Role of SUMOylation in Neurodegenerative Diseases

Alzheimer’s Disease: An Update and Insights Into Pathophysiology

(2022) Murtala Bello Abubakar et al.   Frontiers in Aging Neuroscience

Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

(2022) Uri Nimrod Ramírez-Jarquín et al.   Science Advances

Regulation of Glucose, Fatty Acid and Amino Acid Metabolism by Ubiquitination and SUMOylation for Cancer Progression

(2022) Shunqin Zhu et al.   Frontiers in Cell and Developmental Biology

Effects of amyloid-β on protein SUMOylation and levels of mitochondrial proteins in primary cortical neurons

(2022) Ericks S. Soares et al.   IBRO Neuroscience Reports

Abeta-induced presynaptic release of UBC9 through extracellular vesicles involves SNAP23

(2022) Yan Long et al.   NEUROSCIENCE LETTERS

PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease

(2021) Eva L. Morozko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis

(2021) Marlon Yovera-Aldana et al.   PLoS One

Alzheimer disease

(2021) David S. Knopman et al.   Nature Reviews Disease Primers

Post-translational modifications: Regulators of neurodegenerative proteinopathies

(2021) Rohan Gupta et al.   AGEING RESEARCH REVIEWS

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism

(2021) Justyna Okarmus et al.   Stem Cell Reports

Post-translational Modifications of the Protein Termini

(2021) Li Chen et al.   Frontiers in Cell and Developmental Biology

Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein

(2021) André D. G. Leitão et al.   Communications Biology

Global Rhes knockout in the Q175 Huntington’s disease mouse model

(2021) Taneli Heikkinen et al.   PLoS One

PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3

(2021) Zixin Hou et al.   Cell Death Discovery

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

(2020) Arda B. Celen et al.   FEBS Journal

Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection

(2020) Ekta Singh et al.   MOLECULAR BIOLOGY REPORTS

Three-dimensional architecture of human diabetic peripheral nerves revealed by X-ray phase contrast holographic nanotomography

(2020) Lars B. Dahlin et al.   Scientific Reports

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

(2020) Larissa-Nele Schaffert et al.   Brain Sciences

SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes

(2020) Nitin Agarwal et al.   NEURON

Deciphering protein post-translational modifications using chemical biology tools

(2020) Anne C. Conibear   Nature Reviews Chemistry

Modification of Proteins by Metabolites in Immunity

(2020) C. Diskin et al.   IMMUNITY

Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

(2020) Zeinab Breijyeh et al.   MOLECULES

TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease

(2020) Guixin Zhu et al.   Cell Reports

Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

(2020) Briana R. De Miranda et al.   npj Parkinsons Disease

Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations

(2019) Brenden J. D. Hawk et al.   Frontiers in Neuroscience

Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy

(2019) Daniel Rangel Rojas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

(2019) Svitlana Yablonska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Parkinson’s Disease in Women and Men: What’s the Difference?

(2019) Silvia Cerri et al.   Journal of Parkinsons Disease

Diabetic neuropathy

(2019) Eva L. Feldman et al.   Nature Reviews Disease Primers

Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

(2019) David K. Simon et al.   CLINICS IN GERIATRIC MEDICINE

DJ-1 in Parkinson’s Disease: Clinical Insights and Therapeutic Perspectives

(2019) Mariaelena Repici et al.   Journal of Clinical Medicine

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

SUMOylation Prevents Huntingtin Fibrillization and Localization onto Lipid Membranes

(2019) Faezeh Sedighi et al.   ACS Chemical Neuroscience

The post-translational modification, SUMOylation, and cancer (Review)

(2018) Zhi-Jian Han et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Parkinson's disease: A review

(2018) Vinay Goyal et al.   NEUROLOGY INDIA

BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease

(2018) Jian Bao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control

(2018) Daniela Strobbe et al.   Frontiers in Molecular Neuroscience

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

Converging pathways in neurodegeneration, from genetics to mechanisms

(2018) Li Gan et al.   NATURE NEUROSCIENCE

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease

(2018) Ju Zheng et al.   Frontiers in Molecular Neuroscience

Advances in Parkinson’s Disease: 200 Years Later

(2018) Natalia López-González Del Rey et al.   Frontiers in Neuroanatomy

Metals and neurodegenerative diseases. A systematic review

(2017) Calogero Edoardo Cicero et al.   ENVIRONMENTAL RESEARCH

Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5

(2017) Ming-Ming Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen Modulates ubc9 Expression and Synaptic Redistribution in the Brain of APP/PS1 Mice and Cortical Neurons

(2017) Yu-Jie Lai et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

BCA2/Rabring7 Interferes with HIV-1 Proviral Transcription by Enhancing the SUMOylation of IκBα

(2017) Marta Colomer-Lluch et al.   JOURNAL OF VIROLOGY

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery

(2017) Dora Baczyk et al.   PLoS One

SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation

(2017) Ruth Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

Protein SUMOylation modification and its associations with disease

(2017) Yanfang Yang et al.   Open Biology

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress

(2016) Nicolas Stankovic‐Valentin et al.   EMBO JOURNAL

Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α

(2016) Daisuke Yamashita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Small GTP-Binding Protein Rhes Influences Nigrostriatal-Dependent Motor Behavior During Aging

(2016) Annalisa Pinna et al.   MOVEMENT DISORDERS

Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia

(2016) Alberto Brugnoli et al.   NEUROBIOLOGY OF DISEASE

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

(2016) Joseph Ochaba et al.   NEURON

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons

(2016) Leigh D Plant et al.   eLife

SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies

(2016) Ya-Chen Liang et al.   Scientific Reports

α-Synuclein is a Novel Microtubule Dynamase

(2016) Daniele Cartelli et al.   Scientific Reports

Extent of Inhibition of α-Synuclein Aggregation in Vitro by SUMOylation Is Conjugation Site- and SUMO Isoform-Selective

(2015) Tharindumala Abeywardana et al.   BIOCHEMISTRY

PIAS-like protein Zimp7 is required for the restriction of the zebrafish organizer and mesoderm development

(2015) Roberto Moreno-Ayala et al.   DEVELOPMENTAL BIOLOGY

Epidemiology of mild traumatic brain injury and neurodegenerative disease

(2015) Raquel C. Gardner et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

(2015) Jean-Hugues Guervilly et al.   MOLECULAR CELL

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly

(2015) Nathalie Eisenhardt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly

(2015) Nathalie Eisenhardt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMOylation: Novel Neuroprotective Approach for Alzheimer’s Disease?

(2015) Juliana B Hoppe et al.   Aging and Disease

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents

(2014) Greg M. Kowalski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission

(2014) P. Hemachandra Reddy   DRUG DISCOVERY TODAY

TIF1γ Protein Regulates Epithelial-Mesenchymal Transition by Operating as a Small Ubiquitin-like Modifier (SUMO) E3 Ligase for the Transcriptional Regulator SnoN1

(2014) Yoshiho Ikeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes

(2014) Che-Pei Kung et al.   MOLECULAR CANCER RESEARCH

Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination

(2014) Huanyu Qiao et al.   NATURE GENETICS

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease

(2014) Linda Lee et al.   Scientific Reports

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

UHRF2, a Ubiquitin E3 Ligase, Acts as a Small Ubiquitin-like Modifier E3 Ligase for Zinc Finger Protein 131

(2013) Yohan Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhes Deletion Is Neuroprotective in the 3-Nitropropionic Acid Model of Huntington's Disease

(2013) R. G. Mealer et al.   JOURNAL OF NEUROSCIENCE

Monetary Costs of Dementia in the United States

(2013) Michael D. Hurd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetic Neuropathy and Oxidative Stress: Therapeutic Perspectives

(2013) Asieh Hosseini et al.   Oxidative Medicine and Cellular Longevity

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

Lewy body pathology and typical Parkinson disease in a patient with a heterozygous (R275W) mutation in the Parkin gene (PARK2)

(2012) Claudio Ruffmann et al.   ACTA NEUROPATHOLOGICA

Ubiquitin-Like Proteins

(2012) Annemarthe G. van der Veen et al.   Annual Review of Biochemistry

Mechanistic insights into the regulation of metabolic enzymes by acetylation

(2012) Yue Xiong et al.   JOURNAL OF CELL BIOLOGY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Extensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint

(2012) Catherine A. Cremona et al.   MOLECULAR CELL

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Phosphorylation of Ubc9 by Cdk1 Enhances SUMOylation Activity

(2012) Yee-Fun Su et al.   PLoS One

NF-κB Repression by PIAS3 Mediated RelA SUMOylation

(2012) Yuangang Liu et al.   PLoS One

MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

(2011) Maren H. Stindt et al.   CELL CYCLE

The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators

(2011) Pablo García-Gutiérrez et al.   EMBO REPORTS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Sumoylation inhibits α-synuclein aggregation and toxicity

(2011) Petranka Krumova et al.   JOURNAL OF CELL BIOLOGY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Low Peripheral Nerve Conduction Velocities and Amplitudes Are Strongly Related to Diabetic Microvascular Complications in Type 1 Diabetes: The EURODIAB Prospective Complications Study

(2010) M. Charles et al.   DIABETES CARE

Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

(2010) J. Miller et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

(2010) Ivan Matic et al.   MOLECULAR CELL

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

SUMO E3 ligase activity of TRIM proteins

(2010) Y Chu et al.   ONCOGENE

The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

(2010) F. Pelisch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches

(2009) Douglas R. Langbehn et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

(2009) Emélie Braschi et al.   EMBO REPORTS

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Sumoylation of amyloid precursor protein negatively regulates Aβ aggregate levels

(2008) Yu-Qian Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A stress-dependent SUMO4 sumoylation of its substrate proteins

(2008) Wenzhong Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Disease: advanced glycation end-products and their receptor in inflammation and diabetes complications

(2008) Shi Fang Yan et al.   Nature clinical practice. Endocrinology & metabolism