Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

(2017) Marina Riggio et al.   Scientific Reports

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor

(2016) Jean-Marc Lapierre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Covalent-Allosteric Kinase Inhibitors

(2015) Jörn Weisner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Discovery of Inter-Domain Stabilizers—A Novel Assay System for Allosteric Akt Inhibitors

(2014) Zhizhou Fang et al.   ACS Chemical Biology

Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression

(2014) Nicolle M. Linnerth-Petrik et al.   PLoS One

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

Proteus in the World of Proteins: Conformational Changes in Protein Kinases

(2010) Matthias Rabiller et al.   ARCHIV DER PHARMAZIE

The Akt isoforms are present at distinct subcellular locations

(2009) Stacey A. Santi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Isoform-selective histone deacetylase inhibitors

(2008) Anton V. Bieliauskas et al.   CHEMICAL SOCIETY REVIEWS

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE