Mutant clones in normal epithelium outcompete and eliminate emerging tumours

A role for keratin 17 during DNA damage response and tumor initiation

(2021) Raji R. Nair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tobacco smoking and somatic mutations in human bronchial epithelium

(2020) Kenichi Yoshida et al.   NATURE

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

The mutational landscape of normal human endometrial epithelium

(2020) Luiza Moore et al.   NATURE

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium

(2020) Bartomeu Colom et al.   NATURE GENETICS

A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice

(2020) Gabriel Piedrafita et al.   Nature Communications

Extensive heterogeneity in somatic mutation and selection in the human bladder

(2020) Andrew R. J. Lawson et al.   SCIENCE

Selection of oncogenic mutant clones in normal human skin varies with body site

(2020) Joanna C Fowler et al.   Cancer Discovery

Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing

(2020) Peter Ellis et al.   Nature Protocols

Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

(2019) David Fernandez-Antoran et al.   Cell Stem Cell

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

Keratin 17 activates AKT signalling and induces epithelial-mesenchymal transition in oesophageal squamous cell carcinoma

(2019) Zhun Liu et al.   Journal of Proteomics

pyABC: distributed, likelihood-free inference

(2018) Emmanuel Klinger et al.   BIOINFORMATICS

Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

(2018) Kasumi Murai et al.   Cell Stem Cell

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

(2018) Kazuaki Suda et al.   Cell Reports

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Correction of aberrant growth preserves tissue homeostasis

(2017) Samara Brown et al.   NATURE

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

(2017) Shunsuke Kon et al.   NATURE CELL BIOLOGY

A single dividing cell population with imbalanced fate drives oesophageal tumour growth

(2016) Julia Frede et al.   NATURE CELL BIOLOGY

Constrained positive selection on cancer mutations in normal skin

(2016) Iñigo Martincorena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of a DEN-induced mouse model of esophageal squamous cell carcinoma metastasis

(2016) Kazuo Narushima et al.   Esophagus

Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes

(2015) Ryan P Hobbs et al.   NATURE GENETICS

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

CopywriteR: DNA copy number detection from off-target sequence data

(2015) Thomas Kuilman et al.   GENOME BIOLOGY

Subclonal variant calling with multiple samples and prior knowledge

(2014) M. Gerstung et al.   BIOINFORMATICS

DNA copy number analysis of fresh and formalin-fixed specimens by shallow whole-genome sequencing with identification and exclusion of problematic regions in the genome assembly

(2014) Ilari Scheinin et al.   GENOME RESEARCH

Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

(2014) Maria P. Alcolea et al.   NATURE CELL BIOLOGY

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

(2013) L. Vermeulen et al.   SCIENCE

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium

(2012) D. P. Doupe et al.   SCIENCE

Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems

(2008) T. Toni et al.   Journal of the Royal Society Interface