SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions

(2016) Emil Carlsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways

(2015) Kannan Badri Narayanan et al.   APOPTOSIS

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons

(2015) Piyali Mukherjee et al.   JOURNAL OF IMMUNOLOGY

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons

(2015) Julie Vérièpe et al.   Nature Communications

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

(2014) Thomas Ve et al.   APOPTOSIS

Depletion of the Central Metabolite NAD Leads to Oncosis-mediated Cell Death

(2014) Christopher Del Nagro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

(2014) D. W. Summers et al.   JOURNAL OF NEUROSCIENCE

Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death

(2013) Piyali Mukherjee et al.   IMMUNITY

Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

(2013) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from theBrucellaProtein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

(2013) Greg A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

T-cell death following immune activation is mediated by mitochondria-localized SARM

(2012) P Panneerselvam et al.   CELL DEATH AND DIFFERENTIATION

Toll/Interleukin-1 Receptor Domain Dimers as the Platform for Activation and Enhanced Inhibition of Toll-like Receptor Signaling

(2012) Ota Fekonja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Control of Nonapoptotic Developmental Cell Death in Caenorhabditis elegans by a Polyglutamine-Repeat Protein

(2012) E. S. Blum et al.   SCIENCE

Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

(2011) Porkodi Panneerselvam et al.   BIOCHEMICAL JOURNAL

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Regulation of Anoxic Death in Caenorhabditis elegans by Mammalian Apoptosis Signal-Regulating Kinase (ASK) Family Proteins

(2011) T. Hayakawa et al.   GENETICS

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

(2011) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ectodomain of the Toll-like Receptor 4 Prevents Constitutive Receptor Activation

(2011) Gabriela Panter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Image-based Screening Identifies Novel Roles for IκB Kinase and Glycogen Synthase Kinase 3 in Axonal Degeneration

(2011) Josiah Gerdts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TIR domain-containing adaptor SARM is a late addition to the ongoing microbe–host dialog

(2010) Qing Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A Molecular Mechanism for Toll-IL-1 Receptor Domain-containing Adaptor Molecule-1-mediated IRF-3 Activation

(2010) Megumi Tatematsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY