a particular focus on the heart

(2017) Samira Lakhal-Littleton et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mössbauer Spectra of Mouse Hearts Reveal Age-dependent Changes in Mitochondrial and Ferritin Iron Levels

(2017) Joshua D. Wofford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anemia of Inflammation

(2017) Paula G. Fraenkel   MEDICAL CLINICS OF NORTH AMERICA

Iron accumulation, glutathione depletion, and lipid peroxidation must occur simultaneously during ferroptosis and are mutually amplifying events

(2017) Robert L. Bertrand   MEDICAL HYPOTHESES

Mitochondrial Iron Metabolism and Its Role in Neurodegeneration

(2017) Maxx P. Horowitz et al.   JOURNAL OF ALZHEIMERS DISEASE

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Getting to the “Heart” of Cardiac Disease by Decreasing Mitochondrial Iron

(2016) Hsiang-Chun Chang et al.   CIRCULATION RESEARCH

Heme Oxygenase-1 and Carbon Monoxide in the Heart

(2016) Leo E. Otterbein et al.   CIRCULATION RESEARCH

Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment–Elevation Myocardial Infarction and Adverse Left Ventricular RemodelingCLINICAL PERSPECTIVE

(2016) Heerajnarain Bulluck et al.   Circulation-Cardiovascular Imaging

Myocardial Hemorrhage After Acute Reperfused ST-Segment–Elevation Myocardial InfarctionCLINICAL PERSPECTIVE

(2016) David Carrick et al.   Circulation-Cardiovascular Imaging

Reduction in mitochondrial iron alleviates cardiac damage during injury

(2016) H.-C. Chang et al.   EMBO Molecular Medicine

Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure

(2016) Saba Haddad et al.   EUROPEAN HEART JOURNAL

Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis

(2016) Vojtech Melenovsky et al.   EUROPEAN JOURNAL OF HEART FAILURE

Necroptotic cell death in failing heart: relevance and proposed mechanisms

(2016) Adriana Adameova et al.   HEART FAILURE REVIEWS

Iron Deficiency Anemia

(2016) Sant-Rayn Pasricha et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Anaemia of Chronic Disease: An In-Depth Review

(2016) Anazoeze Jude Madu et al.   MEDICAL PRINCIPLES AND PRACTICE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects

(2016) Elena Gammella et al.   Oxidative Medicine and Cellular Longevity

Protection by Nitric Oxide Donors of Isolated Rat Hearts Is Associated with Activation of Redox Metabolism and Ferritin Accumulation

(2016) Hilbert Grievink et al.   PLoS One

Mitochondrial ferritin protects the murine myocardium from acute exhaustive exercise injury

(2016) Wenyue Wu et al.   Cell Death & Disease

Mitochondria and Iron: current questions

(2016) Bibbin T. Paul et al.   Expert Review of Hematology

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

(2016) Samira Lakhal-Littleton et al.   eLife

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Iron status and its association with coronary heart disease: Systematic review and meta-analysis of prospective studies

(2015) Sudeep Das De et al.   ATHEROSCLEROSIS

Hepcidin: regulation of the master iron regulator

(2015) Gautam Rishi et al.   BIOSCIENCE REPORTS

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Inflation with carbon monoxide in rat donor lung during cold ischemia phase ameliorates graft injury

(2015) Chao Meng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation

(2015) Darius Lane et al.   Nutrients

High Serum Iron Is Associated with Increased Cancer Risk

(2014) C. P. Wen et al.   CANCER RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

(2014) Douglas B. Kell et al.   Metallomics

A Review on Hemeoxygenase-2: Focus on Cellular Protection and Oxygen Response

(2014) Jorge Muñoz-Sánchez et al.   Oxidative Medicine and Cellular Longevity

Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload

(2013) J. Sripetchwandee et al.   Acta Physiologica

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Control of iron deficiency anemia in low- and middle-income countries

(2013) S.-R. Pasricha et al.   BLOOD

A Unified Model for Ferritin Iron Loading by the Catalytic Center: Implications for Controlling “Free Iron” during Oxidative Stress

(2013) Richard K. Watt   CHEMBIOCHEM

Magnetic resonance imaging-defined areas of microvascular obstruction after acute myocardial infarction represent microvascular destruction and haemorrhage

(2013) Lourens F.H.J. Robbers et al.   EUROPEAN HEART JOURNAL

Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction

(2013) Gervasio A. Lamas et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Carbon monoxide releasing molecule-2 attenuated ischemia/reperfusion-induced apoptosis in cardiomyocytes via a mitochondrial pathway

(2013) SHEN ZHAO et al.   Molecular Medicine Reports

The Bitter Fate of the Sweet Heart: Impairment of Iron Homeostasis in Diabetic Heart Leads to Failure in Myocardial Protection by Preconditioning

(2013) Vladimir Vinokur et al.   PLoS One

Ferroportin-mediated iron transport: Expression and regulation

(2012) Diane M. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial calcium uniporter blocker prevents cardiac mitochondrial dysfunction induced by iron overload in thalassemic mice

(2012) Sirinart Kumfu et al.   BIOMETALS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Effect of Iron Chelation on Myocardial Infarct Size and Oxidative Stress in ST-Elevation–Myocardial Infarction

(2012) William Chan et al.   Circulation-Cardiovascular Interventions

Cardiac Protection by Preconditioning Is Generated via an Iron-Signal Created by Proteasomal Degradation of Iron Proteins

(2012) Baruch E. Bulvik et al.   PLoS One

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export

(2012) Y. Ichikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium

(2011) Adam B. Stein et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Liver preconditioning induced by iron in a rat model of ischemia/reperfusion

(2011) Mónica Galleano et al.   LIFE SCIENCES

Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development

(2010) Stefania Recalcati et al.   ANTIOXIDANTS & REDOX SIGNALING

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium

(2010) Bela Juhasz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction

(2009) J. Ganame et al.   EUROPEAN HEART JOURNAL

Ferritins: A family of molecules for iron storage, antioxidation and more

(2008) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: Role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor

(2008) Suresh Varma Penumathsa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polyol pathway mediates iron-induced oxidative injury in ischemic–reperfused rat heart

(2008) Wai Ho Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypothermic preconditioning of endothelial cells attenuates cold-induced injury by a ferritin-dependent process

(2008) Michael A.J. Zieger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heart protection by ischemic preconditioning: A novel pathway initiated by iron and mediated by ferritin

(2008) Mordechai Chevion et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes

(2008) Shigemiki Omiya et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

3D morphology of the human hepatic ferritin mineral core: New evidence for a subunit structure revealed by single particle analysis of HAADF-STEM images

(2008) Ying-Hsi Pan et al.   JOURNAL OF STRUCTURAL BIOLOGY