Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain

Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice

(2021) Justyna Zareba-Paslawska et al.   Frontiers in Neurology

Patterns of neuronal Rhes as a novel hallmark of tauopathies

(2021) Alexander J. Ehrenberg et al.   ACTA NEUROPATHOLOGICA

Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography

(2021) Xuyuan Kuang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tunneling nanotubes: Reshaping connectivity

(2021) Chiara Zurzolo   CURRENT OPINION IN CELL BIOLOGY

Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomics

(2021) Peter McColgan et al.   HUMAN BRAIN MAPPING

An unusual presentation of Huntington’s disease

(2021) Martin Schulze Westhoff et al.   Clinical Case Reports

Prion-like properties of the mutant huntingtin protein in living organisms: the evidence and the relevance

(2021) Melanie Alpaugh et al.   MOLECULAR PSYCHIATRY

Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?

(2020) Srinivasa Subramaniam   BIOESSAYS

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Protein transmission in neurodegenerative disease

(2020) Chao Peng et al.   Nature Reviews Neurology

Investigating Tunneling Nanotubes in Cancer Cells: Guidelines for Structural and Functional Studies through Cell Imaging

(2020) Fatéméh Dubois et al.   Biomed Research International

Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

(2020) Kirby M Donnelly et al.   eLife

Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids

(2020) Giulia Pinto et al.   BIOCHEMICAL JOURNAL

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

(2019) Israel Hernandez et al.   Science Translational Medicine

Glutamate signaling at cytoneme synapses

(2019) Hai Huang et al.   SCIENCE

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion

(2019) Manish Sharma et al.   JOURNAL OF CELL BIOLOGY

Rhes, a striatal-enriched protein, promotes mitophagy via Nix

(2019) Manish Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses

(2019) Francesco Napolitano et al.   Scientific Reports

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

(2018) Elissa D. Pastuzyn et al.   CELL

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

(2018) James Ashley et al.   CELL

Tunneling Nanotubes: A Versatile Target for Cancer Therapy

(2018) Pragyaparamita Sahu et al.   CURRENT CANCER DRUG TARGETS

More expansive gene transfer to the rat CNS: AAV PHP.EB vector dose–response and comparison to AAV PHP.B

(2018) Robert D. Dayton et al.   GENE THERAPY

The Thyroid Hormone-target Gene Rhes a Novel Crossroad for Neurological and Psychiatric Disorders: New Insights from Animal Models

(2018) Francesco Napolitano et al.   NEUROSCIENCE

Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

(2018) Albert A. Davis et al.   Annual Review of Cell and Developmental Biology

Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum

(2017) Wei Wei et al.   JOURNAL OF NEUROPHYSIOLOGY

Striatal Distribution and Cytoarchitecture of Dopamine Receptor Subtype 1 and 2: Evidence from Double-Labeling Transgenic Mice

(2017) Keke Ren et al.   Frontiers in Neural Circuits

Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector

(2017) Ziqing Liu et al.   Scientific Reports

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain

(2016) U. Rüb et al.   BRAIN PATHOLOGY

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

The role of tau in the pathological process and clinical expression of Huntington’s disease

(2015) Romina Vuono et al.   BRAIN

Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington’s disease

(2015) Peter McColgan et al.   BRAIN

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

(2015) Supriya Swarnkar et al.   NEUROBIOLOGY OF DISEASE

Transcellular spreading of huntingtin aggregates in theDrosophilabrain

(2015) Daniel T. Babcock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain

(2015) Margaret M. P. Pearce et al.   Nature Communications

Mutant huntingtin is present in neuronal grafts in huntington disease patients

(2014) Francesca Cicchetti et al.   ANNALS OF NEUROLOGY

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

(2014) Eline Pecho-Vrieseling et al.   NATURE NEUROSCIENCE

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of D1 and D2 Dopamine Receptor Segregation in the Developing Striatum Using BAC Transgenic Mice

(2013) Dominic Thibault et al.   PLoS One

Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity

(2013) Guey-Ying Liao et al.   Molecular Metabolism

Intercellular organelle trafficking by membranous nanotube connections: a possible new role in cellular rejuvenation?

(2012) Yi Shan Lim et al.   CELL COMMUNICATION AND ADHESION

Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction

(2012) Yashar Seyed-Razavi et al.   IMMUNOLOGY AND CELL BIOLOGY

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice lacking rhes show altered morphine analgesia, tolerance, and dependence

(2010) Franklin A. Lee et al.   NEUROSCIENCE LETTERS

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Recurrent Collateral Connections of Striatal Medium Spiny Neurons Are Disrupted in Models of Parkinson's Disease

(2008) S. Taverna et al.   JOURNAL OF NEUROSCIENCE

Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol

(2008) J. Bertran-Gonzalez et al.   JOURNAL OF NEUROSCIENCE