The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

(2017) Charlotte Viant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PI3K inhibitor LY294002, as opposed to wortmannin, enhances AKT phosphorylation in gemcitabine-resistant pancreatic cancer cells

(2016) Yufeng Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion

(2016) D. Gotthardt et al.   Cancer Discovery

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Transcription Factor Foxo1 Is a Negative Regulator of Natural Killer Cell Maturation and Function

(2015) Youcai Deng et al.   IMMUNITY

The transcription factor XBP1 is selectively required for eosinophil differentiation

(2015) Sarah E Bettigole et al.   NATURE IMMUNOLOGY

Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

(2015) Daichao Xu et al.   eLife

Genetic Modification of T Cells Redirected toward CS1 Enhances Eradication of Myeloma Cells

(2014) J. Chu et al.   CLINICAL CANCER RESEARCH

Endoplasmic Reticulum Stress Regulator XBP-1 Contributes to Effector CD8+ T Cell Differentiation during Acute Infection

(2014) D. Kamimura et al.   JOURNAL OF IMMUNOLOGY

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

(2014) Khaled Ali et al.   NATURE

The Critical Role of IL-15–PI3K–mTOR Pathway in Natural Killer Cell Effector Functions

(2014) Neethi Nandagopal et al.   Frontiers in Immunology

Unspliced XBP1 controls autophagy through FoxO1

(2013) Rene L Vidal et al.   CELL RESEARCH

CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma

(2013) J Chu et al.   LEUKEMIA

NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation

(2013) Stephan Meinke et al.   Frontiers in Immunology

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heightened Induction of Proapoptotic Signals in Response to Endoplasmic Reticulum Stress in Primary Fibroblasts from a Mouse Model of Longevity

(2011) Amir A. Sadighi Akha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion

(2009) B. Jahrsdorfer et al.   BLOOD

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response

(2009) A. Uemura et al.   JOURNAL OF CELL SCIENCE

Leukemic challenge unmasks a requirement for PI3K  in NK cell-mediated tumor surveillance

(2008) E. Zebedin et al.   BLOOD

The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation

(2008) Hailong Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE