Global Rhes knockout in the Q175 Huntington’s disease mouse model

RasGRP1 is a causal factor in the development of l-DOPA–induced dyskinesia in Parkinson’s disease

(2020) Mehdi Eshraghi et al.   Science Advances

Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice

(2020) Qiong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progression of basal ganglia pathology in heterozygous Q175 knock‐in Huntington's disease mice

(2020) Yunping Deng et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington’s disease

(2020) Taneli Heikkinen et al.   PLoS One

Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age

(2019) Giulia Costa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IKKβ slows Huntington’s disease progression in R6/1 mice

(2019) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice

(2019) Khaled S. Abd-Elrahman et al.   Molecular Brain

Rhes, a striatal-enriched protein, promotes mitophagy via Nix

(2019) Manish Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying autophagy using novel LC3B and p62 TR-FRET assays

(2018) Alberto Bresciani et al.   PLoS One

Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR

(2018) Thawfeek M. Varusai et al.   Scientific Reports

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age

(2018) Giulia Costa et al.   Frontiers in Aging Neuroscience

mTORC1 as the main gateway to autophagy

(2017) Yoana Rabanal-Ruiz et al.   Essays in Biochemistry

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

(2016) Mitchell S. Wold et al.   Molecular Neurodegeneration

Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia

(2016) Alberto Brugnoli et al.   NEUROBIOLOGY OF DISEASE

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

(2016) Joseph Ochaba et al.   NEURON

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

(2015) Supriya Swarnkar et al.   NEUROBIOLOGY OF DISEASE

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion

(2015) Veronica Ghiglieri et al.   Scientific Reports

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins

(2014) Douglas Macdonald et al.   PLoS One

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

Rheb and Rags come together at the lysosome to activate mTORC1: Figure 1

(2013) Marlous J. Groenewoud et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

(2013) Boxun Lu et al.   FASEB JOURNAL

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhes Deletion Is Neuroprotective in the 3-Nitropropionic Acid Model of Huntington's Disease

(2013) R. G. Mealer et al.   JOURNAL OF NEUROSCIENCE

Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum

(2013) L.M. Harrison et al.   NEUROSCIENCE

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease

(2013) Brandon A. Baiamonte et al.   PLoS One

Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction

(2013) Barbara Baldo et al.   PLoS One

Golgi Protein ACBD3 Mediates Neurotoxicity Associated with Huntington’s Disease

(2013) Juan I. Sbodio et al.   Cell Reports

Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

(2013) Stephen R Daley et al.   eLife

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

TR-FRET-Based Duplex Immunoassay Reveals an Inverse Correlation of Soluble and Aggregated Mutant huntingtin in Huntington's Disease

(2012) Barbara Baldo et al.   CHEMISTRY & BIOLOGY

Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease

(2012) Nicole M. Lewandowski et al.   NEUROBIOLOGY OF DISEASE

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

(2012) Taneli Heikkinen et al.   PLoS One

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

(2011) Tamara Seredenina et al.   PLoS One

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Early autophagic response in a novel knock-in model of Huntington disease

(2010) Mary Y. Heng et al.   HUMAN MOLECULAR GENETICS

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

(2010) Jonathan H Fox et al.   Molecular Neurodegeneration

Huntington’s Disease is a disorder of the corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum)

(2010) Srinivasa Subramaniam et al.   NEUROPHARMACOLOGY

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

(2010) Shuqiu Zheng et al.   PLoS Genetics

Single-step detection of mutant huntingtin in animal and human tissues: A bioassay for Huntington’s disease

(2009) Andreas Weiss et al.   ANALYTICAL BIOCHEMISTRY

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice

(2008) M.A. Hickey et al.   NEUROSCIENCE