Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells

Contribution of EAE to understanding and treating multiple sclerosis

(2017) Amy E. Lovett-Racke   JOURNAL OF NEUROIMMUNOLOGY

IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation

(2016) Lior Mayo et al.   BRAIN

AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease

(2016) Alexandra Kitz et al.   EMBO REPORTS

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

(2016) Emily R. Mercadante et al.   Frontiers in Immunology

Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation

(2015) Yun Xiao et al.   JOURNAL OF IMMUNOLOGY

E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination

(2015) Yixia Zhao et al.   JOURNAL OF IMMUNOLOGY

T-bet Expression by Foxp3+ T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis

(2015) Rhoanne C. McPherson et al.   Frontiers in Immunology

Natural Naive CD4 + CD25 + CD127 low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

(2014) Koen Venken et al.   JOURNAL OF IMMUNOLOGY

E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation

(2014) Guilin Qiao et al.   Cell Reports

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

(2014) Michail Koutrolos et al.   Acta Neuropathologica Communications

T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells

(2013) G. Qiao et al.   JOURNAL OF IMMUNOLOGY

Suppression of Inflammatory Responses during Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis Is Regulated by AKT3 Signaling

(2013) V. Tsiperson et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Akt Fine-tunes NF-κB-dependent Gene Expression during T Cell Activation

(2011) Jing Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

(2010) Yohsuke Harada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: CTLA-4-B7 Interaction Suppresses Th17 Cell Differentiation

(2010) H. Ying et al.   JOURNAL OF IMMUNOLOGY

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

(2010) Weiming Ouyang et al.   NATURE IMMUNOLOGY

Soft Tissue Sarcoma Cells Are Highly Sensitive to AKT Blockade: A Role for p53-Independent Up-regulation of GADD45 

(2008) Q.-S. Zhu et al.   CANCER RESEARCH

Multiple Sclerosis and Regulatory T Cells

(2008) Cristina Maria Costantino et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease

(2008) Richard A. O'Connor et al.   JOURNAL OF NEUROIMMUNOLOGY

T-Cell Receptor-Induced NF- B Activation Is Negatively Regulated by E3 Ubiquitin Ligase Cbl-b

(2008) G. Qiao et al.   MOLECULAR AND CELLULAR BIOLOGY

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of regulatory T cells in multiple sclerosis

(2008) Alla L Zozulya et al.   Nature clinical practice. Neurology