The KEAP1-NRF2 System and Esophageal Cancer

High expression of nuclear NRF2 combined with NFE2L2 alterations predicts poor prognosis in esophageal squamous cell carcinoma patients

(2022) Xingran Jiang et al.   MODERN PATHOLOGY

Correlation between TXNRD1/HO-1 expression and response to neoadjuvant chemoradiation therapy in patients with esophageal squamous cell carcinoma

(2022) Ryujiro Akaishi et al.   Esophagus

Halofuginone micelle nanoparticles eradicate Nrf2-activated lung adenocarcinoma without systemic toxicity

(2022) Harit Panda et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Double-Edged Sword of Oxidative Stress in Skin Damage and Melanoma: From Physiopathology to Therapeutical Approaches

(2022) Monica Emanuelli et al.   Antioxidants

The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo

(2022) Ayumi Kuga et al.   MOLECULAR AND CELLULAR BIOLOGY

Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway

(2022) Giovanni Tossetta et al.   PHARMACOLOGICAL RESEARCH

Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium

(2022) Wataru Hirose et al.   Cellular and Molecular Gastroenterology and Hepatology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution

(2021) Georg A. Busslinger et al.   Cell Reports

The antioxidant response in Barrett's tumorigenesis: A double-edged sword

(2021) Dunfa Peng et al.   Redox Biology

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

(2021) Yuta Horie et al.   Communications Biology

Stem cells and origins of cancer in the upper gastrointestinal tract

(2021) Yoku Hayakawa et al.   Cell Stem Cell

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

(2021) Lei Feng et al.   Journal of Translational Medicine

Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells

(2021) Kannappan Sriramajayam et al.   Redox Biology

Development of targeted therapy of NRF2high esophageal squamous cell carcinoma

(2021) Chorlada Paiboonrungruang et al.   CELLULAR SIGNALLING

Mutant clones in normal epithelium outcompete and eliminate emerging tumours

(2021) B. Colom et al.   NATURE

Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma

(2020) Yongping Cui et al.   CELL RESEARCH

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium

(2020) Bartomeu Colom et al.   NATURE GENETICS

A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice

(2020) Gabriel Piedrafita et al.   Nature Communications

NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma

(2020) Joab Otieno Odera et al.   BIOCHEMICAL JOURNAL

Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors

(2020) Makiko Hayashi et al.   CANCER RESEARCH

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation

(2020) Meiling Gong et al.   Cell Communication and Signaling

Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy

(2020) Di Xia et al.   Cell and Bioscience

A Phase 1 Trial of MLN0128 (sapanisertib) and CB-839 HCl (telaglenastat) in Advanced NSCLC Patients (NCI 10327): Rationale and Study Design

(2020) Jonathan W. Riess et al.   Clinical Lung Cancer

Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium

(2020) Ewa Szczesny-Malysiak et al.   Oxidative Medicine and Cellular Longevity

Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium

(2020) Makoto Horiuchi et al.   MOLECULAR AND CELLULAR BIOLOGY

Polygalacin D suppresses esophageal squamous cell carcinoma growth and metastasis through regulating miR-142-5p/Nrf2 axis

(2020) Shuao Xiao et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 Activation in Cancer: From DNA to Protein

(2019) Erica W. Cloer et al.   CANCER RESEARCH

Stem cell competition orchestrates skin homeostasis and ageing

(2019) Nan Liu et al.   NATURE

Involvement of the PI3K/Akt/Nrf2 Signaling Pathway in Resveratrol-Mediated Reversal of Drug Resistance in HL-60/ADR Cells

(2019) Yongjun Li et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

(2019) David Fernandez-Antoran et al.   Cell Stem Cell

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

The expression of p‐p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance

(2019) Zhe Wang et al.   Thoracic Cancer

Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target

(2018) Shaohua Ma et al.   Annals of the New York Academy of Sciences

The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma

(2018) Milica Momcilovic et al.   CANCER CELL

Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients

(2018) De-Chen Lin et al.   GASTROENTEROLOGY

Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species

(2018) Yuki Kitano et al.   JOURNAL OF PATHOLOGY

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy

(2018) Jingze Zhang et al.   Thoracic Cancer

Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

(2018) Kasumi Murai et al.   Cell Stem Cell

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

A catalogue of somatic NRF2 gain-of-function mutations in cancer

(2018) Michael John Kerins et al.   Scientific Reports

Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus

(2018) Junsheng Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation

(2017) Kouhei Tsuchida et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration

(2017) Véronique Giroux et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1

(2017) Burak Akdemir et al.   MOLECULAR CANCER RESEARCH

Integrated genomic characterization of oesophageal carcinoma

(2017)   NATURE

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

Spontaneous recombinase activity of Cre–ERT2 in vivo

(2017) Jasmin Kristianto et al.   TRANSGENIC RESEARCH

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane

(2017) Albena T. Dinkova-Kostova et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus

(2017) Takafumi Suzuki et al.   Nature Communications

Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations

(2017) Jiang Chang et al.   Nature Communications

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma

(2017) Federico Pio Fabrizio et al.   Oncotarget

WDR23 regulates NRF2 independently of KEAP1

(2017) Jacqueline Y. Lo et al.   PLoS Genetics

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Genomic Characterization of Esophageal Squamous Cell Carcinoma Reveals Critical Genes Underlying Tumorigenesis and Poor Prognosis

(2016) Hai-De Qin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

(2016) H. Satoh et al.   CANCER RESEARCH

Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection

(2016) Akihito Otsuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population

(2016) Genta Sawada et al.   GASTROENTEROLOGY

A single dividing cell population with imbalanced fate drives oesophageal tumour growth

(2016) Julia Frede et al.   NATURE CELL BIOLOGY

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma

(2016) Jia-Jie Hao et al.   NATURE GENETICS

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

(2016) Leonard D. Goldstein et al.   Cell Reports

BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis

(2015) Ming Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

(2015) Ryota Saito et al.   MOLECULAR AND CELLULAR BIOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

(2015) Tatsuhiro Shibata et al.   NEOPLASIA

Nrf2 is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma

(2014) Yota Kawasaki et al.   ANNALS OF SURGICAL ONCOLOGY

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Identification of genomic alterations in oesophageal squamous cell cancer

(2014) Yongmei Song et al.   NATURE

Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

(2014) Maria P. Alcolea et al.   NATURE CELL BIOLOGY

Genetic landscape of esophageal squamous cell carcinoma

(2014) Yi-Bo Gao et al.   NATURE GENETICS

Genomic and molecular characterization of esophageal squamous cell carcinoma

(2014) De-Chen Lin et al.   NATURE GENETICS

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular Heterogeneity in the Mouse Esophagus Implicates the Presence of a Nonquiescent Epithelial Stem Cell Population

(2014) Aaron D. DeWard et al.   Cell Reports

CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

(2013) A. Ooi et al.   CANCER RESEARCH

A Phase I Study of the HSP90 Inhibitor Retaspimycin Hydrochloride (IPI-504) in Patients with Gastrointestinal Stromal Tumors or Soft-Tissue Sarcomas

(2013) A. J. Wagner et al.   CLINICAL CANCER RESEARCH

Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium

(2013) Hao Chen et al.   GUT

Nrf2 Enhances Cholangiocyte Expansion in Pten-Deficient Livers

(2013) Keiko Taguchi et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

(2013) Toshiaki Fukutomi et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels

(2013) T. Suzuki et al.   MOLECULAR AND CELLULAR BIOLOGY

The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors

(2013) Shinsuke Yamamoto et al.   MOLECULAR CANCER RESEARCH

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

(2013) Russell R. A. Kitson et al.   Nature Chemistry

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

(2013) Austin M Dulak et al.   NATURE GENETICS

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Gastro-esophageal reflux disease and obesity, where is the link?

(2013) Sara Emerenziani   WORLD JOURNAL OF GASTROENTEROLOGY

Roles of Keap1-Nrf2 System in Upper Aerodigestive Tract Carcinogenesis

(2012) A. Ohkoshi et al.   Cancer Prevention Research

A global assessment of the oesophageal adenocarcinoma epidemic

(2012) Gustaf Edgren et al.   GUT

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

(2012) Tracy L Keller et al.   Nature Chemical Biology

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Transcript Profiling Identifies Dynamic Gene Expression Patterns and an Important Role for Nrf2/Keap1 Pathway in the Developing Mouse Esophagus

(2012) Hao Chen et al.   PLoS One

A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium

(2012) D. P. Doupe et al.   SCIENCE

Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource

(2012) Caleb S. Heffner et al.   Nature Communications

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Select Heterozygous Keap1 Mutations Have a Dominant-Negative Effect on Wild-Type Keap1 In Vivo

(2010) T. Suzuki et al.   CANCER RESEARCH

Phase II AIDS Malignancy Consortium Trial of Topical Halofuginone in AIDS-Related Kaposi Sarcoma

(2010) Henry B Koon et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

(2010) K. Taguchi et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Deletion ofKeap1in the Lung Attenuates Acute Cigarette Smoke–Induced Oxidative Stress and Inflammation

(2009) David J. Blake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

(2008) Rui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY