A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly

Precise gene deletion and replacement using the CRISPR/Cas9 system in human cells

(2016) Qiupeng Zheng et al.   BIOTECHNIQUES

Alternative splicing and co-option of transposable elements: the case of TMPO/LAP2α and ZNF451 in mammals

(2015) Federico Abascal et al.   BIOINFORMATICS

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

(2015) Jean-Hugues Guervilly et al.   MOLECULAR CELL

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

(2015) Ian Gibbs-Seymour et al.   MOLECULAR CELL

Noncovalent Interactions with SUMO and Ubiquitin Orchestrate Distinct Functions of the SLX4 Complex in Genome Maintenance

(2015) Jian Ouyang et al.   MOLECULAR CELL

SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development

(2014) L. Wang et al.   EMBO REPORTS

SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss

(2014) Kouji Hirota et al.   GENES TO CELLS

Ubiquitin Chain Elongation Requires E3-Dependent Tracking of the Emerging Conjugate

(2014) Aileen Kelly et al.   MOLECULAR CELL

Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly

(2014) Nicholas G. Brown et al.   MOLECULAR CELL

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteome-Wide Identification of SUMO2 Modification Sites

(2014) T. Tammsalu et al.   Science Signaling

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Decoding the SUMO signal

(2013) Ronald T. Hay   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of a Non-covalent Ternary Complex Formed by PIAS1, SUMO1, and UBC9 Proteins Involved in Transcriptional Regulation

(2013) Xavier H. Mascle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

(2013) Sara L. Poulsen et al.   JOURNAL OF CELL BIOLOGY

Targeted Identification of SUMOylation Sites in Human Proteins Using Affinity Enrichment and Paralog-specific Reporter Ions

(2013) Frederic Lamoliatte et al.   MOLECULAR & CELLULAR PROTEOMICS

Ubc9 Sumoylation Controls SUMO Chain Formation and Meiotic Synapsis in Saccharomyces cerevisiae

(2013) Helene Klug et al.   MOLECULAR CELL

Detecting endogenous SUMO targets in mammalian cells and tissues

(2013) Janina Becker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMO Rules: Regulatory Concepts and Their Implication in Neurologic Functions

(2013) Mathias Droescher et al.   NEUROMOLECULAR MEDICINE

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

The RanBP2/RanGAP1∗SUMO1/Ubc9 Complex Is a Multisubunit SUMO E3 Ligase

(2012) Andreas Werner et al.   MOLECULAR CELL

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs

(2012) Philip Knuckles et al.   NATURE NEUROSCIENCE

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

(2012) C. M. Guzzo et al.   Science Signaling

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1

(2011) S. Hofmann et al.   EUROPEAN RESPIRATORY JOURNAL

Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis

(2011) Andrew T. Namanja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

(2011) M. H. Tatham et al.   Science Signaling

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

PIAS proteins: pleiotropic interactors associated with SUMO

(2009) Miia M. Rytinki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure of the Siz/PIAS SUMO E3 Ligase Siz1 and Determinants Required for SUMO Modification of PCNA

(2009) Ali A. Yunus et al.   MOLECULAR CELL

ZNF451 Is a Novel PML Body- and SUMO-Associated Transcriptional Coregulator

(2008) Ulla Karvonen et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubc9 Sumoylation Regulates SUMO Target Discrimination

(2008) Puck Knipscheer et al.   MOLECULAR CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY