High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance

(2018) I.A. Kourtzidis et al.   EXPERIMENTAL PHYSIOLOGY

NAD+ repletion produces no therapeutic effect in mice with respiratory chain complex III deficiency and chronic energy deprivation

(2018) Janne Purhonen et al.   FASEB JOURNAL

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet

(2017) Wenbiao Shi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

(2017) Jian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

(2017) Muheeb Beg et al.   eLife

Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation

(2017) Hung-Yao Ho et al.   Redox Biology

Obesity Is Associated With Low NAD+/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins

(2016) Sakari Jukarainen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The NAD+ precursor nicotinamide riboside decreases exercise performance in rats

(2016) Ioannis A. Kourtzidis et al.   Journal of the International Society of Sports Nutrition

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

NAMPT-Mediated NAD + Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

(2016) Kelly L. Stromsdorfer et al.   Cell Reports

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

(2016) Samuel A.J. Trammell et al.   Scientific Reports

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

(2014) James C. Lo et al.   CELL

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

(2014) Nahid A Khan et al.   EMBO Molecular Medicine

Assessment of Metabolic Flexibility of Old and Adult Mice Using Three Noninvasive, Indirect Calorimetry-Based Treatments

(2014) Loes P. M. Duivenvoorde et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A novel approach to monitor glucose metabolism using stable isotopically labelled glucose in longitudinal studies in mice

(2013) T H Van Dijk et al.   LABORATORY ANIMALS

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

TARGETED, LCMS-BASED METABOLOMICS FOR QUANTITATIVE MEASUREMENT OF NAD + METABOLITES

(2013) Samuel AJ Trammell et al.   Computational and Structural Biotechnology Journal

High circulating levels of S100A8/A9 complex (calprotectin) in male Japanese with abdominal adiposity and dysregulated expression of S100A8 and S100A9 in adipose tissues of obese mice

(2012) Ryohei Sekimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency

(2012) Eirini Meimaridou et al.   NATURE GENETICS

Recombinant Acylation Stimulating Protein Administration to C3−/− Mice Increases Insulin Resistance via Adipocyte Inflammatory Mechanisms

(2012) Mercedes Nancy Munkonda et al.   PLoS One

Dynamic Changes of Adiponectin and S100A8 Levels by the Selective Peroxisome Proliferator–Activated Receptor-γ Agonist Rivoglitazone

(2011) Aki Hiuge-Shimizu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Pellagra: a review with emphasis on photosensitivity

(2010) P. Wan et al.   BRITISH JOURNAL OF DERMATOLOGY

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice

(2010) Carrie A. Millward et al.   JOURNAL OF LIPID RESEARCH

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Challenging homeostasis to define biomarkers for nutrition related health

(2009) Ben van Ommen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metabolic flexibility and insulin resistance

(2008) Jose E. Galgani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

The secretory function of adipocytes in the physiology of white adipose tissue

(2008) Ping Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY