Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

(2022) Carlo Angeletti et al.   iScience

Tripeptide IRW Upregulates NAMPT Protein Levels in Cells and Obese C57BL/6J Mice

(2021) Khushwant S. Bhullar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process

(2021) Fiqri D. Khaidizar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

(2021) Mihoko Yoshino et al.   SCIENCE

Potent Inhibition of Nicotinamide N-Methyltransferase by Alkene-Linked Bisubstrate Mimics Bearing Electron Deficient Aromatics

(2021) Yongzhi Gao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

(2021) Bagen Liao et al.   Journal of the International Society of Sports Nutrition

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

(2021) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration

(2021) Heather S Loring et al.   eLife

Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers

(2021) Roberto Campagna et al.   Cancers

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

(2020) Carlijn M E Remie et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside

(2020) Łukasz Mateuszuk et al.   BIOCHEMICAL PHARMACOLOGY

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

(2020) Eija Pirinen et al.   Cell Metabolism

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis

(2020) Nady Braidy et al.   EXPERIMENTAL GERONTOLOGY

NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging

(2020) Daniel C. Levine et al.   MOLECULAR CELL

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

(2020) Weiqi Hong et al.   Frontiers in Cell and Developmental Biology

Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment

(2020) Eun Seong Hwang et al.   Biomolecules

CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats

(2020) Yoshio Ogura et al.   Aging-US

Implications of NAD + boosters in translational medicine

(2020) Baeki E. Kang et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells

(2020) Xiaolu A. Cambronne et al.   TRENDS IN BIOCHEMICAL SCIENCES

Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the NAMPT-NAD Pathway

(2020) Weijie Xie et al.   Oxidative Medicine and Cellular Longevity

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Healthy Lifestyle Recommendations: Do the Beneficial Effects Originate from NAD+ Amount at the Cellular Level?

(2020) Borut Poljsak et al.   Oxidative Medicine and Cellular Longevity

Notoginseng leaf triterpenes ameliorates mitochondrial oxidative injury via the NAMPT-SIRT1/2/3 signaling pathways in cerebral ischemic model rats

(2020) Weijie Xie et al.   Journal of Ginseng Research

NAD+ metabolism governs the proinflammatory senescence-associated secretome

(2019) Timothy Nacarelli et al.   NATURE CELL BIOLOGY

Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study

(2019) C. F. Dolopikou et al.   EUROPEAN JOURNAL OF NUTRITION

The role of antioxidants in cancer, friends or foes?

(2019) B Poljsak et al.   CURRENT PHARMACEUTICAL DESIGN

Role of endothelial NAD+ deficiency in age-related vascular dysfunction

(2019) Anna Csicsar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

(2019) Claudia Chini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity

(2019) Yongzhi Gao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases

(2019) Keisuke Hikosaka et al.   NUTRITIONAL NEUROSCIENCE

Identification of evolutionary and kinetic drivers of NAD-dependent signaling

(2019) Mathias Bockwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Boosting NAD+ with a small molecule that activates NAMPT

(2019) Stephen J. Gardell et al.   Nature Communications

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

(2019) Dietrich Conze et al.   Scientific Reports

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

(2019) Yasir S. Elhassan et al.   Cell Reports

High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)

(2019) Rocco L. Policarpo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Yin and Yang: Why did evolution implement and preserve the circadian rhythmicity?

(2019) B. Poljsak et al.   MEDICAL HYPOTHESES

Cancer Etiology: A Metabolic Disease Originating from Life’s Major Evolutionary Transition?

(2019) B. Poljsak et al.   Oxidative Medicine and Cellular Longevity

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

(2019) Audrey Sambeat et al.   Nature Communications

High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet

(2019) Wenbiao Shi et al.   Nutrients

A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor

(2019) Judith Giroud-Gerbetant et al.   Molecular Metabolism

Loss of NAMPT in aging retinal pigment epithelium reduces NAD+ availability and promotes cellular senescence

(2018) Ravirajsinh N. Jadeja et al.   Aging-US

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease

(2018) Daniel S. Matasic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

(2018) Nady Braidy et al.   ANTIOXIDANTS & REDOX SIGNALING

Covalent inhibitors of nicotinamide N -methyltransferase (NNMT) provide evidence for target engagement challenges in situ

(2018) Hsin-Yu Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance

(2018) I.A. Kourtzidis et al.   EXPERIMENTAL PHYSIOLOGY

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

NAMPT-mediated NAD + biosynthesis is indispensable for adipose tissue plasticity and development of obesity

(2018) Karen Nørgaard Nielsen et al.   Molecular Metabolism

Vitamin B3 forms as precursors to NAD+: Are they safe?

