Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells

In Barrett’s epithelial cells, weakly acidic bile salt solutions cause oxidative DNA damage with response and repair mediated by p38

(2020) Xiaofang Huo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Trends in the incidence and survival of patients with esophageal cancer: A SEER database analysis

(2020) Haiqi He et al.   Thoracic Cancer

Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage

(2019) Zhangjian Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells

(2019) Dunfa Peng et al.   CANCER LETTERS

APE1 upregulates MMP-14 via redox-sensitive ARF6-mediated recycling to promote cell invasion of esophageal adenocarcinoma

(2019) Heng Lu et al.   CANCER RESEARCH

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Oxidative Stress and Cancer: The Role of Nrf2

(2018) Soraya Sajadimajd et al.   CURRENT CANCER DRUG TARGETS

Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1

(2018) Ajaz A. Bhat et al.   ONCOGENE

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Activation of NADPH oxidases leads to DNA damage in esophageal cells

(2017) Vikas Bhardwaj et al.   Scientific Reports

The epidemic of oesophageal carcinoma: Where are we now?

(2016) Aaron P. Thrift   Cancer Epidemiology

From Reflux Esophagitis to Esophageal Adenocarcinoma

(2016) Rhonda F. Souza   DIGESTIVE DISEASES

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

(2016) Hui Wang et al.   Science Translational Medicine

APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts

(2016) Jun Hong et al.   Oncotarget

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

APE1 promotes antioxidant capacity by regulating Nrf-2 function through a redox-dependent mechanism

(2015) Jin-Lu Shan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

From reflux esophagitis to Barrett’s esophagus and esophageal adenocarcinoma

(2015) Rui-Hua Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2

(2014) Melissa L. Fishel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activin A balance regulates epithelial invasiveness and tumorigenesis

(2014) Grégoire F Le Bras et al.   LABORATORY INVESTIGATION

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis

(2014) Dun-Fa Peng et al.   Journal of Cancer

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Investigating cervical, oesophageal and colon cancer risk and survival among migrants in The Netherlands

(2012) M. Arnold et al.   EUROPEAN JOURNAL OF PUBLIC HEALTH

Development of Subsquamous High-Grade Dysplasia and Adenocarcinoma After Successful Radiofrequency Ablation of Barrett's Esophagus

(2012) Mohammad Titi et al.   GASTROENTEROLOGY

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells

(2011) DunFa Peng et al.   GUT

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

(2011) Carlo Vascotto et al.   MOLECULAR BIOLOGY OF THE CELL

Production and Detection of Reactive Oxygen Species (ROS) in Cancers

(2011) Danli Wu et al.   Jove-Journal of Visualized Experiments

Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1

(2010) Mark R. Kelley et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Epidemiology of esophageal cancer: Orient to Occident. Effects of chronology, geography and ethnicity

(2009) Michio Hongo et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

(2009) Yoo Ri Kim et al.   JOURNAL OF PATHOLOGY

Transcriptional Regulatory Functions of Mammalian AP-Endonuclease (APE1/Ref-1), an Essential Multifunctional Protein

(2008) Kishor K. Bhakat et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

(2008) Tatsuhiro Shibata et al.   GASTROENTEROLOGY

DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma

(2008) D F Peng et al.   GUT