Article
Surgery
Zehao Huang, Xiwei Zhang, Ye Zhang, Huizhu Cai, Shixu Wang, Lingdun Zhuge, Changming An, Zhengjiang Li
Summary: The study compared the efficacy of CCRT and SRT in patients with stage III/IV HPSCC, finding that SRT significantly outperformed CCRT in terms of overall survival and disease-free survival, especially for N2-N3 stage patients.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Hua Su, Fei Yang, Rao Fu, Xin Li, Randall French, Evangeline Mose, Xiaohong Pu, Brittney Trinh, Avi Kumar, Junlai Liu, Laura Antonucci, Jelena Todoric, Yuan Liu, Yinling Hu, Maria T. Diaz-Meco, Jorge Moscat, Christian M. Metallo, Andrew M. Lowy, Beicheng Sun, Michael Karin
Summary: Although many cancers rely on autophagy for nutrient acquisition, blocking autophagy alone does not effectively inhibit tumor growth. Research has shown that blocking autophagy can lead to pancreatic ductal adenocarcinoma (PDAC) upregulating an alternative nutrient pathway, macropinocytosis (MP), allowing tumor cells to extract nutrients from outside sources. This switch from autophagy to MP, driven by the activation of transcription factor NRF2, presents a potential therapeutic strategy for inhibiting tumor growth and regression.
Article
Oncology
Wolfgang Schroeder, Markus P. H. Ghadimi, Hans Schloesser, Heike Loeser, Petra Schiller, Thomas Zander, Florian Gebauer, Hans Fuchs, Alexander Quaas, Christiane J. Bruns
Summary: This study analyzed the long-term survival and recurrence patterns after pathological complete response (pCR) with and without nodal metastases following multimodal treatment of esophageal cancer. Results showed that patients without nodal metastases had higher 5-year overall survival compared to patients with metastatic nodes. The presence of nodal metastases predicted both locoregional and distant recurrence. Follow-up recommendations should take into account the presence or absence of nodal metastases in patients with pCR, and caution should be exercised when considering watch-and-wait surveillance strategies for suspected clinical complete response.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yuta Ogura, Kazuki Terashima, Yoshihide Nanno, SungChul Park, Masaki Suga, Daiki Takahashi, Yoshiro Matsuo, Nor Shazrina Sulaiman, Sunao Tokumaru, Tomoaki Okimoto, Hirochika Toyama, Takumi Fukumoto
Summary: GPT is a promising treatment option for patients with LAPC at the pancreatic body-tail and those with LAPC without anterior peripancreatic invasion. Pancreatic body-tail LAPC patients had higher irradiated dose to the gross tumor volume, while LAPC patients with anterior peripancreatic invasion had a higher rate of peritoneal recurrence within 6 months after GPT.
RADIATION ONCOLOGY
(2022)
Article
Surgery
Ying-Jian Wang, Tao Bao, Kun-Kun Li, Xian-Feng Xie, Xian-Dong He, Xiao-Long Zhao, Wei Guo
Summary: This study evaluated the effectiveness of concurrent radiotherapy in esophageal cancer patients receiving neoadjuvant therapy. A retrospective analysis was conducted on 1026 patients who underwent minimally invasive esophagectomy. The results showed that neoadjuvant chemotherapy had advantages in terms of shorter operation time, less blood loss, and higher number of lymph nodes retrieved compared to neoadjuvant chemoradiotherapy, without compromising the surgical outcomes and long-term survival.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Christopher A. Latz, Srihari Lella, Laura T. Boitano, Charles DeCarlo, Zach Feldman, C. Y. Maximilian Png, Jahan Mohebali, Anahita Dua, Mark Conrad
Summary: The study found that performing splenectomy during open TAAA repair did not result in increased perioperative mortality, but did lead to significantly higher perioperative morbidity and longer hospital stays. Results showed that splenectomy did not have an impact on long-term survival outcomes for patients undergoing TAAA repair.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Oncology
Somnath Mukherjee, Christopher Hurt, Ganesh Radhakrishna, Sarah Gwynne, Andrew Bateman, Simon Gollins, Maria A. Hawkins, Joanne Canham, Heike I. Grabsch, Stephen Falk, Ricky A. Sharma, Ruby Ray, Rajarshi Roy, Catrin Cox, Nick Maynard, Lisette Nixon, David J. Sebag-Montefiore, Timothy Maughan, Gareth O. Griffiths, Tom D. L. Crosby
Summary: This study evaluated two neoadjuvant chemoradiotherapy regimens for localised oesophageal adenocarcinoma or gastro-oesophageal junction adenocarcinoma, showing that CarPacRT had better survival outcomes and progression patterns compared to OxCapRT. Distant progression was more common than locoregional progression in both regimens, suggesting a need to prioritize systemic treatment optimization.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Alessia Garufi, Eugenia Giorno, Maria Saveria Gilardini Montani, Giuseppa Pistritto, Alessandra Crispini, Mara Cirone, Gabriella D'Orazi
Summary: The study found that the zinc-curcumin compound can activate NRF2 and decrease the levels of Keap1, increasing cancer cell sensitivity to Zn(II)-curc-induced cell death. The crosstalk between p62/SQSTM1 and NRF2 could be therapeutically exploited to enhance cancer patient response to therapies.