(2018) B. Poljsak et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Homocysteine and age-associated disorders

(2018) E.A. Ostrakhovitch et al.   AGEING RESEARCH REVIEWS

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

(2017) Harshini Neelakantan et al.   JOURNAL OF MEDICINAL CHEMISTRY

NAD and the aging process: Role in life, death and everything in between

(2017) Claudia C.S. Chini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: Pathophysiological implications and therapeutic potential

(2016) Mathias Mericskay   Archives of Cardiovascular Diseases

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Why NAD + Declines during Aging: It’s Destroyed

(2016) Michael B. Schultz et al.   Cell Metabolism

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Restoring stem cells — all you need is NAD+

(2016) Lindsay E Wu et al.   CELL RESEARCH

Safety assessment of nicotinamide riboside, a form of vitamin B3

(2016) DB Conze et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Obesity Is Associated With Low NAD+/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins

(2016) Sakari Jukarainen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding

(2016) Janice E. Drew et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The NAD+ precursor nicotinamide riboside decreases exercise performance in rats

(2016) Ioannis A. Kourtzidis et al.   Journal of the International Society of Sports Nutrition

SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation

(2016) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

G6PD protects from oxidative damage and improves healthspan in mice

(2016) Sandrina Nóbrega-Pereira et al.   Nature Communications

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats

(2016) Gerard Aragonès et al.   Scientific Reports

The journey of resveratrol from yeast to human

(2016) Silvie Timmers et al.   Aging-US

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

(2016) Samuel A.J. Trammell et al.   Scientific Reports

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

(2015) Curt D. Haffner et al.   JOURNAL OF MEDICINAL CHEMISTRY

The renoprotective effect of curcumin in cisplatin-induced nephrotoxicity

(2015) Sıddık Ugur et al.   RENAL FAILURE

Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver

(2015) Aleix Ribas-Latre et al.   Scientific Reports

Endotoxemia, nutrition, and cardiometabolic disorders

(2014) K. A. Elisa Kallio et al.   ACTA DIABETOLOGICA

Nicotinamide and the skin

(2014) Andrew C Chen et al.   AUSTRALASIAN JOURNAL OF DERMATOLOGY

Inhibition of De Novo NAD + Synthesis by Oncogenic URI Causes Liver Tumorigenesis through DNA Damage

(2014) Krishna S. Tummala et al.   CANCER CELL

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis

(2014) Lindsay E. Wu et al.   CANCER CELL

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

(2014) Eija Pirinen et al.   Cell Metabolism

Circadian clock-mediated control of stem cell division and differentiation: beyond night and day

(2014) S. A. Brown   DEVELOPMENT

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

(2014) B. J. North et al.   EMBO JOURNAL

Partial Reversal of Skeletal Muscle Aging by Restoration of Normal NAD+ Levels

(2014) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Retinal Toxicity, in vivo and in vitro, Associated with Inhibition of Nicotinamide Phosphoribosyltransferase

(2014) Tanja S. Zabka et al.   TOXICOLOGICAL SCIENCES

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Nicotinamide riboside, a trace nutrient in foods, is a Vitamin B3 with effects on energy metabolism and neuroprotection

(2013) Yuling Chi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2013) Antonella Chillemi et al.   MOLECULAR MEDICINE

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

Emerging roles for post-transcriptional regulation in circadian clocks

(2013) Chunghun Lim et al.   NATURE NEUROSCIENCE

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

(2012) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

(2012) Chu-Xia Deng   International Journal of Biological Sciences

Fueling the flame: bioenergy couples metabolism and inflammation

(2012) T. F. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

(2012) R. Strong et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The dynamic regulation of NAD metabolism in mitochondria

(2012) Liana Roberts Stein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Flavonoids as inhibitors of human CD38

(2011) Esther Kellenberger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

(2011) Sergiy Libert et al.   CELL

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

NAD Blocks High Glucose Induced Mesangial Hypertrophy via Activation of the Sirtuins-AMPK-mTOR Pathway

(2011) Li Zhuo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives

(2011) Wu-Ping Sun et al.   HYPERTENSION RESEARCH

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

(2011) Kahlilia C Morris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Identification of NAD interacting residues in proteins

(2010) Hifzur R Ansari et al.   BMC BIOINFORMATICS

Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding

(2010) Gad Asher et al.   CELL

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

SIRT1 gene is associated with major depressive disorder in the Japanese population

(2010) Taro Kishi et al.   JOURNAL OF AFFECTIVE DISORDERS

Resveratrol, sirtuins, and the promise of a DR mimetic

(2010) Joseph A. Baur   MECHANISMS OF AGEING AND DEVELOPMENT

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

(2009) Kathryn Moynihan Ramsey et al.   AGING CELL

The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

(2009) Shin-ichiro Imai   CELL BIOCHEMISTRY AND BIOPHYSICS

Cardiac Na + Current Regulation by Pyridine Nucleotides

(2009) Man Liu et al.   CIRCULATION RESEARCH

Microbial NAD Metabolism: Lessons from Comparative Genomics

(2009) F. Gazzaniga et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Anticancer agent CHS-828 inhibits cellular synthesis of NAD

(2008) Uffe Høgh Olesen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD

(2008) Nathalie Busso et al.   PLoS One