Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

(2012) Ilirjana Bajrami et al.   EMBO Molecular Medicine

Nicotinamide-induced Mitophagy

(2012) So-young Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Mitochondria of highly metastatic breast cancer cell line MDA-MB-231 exhibits increased autophagic properties

(2011) Yi-Fang Tu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

(2011) Robin Mathew et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Compartmentation of NAD+ -dependent signalling

(2011) Friedrich Koch-Nolte et al.   FEBS LETTERS

Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation

(2011) Lokendra Kumar Sharma et al.   HUMAN MOLECULAR GENETICS

Mitochondrial DNA mutations in respiratory complex-I in never-smoker lung cancer patients contribute to lung cancer progression and associated withEGFRgene mutation

(2011) Santanu Dasgupta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Heterogeneity in breast cancer

(2011) Kornelia Polyak   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial complex I deficiency of nuclear origin

(2011) Hélène Pagniez-Mammeri et al.   MOLECULAR GENETICS AND METABOLISM

Niacin requirements for genomic stability

(2011) James B. Kirkland   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Xenotransplantation of Mitochondrial Electron Transfer Enzyme, Ndi1, in Myocardial Reperfusion Injury

(2011) Cynthia N. Perry et al.   PLoS One

No Immune Responses by the Expression of the Yeast Ndi1 Protein in Rats

(2011) Mathieu Marella et al.   PLoS One

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Accumulation of mutations over the entire mitochondrial genome of breast cancer cells obtained by tissue microdissection

(2010) Liane Fendt et al.   BREAST CANCER RESEARCH AND TREATMENT

Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells

(2010) Mutsumi Yokota et al.   FEBS LETTERS

Evaluating mitochondrial DNA in patients with breast cancer and benign breast disease

(2010) Lijun Shen et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin B3, the nicotinamide adenine dinucleotides and aging

(2010) Ping Xu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional regulation of BRCA1 expression by a metabolic switch

(2010) Li-Jun Di et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1

(2010) Y Deng et al.   ONCOGENE

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

(2010) Hiyaa Singhee Ghosh et al.   PLoS One

Successful Amelioration of Mitochondrial Optic Neuropathy Using the Yeast NDI1 Gene in a Rat Animal Model

(2010) Mathieu Marella et al.   PLoS One

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction

(2010) A. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in human breast cancer cells and their transmitochondrial cybrids

(2009) Yewei Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

(2009) Alessandra Baracca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MDA-MB-435 and M14 Cell Lines: Identical but not M14 Melanoma?

(2009) Ann F. Chambers   CANCER RESEARCH

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Exogenous NAD Blocks Cardiac Hypertrophic Response via Activation of the SIRT3-LKB1-AMP-activated Kinase Pathway

(2009) Vinodkumar B. Pillai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognosis of Women With Metastatic Breast Cancer byHER2Status and Trastuzumab Treatment: An Institutional-Based Review

(2009) Shaheenah Dawood et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin

(2009) A. M. LeBeau et al.   MOLECULAR CANCER THERAPEUTICS

Neuroprotective Effect of Long-term NDI1 Gene Expression in a Chronic Mouse Model of Parkinson Disorder

(2009) Jennifer Barber-Singh et al.   REJUVENATION RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma

(2008) J. A. Mayr et al.   CLINICAL CANCER RESEARCH

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE