PIAS1 alleviates diabetic peripheral neuropathy through SUMOlation of PPAR-γ and miR-124-induced downregulation of EZH2/STAT3

Schwann cells apoptosis is induced by high glucose in diabetic peripheral neuropathy

(2020) Yu-pu Liu et al.   LIFE SCIENCES

The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials)

(2020) Seyedeh Hoda Seyedizadeh et al.   Journal of Diabetes Research

Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation

(2020) Yu-Chi Cheng et al.   Cells

STAT3 phosphorylation mediates high glucose–impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy

(2019) Wei Du et al.   FASEB JOURNAL

Sumoylation of PPARγ contributes to vascular endothelium insulin resistance through stabilizing the PPARγ–NcoR complex

(2019) Dongyi Lan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR‐124a enhances therapeutic effects of bone marrow stromal cells transplant on diabetic nephropathy‐related epithelial‐to‐mesenchymal transition and fibrosis

(2019) Xiaojun Cai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Increases in miR-124-3p in Microglial Exosomes Confer Neuroprotective Effects by Targeting FIP200-Mediated Neuronal Autophagy Following Traumatic Brain Injury

(2019) Dai Li et al.   NEUROCHEMICAL RESEARCH

Huangqi Guizhi Wuwu decoction for diabetic peripheral neuropathy

(2019) Yuan Zhang et al.   MEDICINE

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma

(2019) Jong Hyun Lee et al.   Biomolecules

miR-124 ameliorates depressive-like behavior by targeting STAT3 to regulate microglial activation

(2019) Danning Lou et al.   MOLECULAR AND CELLULAR PROBES

MiR-124 induces autophagy-related cell death in cholangiocarcinoma cells through direct targeting of the EZH2–STAT3 signaling axis

(2018) Jun Ma et al.   EXPERIMENTAL CELL RESEARCH

IRE1α siRNA relieves endoplasmic reticulum stress-induced apoptosis and alleviates diabetic peripheral neuropathy in vivo and in vitro

(2018) Weijie Yao et al.   Scientific Reports

LncRNA LINC00968 accelerates the proliferation and fibrosis of diabetic nephropathy by epigenetically repressing p21 via recruiting EZH2

(2018) Zhenjin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pregabalin and lacosamide ameliorate paclitaxel-induced peripheral neuropathy via inhibition of JAK/STAT signaling pathway and Notch-1 receptor

(2018) Khaled F. Al-Massri et al.   NEUROCHEMISTRY INTERNATIONAL

Intrathecal circHIPK3 shRNA alleviates neuropathic pain in diabetic rats

(2018) Liang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation

(2018) Bo Xie et al.   BMC CELL BIOLOGY

miR-124-3p attenuates neuropathic pain induced by chronic sciatic nerve injury in rats via targeting EZH2

(2018) Yang Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy

(2018) You Chul Chung et al.   Cell Death & Disease

Activation of PPARγ inhibits HDAC1-mediated pulmonary arterial smooth muscle cell proliferation and its potential mechanisms

(2017) Fangwei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

WT1 ameliorates podocyte injury via repression of EZH2/β-catenin pathway in diabetic nephropathy

(2017) Jiao Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Peripheral Myelination through Transcriptional Buffering of Egr2 by an Antisense Long Non-coding RNA

(2017) Margot Martinez-Moreno et al.   Cell Reports

Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue

(2015) Yang Liu et al.   DIABETES

Therapeutic Effects of Fenofibrate on Diabetic Peripheral Neuropathy by Improving Endothelial and Neural Survival in db/db Mice

(2014) Ye Rim Cho et al.   PLoS One

CD8+T Cell-Mediated Cytotoxicity toward Schwann Cells Promotes Diabetic Peripheral Neuropathy

(2013) Wei Tang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Glucose-Induced Metabolic Memory in Schwann Cells: Prevention by PPAR Agonists

(2013) Esther S. Kim et al.   ENDOCRINOLOGY

Protein Inhibitor of Activated STAT 1 (PIAS1) Is Identified as the SUMO E3 Ligase of CCAAT/Enhancer-Binding Protein β (C/EBPβ) during Adipogenesis

(2013) Yang Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Advances in the epidemiology, pathogenesis and management of diabetic peripheral neuropathy

(2012) Solomon Tesfaye et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Diabetic Peripheral Neuropathy and the Management of Diabetic Peripheral Neuropathic Pain

(2012) Sarkis Morales-Vidal et al.   POSTGRADUATE MEDICINE

Changes of Peroxisome Proliferator-Activated Receptor-γ on Crushed Rat Sciatic Nerves and Differentiated Primary Schwann Cells

(2011) Yi Cao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Automatic analysis of diabetic peripheral neuropathy using multi-scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging

(2011) M.A. Dabbah et al.   MEDICAL IMAGE ANALYSIS

Peroxisome proliferator-activated receptor gamma (PPARγ): Is the genomic activity the only answer?

(2009) Michaela Luconi et al.   STEROIDS