Article
Biochemistry & Molecular Biology
Qian Zeng, Tingting Zhou, Feiyan Zhao, Dayan Xiong, Bin He, Qingzhong Hua, Miao Lin, Lang Deng, Xiaoxue Sang, Weixi Xie, Jia Chen, Zun Wang, Lu Ren, Ziqiang Luo, Xiaoting Huang, Wei Liu, Siyuan Tang
Summary: Bergenin can alleviate pulmonary fibrosis by relieving oxidative stress, reducing extracellular matrix deposition, and inhibiting the formation of myofibroblasts. Furthermore, a regulatory loop between p62 and Nrf2 is formed, which is important for the therapeutic effects of bergenin on pulmonary fibrosis.
Article
Oncology
Xin Hua, Wang-Zhong Li, Xin Huang, Wen Wen, Han-Ying Huang, Zhi-Qing Long, Huan-Xin Lin, Zhong-Yu Yuan, Ling Guo
Summary: The study aimed to construct a prognostic nomogram including Sarcopenia and EBV-DNA for NPC patients receiving CCRT, which resulted in more accurate prediction of prognosis. The research showed that using the S-E grade for predicting overall survival was more accurate than using TNM staging and sarcopenia or EBV-DNA alone.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tiing Yee Siow, Chih-Hua Yeh, Gigin Lin, Chien-Yu Lin, Hung-Ming Wang, Chun-Ta Liao, Cheng-Hong Toh, Sheng-Chieh Chan, Ching-Po Lin, Shu-Hang Ng
Summary: The study found that using MRI radiomic models combined with traditional clinical parameters can more accurately predict the survival rate of patients with hypopharyngeal cancer who undergo concurrent chemoradiotherapy. This research is important for informing tailored management strategies.
Article
Biochemistry & Molecular Biology
Shu-Man Hsieh Li, Shu-Ting Liu, Yung-Lung Chang, Gunng-Shinng Chen, Shih-Ming Huang
Summary: In this study, the researchers investigated the crosstalk between myogenin and Nrf2/p62 in muscle cells. They identified several potential drugs that can regulate the expression of myogenin, providing a deeper understanding of the mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Zhuochen Cai, Dongni Chen, Wenze Qiu, Chixiong Liang, Yingying Huang, Jiayu Zhou, Zejiang Zhan, Yanqun Xiang, Xiang Guo, Xing Lv
Summary: Adding nimotuzumab to concurrent chemoradiotherapy shows favorable clinical outcomes in patients with stage III-IVa nasopharyngeal carcinoma, with good tolerance and similar toxicity compared to CCRT alone.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Kosei Doshita, Hirotsugu Kenmotsu, Shota Omori, Yuya Tabuchi, Takanori Kawabata, Hiroaki Kodama, Naoya Nishioka, Eriko Miyawaki, Yuko Iida, Taichi Miyawaki, Nobuaki Mamesaya, Haruki Kobayashi, Ryo Ko, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Keita Mori, Hideyuki Harada, Takeshi Kaneko, Toshiaki Takahashi
Summary: Data from a retrospective study of 120 patients with limited disease small cell lung cancer (LD-SCLC) receiving concurrent chemoradiotherapy (CCRT) showed an improvement in the long-term survival rate, with no identified prognostic factors associated with long-term prognosis.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Oncology
Mia Johansson, Anna Axelsson, Eva Haglind, David Bock, Eva Angenete
Summary: This study analyzed the long-term oncological outcomes of anal cancer patients in Sweden diagnosed between 2011 and 2013. The overall five-year survival rate for patients treated with curative intent was 73%, with 5-FU and mitomycin being associated with a lower mortality compared to 5-FU and cisplatin.
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.
