Akt isoforms in the immune system

AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus

(2022) Xin Zheng et al.   EMBO JOURNAL

Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival

(2021) Junming He et al.   Frontiers in Immunology

Hyperlipidemia‐induced metabolic changes in regulatory T cells result in altered function

(2021) Michael Hyde et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair

(2021) Xiaqiong Wang et al.   IMMUNITY

LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity

(2021) Doumet Georges Helou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells

(2021) Nital Sumaria et al.   Science Signaling

Cellular model system to dissect the isoform-selectivity of Akt inhibitors

(2021) Lena Quambusch et al.   Nature Communications

BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-κB and PI3K/AKT Signaling During Infection

(2020) Yuhui Miao et al.   Frontiers in Immunology

AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupting tissue remodeling

(2020) Song Gu et al.   Aging-US

Leptin Regulated ILC2 Cell through the PI3K/AKT Pathway in Allergic Rhinitis

(2020) Qingxiang Zeng et al.   MEDIATORS OF INFLAMMATION

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

(2019) Thiago A. Patente et al.   Frontiers in Immunology

Myeloid Cells during Viral Infections and Inflammation

(2019) Ashley A. Stegelmeier et al.   Viruses-Basel

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response

(2019) Ryuichi Nagashima et al.   JOURNAL OF IMMUNOLOGY

Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells

(2019) Song Ouyang et al.   JOURNAL OF IMMUNOLOGY

GC B cells ‘AKT’ to blunt BCR signaling

(2019) Julie Zikherman   NATURE IMMUNOLOGY

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

(2019) Wei Luo et al.   NATURE IMMUNOLOGY

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

(2019) Ali S. Alzahrani   SEMINARS IN CANCER BIOLOGY

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

Akt3-Mediated Protection Against Inflammatory Demyelinating Disease

(2019) Juwen C. DuBois et al.   Frontiers in Immunology

Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity

(2019) Lena Quambusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic Reprogramming in Mitochondria of Myeloid Cells

(2019) Hao Zuo et al.   Cells

CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1

(2018) Sara A. Gibson et al.   JOURNAL OF IMMUNOLOGY

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

(2018) Jake S. O’Donnell et al.   SEMINARS IN CANCER BIOLOGY

mTORC1 and mTORC2 differentially promote natural killer cell development

(2018) Chao Yang et al.   eLife

New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

(2018) Klaudia Szymonowicz et al.   Cancers

Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma: a potential role for the chemokine CXCL16

(2018) Yan Li et al.   Cellular & Molecular Immunology

Developmental origins of murine γδ T cell subsets

(2018) Nital Sumaria et al.   IMMUNOLOGY

The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells

(2018) Yufeng Wang et al.   NATURE IMMUNOLOGY

Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway

(2017) Liang Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γδTCR recruits the Syk/PI3K axis to drive proinflammatory differentiation program

(2017) Ryunosuke Muro et al.   JOURNAL OF CLINICAL INVESTIGATION

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

(2017) Barbara Castella et al.   Nature Communications

High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

(2017) Antoine Marçais et al.   eLife

AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease

(2016) Alexandra Kitz et al.   EMBO REPORTS

Dendritic cell maturation and cross-presentation: timing matters!

(2016) Andrés Alloatti et al.   IMMUNOLOGICAL REVIEWS

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

(2016) S T Ribeiro et al.   LEUKEMIA

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

(2016) Chong T. Luo et al.   NATURE

Dendritic cells as gatekeepers of tolerance

(2016) Ari Waisman et al.   Seminars in Immunopathology

Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration

(2015) Amitava Das et al.   AMERICAN JOURNAL OF PATHOLOGY

Cutting Edge: An In Vivo Reporter Reveals Active B Cell Receptor Signaling in the Germinal Center

(2015) James Mueller et al.   JOURNAL OF IMMUNOLOGY

PTEN Is a Negative Regulator of NK Cell Cytolytic Function

(2015) Edward L. Briercheck et al.   JOURNAL OF IMMUNOLOGY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8+T-cell proliferation and survival

(2015) Rasha Abu Eid et al.   OncoImmunology

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

The Critical Role of IL-15–PI3K–mTOR Pathway in Natural Killer Cell Effector Functions

(2014) Neethi Nandagopal et al.   Frontiers in Immunology

Kinase AKT controls innate immune cell development and function

(2013) Yan Zhang et al.   IMMUNOLOGY

Butyrophilin-like 2 Modulates B7 Costimulation To Induce Foxp3 Expression and Regulatory T Cell Development in Mature T Cells

(2013) R. M. Swanson et al.   JOURNAL OF IMMUNOLOGY

Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling

(2013) V. Tsiperson et al.   JOURNAL OF IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

Induction of IL-4R -dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo

(2012) D. Ruckerl et al.   BLOOD

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice

(2012) Liang Ding et al.   Cell Metabolism

Sin1 regulates Treg-cell development but is not required for T-cell growth and proliferation

(2012) Xing Chang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protein Kinase C-  Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a-Dependent Pathway

(2012) J. Ma et al.   JOURNAL OF IMMUNOLOGY

The Akt1 Isoform Is Required for Optimal IFN-  Transcription through Direct Phosphorylation of  -Catenin

(2012) B. N. Gantner et al.   JOURNAL OF IMMUNOLOGY

mTORC2-PKBα/Akt1 Serine 473 Phosphorylation Axis Is Essential for Regulation of FOXP3 Stability by Chemokine CCL3 in Psoriasis

(2012) Ling Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Novel Foxo1-dependent transcriptional programs control Treg cell function

(2012) Weiming Ouyang et al.   NATURE

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY

(2012) S. A. Ezell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity

(2012) A. M. Khalil et al.   SCIENCE

Differentiation of human peripheral blood V 1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells

(2011) D. V. Correia et al.   BLOOD

Cutting Edge: PHLPP Regulates the Development, Function, and Molecular Signaling Pathways of Regulatory T Cells

(2011) S. J. Patterson et al.   JOURNAL OF IMMUNOLOGY

Regulation of Na+/H+ exchanger in dendritic cells by Akt2

(2011) Madhuri Bhandaru et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hematopoietic stem and progenitor cell trafficking

(2011) Irina B. Mazo et al.   TRENDS IN IMMUNOLOGY

Plasmin Triggers Chemotaxis of Monocyte-Derived Dendritic Cells Through an Akt2-Dependent Pathway and Promotes a T-Helper Type-1 Response

(2010) Xuehua Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to    T-cell cytotoxicity

(2010) T. Lanca et al.   BLOOD

IL-10 inhibits the starvation induced autophagy in macrophages via class I phosphatidylinositol 3-kinase (PI3K) pathway

(2010) Hun-Jung Park et al.   MOLECULAR IMMUNOLOGY

Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia

(2009) Y. Yamanaka et al.   BLOOD

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

(2009) Ariadne Androulidaki et al.   IMMUNITY

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein Kinase B/Akt Signals Impair Th17 Differentiation and Support Natural Regulatory T Cell Function and Induced Regulatory T Cell Formation

(2009) M. Pierau et al.   JOURNAL OF IMMUNOLOGY

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA