Article
Biology
Galen F. Gao, Dajiang Liu, Xiaowei Zhan, Bo Li
Summary: In this study, a method for identifying KIR allele variants from whole exome sequencing data was developed. The researchers discovered novel associations between these variants and various molecular and clinical correlates.
Article
Hematology
Haojie Jiang, Lin Zhang, Mina Yang, Guoming Li, Chen Ding, Min Xin, Jing Dai, Xueqing Sun, Xuemei Fan, Haipeng Sun, Junling Liu, Yanyan Xu
Summary: This study reveals the important role of BCAAs in megakaryocyte differentiation and platelet production. BCAA diet can promote megakaryocyte differentiation and platelet production, while deficiency in BCAA metabolism leads to thrombocythemia. Activation of BCAA metabolism can reduce thrombocythemia.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Neurosciences
Tiantian Wang, Mingshan Zhou, Quan Zhang, Cuizhen Zhang, Gang Peng
Summary: The study revealed that ubtor regulates motor hyperactivity and epilepsy-like behaviors by elevating neuronal activity and activating mTOR signaling.
NEUROSCIENCE BULLETIN
(2021)
Article
Immunology
Berna Bou-Tayeh, Vladimir Laletin, Nassim Salem, Sylvaine Just-Landi, Joanna Fares, Raphael Leblanc, Marielle Balzano, Yann M. Kerdiles, Ghislain Bidaut, Olivier Herault, Daniel Olive, Michel Aurrand-Lions, Thierry Walzer, Jacques A. Nunes, Cyril Fauriat
Summary: NK cells in AML patients exhibit defects in maturation and function due to chronic cytokine activation, particularly IL-15/mTOR signaling, leading to metabolic and functional exhaustion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Senlian Hong, Chenhua Yu, Emily Rodrigues, Yujie Shi, Hongmin Chen, Peng Wang, Digantkumar G. Chapla, Tao Gao, Ruoxuan Zhuang, Kelley W. Moremen, James C. Paulson, Matthew S. Macauley, Peng Wu
Summary: Siglecs are identified as glyco-immune checkpoints that modulate signaling cascades on innate and adaptive immune cells through interactions with sialylated glycan ligands overexpressed on tumor cells. NK cells induce glycan remodeling on target cells at the immunological synapse, which can enhance NK effector functions for related applications. Glycan engineering of NK cells may provide a means to boost NK cytotoxicity through the modulation of Siglec-7-regulated NK activation.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Vlad Andrei Cianga, Lydia Campos Catafal, Petru Cianga, Mariana Pavel Tanasa, Mohamad Cherry, Phillipe Collet, Emmanuelle Tavernier, Denis Guyotat, Cristina Rusu, Carmen Mariana Aanei
Summary: The study investigated NK cell maturation in bone marrow under different conditions and found impaired NK cell antitumor response and phenotypic shift in MDS and AML settings. The results suggest immune response failure during myeloid malignancy pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Lei Cao, Hongsheng Liu, Cheng Huang, Chao Guo, Luo Zhao, Chao Gao, Yuan Xu, Guige Wang, Naixin Liang, Shanqing Li
Summary: This study aimed to investigate the mechanisms of lung cancer and develop an effective therapeutic approach. The researchers found that USP5 is highly expressed in lung cancer and promotes the proliferation and migration of lung cancer cells through the PARP1-mediated mTOR signaling pathway. Silencing USP5 significantly reduced the volume of subcutaneous tumors, while overexpression of USP5 and shRARP1 treatment led to a significant increase and decrease in tumor size, respectively. These findings suggest that USP5 could be a potential new target for lung cancer treatment.
Article
Immunology
Yunhee Lee, Arum Park, Young-Jun Park, Haiyoung Jung, Tae-Don Kim, Ji-Yoon Noh, Inpyo Choi, Seungjin Lee, Suk Ran Yoon
Summary: G-Rg3 promotes NK cell cytotoxicity and activates the MAPK/ERK pathway. It increases the expression of NK-activating receptors and cytolytic molecules, while not affecting NK cell differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Jun Luo, Yoshinobu Odaka, Zhu Huang, Bing Cheng, Wang Liu, Lin Li, Chaowei Shang, Chao Zhang, Yang Wu, Yan Luo, Shengyong Yang, Peter J. Houghton, Xiaofeng Guo, Shile Huang
Summary: Dihydroartemisinin (DHA) inhibits mTORC1 by activating AMPK in tumor cells, which leads to reduced proliferation and viability of tumor cells. This study suggests that DHA or its derivative artesunate has the potential to be repurposed for the treatment of RMS.
Article
Medicine, Research & Experimental
Jishang Huang, Zhixi Chen, Zhenyu Wu, Xunlu Xie, Shiwei Liu, Weihao Kong, Jianguo Zhou
Summary: The study found that geniposide can stimulate autophagy and protect against the development of osteoarthritis by activating the GLP-1R/AMPK/mTOR signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Shu-xian Li, Chao Li, Xin-ru Pang, Juan Zhang, Gong-chang Yu, Abrey J. Yeo, Martin F. Lavin, Hua Shao, Qiang Jia, Cheng Peng
Summary: Long-term exposure to crystalline silica particles leads to silicosis, for which there is currently no specific treatment. The study found that metformin can alleviate inflammation and fibrosis in the lungs of silicosis patients by activating autophagy through the AMPK-mTOR pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin
Summary: SPOCK1 plays a crucial role in breast cancer progression by promoting cell proliferation and metastasis, making it a promising clinical therapeutic target for preventing the progression of breast cancer.
Article
Medicine, Research & Experimental
Eleanor C. Semmes, Itzayana G. Miller, Nicole Rodgers, Caroline T. Phan, Jillian H. Hurst, Kyle M. Walsh, Richard J. Stanton, Justin Pollara, Sallie R. Permar
Summary: Human cytomegalovirus (HCMV) is a common vertically transmitted infection worldwide, but there are currently no vaccines or therapeutics to prevent congenital HCMV (cCMV) infection. Recent evidence suggests that antibody Fc effector functions may play an important role in maternal immunity against HCMV. This study demonstrates that antibody-dependent cellular cytotoxicity (ADCC) activation is associated with a lower risk of cCMV transmission, providing insights for future research and vaccine development.
Article
Immunology
Francesco Colucci
Summary: I argue in this review that reproduction was a driving force in the evolution of NK cell education, which is set by interactions between inhibitory receptors and self-MHC. The maternal immune system's tolerance of the semiallogeneic fetus is a fascinating question. Tissue lymphocytes, like uterine NK cells, do not attack the mismatched fetus and its placenta, but instead help the local vasculature tolerate changes necessary to nourish the fetus.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Baige Yao, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Lili Wang, Shuju Zhang, Minghui Huang, Erqiang Wang, Peiwen Xiong, Ting Luo, Liping Li, Sujie Jia, Yafei Deng, Youcai Deng
Summary: The study identified Daphnetin as a natural product capable of promoting human NK cell activation via the PI3K-Akt-mTOR signaling pathway in the presence of IL-12, also enhancing its direct cytotoxicity against tumor cells. The findings suggest a potential application for Daphnetin as a complementary immunomodulator in cancer treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Oncology
Audrone Muleviciene, Takuya Sekine, Timo Zondag, Yenan T. Bryceson, Bianca Tesi, Jelena Rascon
PEDIATRIC BLOOD & CANCER
(2022)
Article
Cell Biology
Xavier Charmetant, Maxime Espi, Ilies Benotmane, Veronique Barateau, Francoise Heibel, Fanny Buron, Gabriela Gautier-Vargas, Marion Delafosse, Peggy Perrin, Alice Koenig, Noelle Cognard, Charlene Levi, Floriane Gallais, Louis Maniere, Paola Rossolillo, Eric Soulier, Florian Pierre, Anne Ovize, Emmanuel Morelon, Thierry Defrance, Samira Fafi-Kremer, Sophie Caillard, Olivier Thaunat
Summary: Transplant recipients treated with immunosuppression have a lower response to COVID-19 vaccines, but previous infection with SARS-CoV-2 provides some protection. A study found that neutralizing anti-RBD IgG antibodies were the primary correlate of protection for transplant recipients. Immunosuppressive drugs may affect the generation of virus-specific B and T follicular helper cells. Administration of a third dose of SARS-CoV-2 mRNA vaccine improved the RBD-specific responses in transplant patients who had not previously responded to two doses of the vaccine.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Hannes Lindahl, Yenan T. Bryceson
Summary: The development of high-throughput sequencing has advanced the understanding of genotype-phenotype correlations in congenital diseases. Neuroinflammatory diseases, although rare, are increasingly recognized among inborn errors of immunity and can have a significant impact on patient care. This review focuses on the signs and symptoms of neuroinflammation associated with pathogenic variants in immune genes and proposes a subdivision based on underlying mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Pierre-Louis Bernard, Rebecca Delconte, Sonia Pastor, Vladimir Laletin, Cathy Costa Da Silva, Armelle Goubard, Emmanuelle Josselin, Remy Castellano, Adrien Krug, Julien Vernerey, Raynier Devillier, Daniel Olive, Els Verhoeyen, Eric Vivier, Nicholas D. Huntington, Jacques Nunes, Geoffrey Guittard
Summary: This study investigates the impact of targeting an inhibiting protein called CISH in natural killer (NK) cells on their functions and antitumor properties. The results show that CISH deletion enhances NK cell activation and killing abilities, while limiting NK cell exhaustion. Furthermore, CISH deletion optimizes NK cell accumulation in tumors and improves the effectiveness of antitumor responses. Therefore, CISH has been validated as a potential therapeutic target to enhance NK cell immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Valeria Fumagalli, Valentina Venzin, Pietro Di Lucia, Federica Moalli, Xenia Ficht, Gioia Ambrosi, Leonardo Giustini, Francesco Andreata, Marta Grillo, Diletta Magini, Micol Rava, Christin Friedrich, Jason D. Fontenot, Philippe Bousso, Sarah A. Gilmore, Shahzada Khan, Manuel Baca, Eric Vivier, Georg Gasteiger, Mirela Kuka, Luca G. Guidotti, Matteo Iannacone
Summary: Group 1 innate lymphoid cells (ILCs) play a role in controlling T cell-mediated liver immunopathology by limiting local IL-2 concentration.
SCIENCE IMMUNOLOGY
(2022)
Article
Transplantation
Antonin Bouchet, Brieuc Muller, Jerome Olagne, Thomas Barba, Melanie Joly, Augustin Obrecht, Maud Rabeyrin, Frederique Dijoud, Cecile Picard, Sarah Mezaache, Antoine Sicard, Alice Koenig, Anne Parissiadis, Valerie Dubois, Emmanuel Morelon, Sophie Caillard, Olivier Thaunat
Summary: For renal transplant recipients, a follow-up biopsy conducted 3-6 months after AMR treatment initiation can help predict long-term outcomes. The evolution of humoral lesions is closely associated with graft survival rates.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biotechnology & Applied Microbiology
Laurent Gauthier, Angela Virone-Oddos, Jochen Beninga, Benjamin Rossi, Celine Nicolazzi, Celine Amara, Audrey Blanchard-Alvarez, Nicolas Gourdin, Jacqueline Courta, Alexandra Basset, Magali Agnel, Franceline Guillot, Gwendoline Grondin, Helene Bonnevaux, Anne-Laure Bauchet, Ariane Morel, Yannis Morel, Marielle Chiron, Eric Vivier
Summary: Researchers have developed a novel natural killer cell engager (NKCE) that targets leukemia cells and has potent antitumor activity without toxicity, suggesting its potential for clinical development.
NATURE BIOTECHNOLOGY
(2023)
Letter
Critical Care Medicine
Julien Carvelli, Eric Vivier
CRITICAL CARE MEDICINE
(2023)
Article
Cell Biology
Veronique Barateau, Loic Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, Mad-Helenie Elsensohn, Omran Allatif, Nicolas Guibert, Christelle Compagnon, Natacha Mariano, Julie Chaix, Sophia Djebali, Jean-Baptiste Fassier, Bruno Lina, Katia Lefsihane, Maxime Espi, Olivier Thaunat, Jacqueline Marvel, Manuel Rosa-Calatrava, Andres Pizzorno, Delphine Maucort-Boulch, Laetitia Henaff, Mitra Saadatian-Elahi, Philippe Vanhems, Stephane Paul, Thierry Walzer, Sophie Trouillet-Assant, Thierry Defrance
Summary: The history of infection and vaccination modality impact the immune memory of individuals vaccinated against SARS-CoV-2. A long-term follow-up study was conducted on unvaccinated and vaccinated COVID-19 convalescent individuals, as well as infection-naive vaccinated individuals, to understand how these factors affect immune memory. The study found that convalescent vaccinated individuals had the highest concentrations of spike protein-specific antibodies and increased frequencies of a specific memory B cell subset, suggesting enhanced protection at mucosal sites.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Noella Lopes, Eric Vivier, Emilie Narni-Mancinelli
Summary: The article introduces the developmental trajectory and cytokine production profile of innate lymphoid cells (ILCs). It describes the subsets, effector functions, and development of NK cells and ILC1s, and discusses their role in cancer and the effects of the tumor microenvironment on their metabolism.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Franck Zekre, Anita Duncan, Audrey Laurent, Maud Tusseau, Remi Pescarmona, Sophie Collardeau-Frachon, Camille Ohlmann, Sebastien Viel, Philippe Reix, Sarah Benezech, Alexandre Belot
Summary: Biological disease-modifying anti-rheumatic drugs (bDMARDs) targeting IL-6 and IL-1 beta are commonly used as a first-line therapy for systemic-onset juvenile idiopathic arthritis (sJIA), but they may increase the risk of pulmonary alveolar proteinosis (PAP). We report a new case of PAP-MAS successfully treated with Janus Kinase inhibitors (JAKi) and review previous clinical descriptions of this condition. Among the analyzed articles, the incidence of PAP-MAS among sJIA patients ranged from 1.28% to 12.9%. JAKi shows promise in treating lung disease associated with sJIA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Hanif J. Khameneh, Nicolas Fonta, Alessandro Zenobi, Charlene Niogret, Pedro Ventura, Concetta Guerra, Ivo Kwee, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Andrea Cavalli, Francesco Bertoni, Eric Vivier, Andreas Trumpp, Greta Guarda
Summary: This study reveals the importance of MYC in NK cells and its role in regulating translation and expansion, as well as anticancer immunity. Deficiency of MYC in NK cells results in reduced numbers and impaired cytotoxic functions of mature NK cells.
LIFE SCIENCE ALLIANCE
(2023)
Editorial Material
Rheumatology
Anais Nombel, Anne Perrine Foray, Lorna Garnier, Christine Lombard, Eric Hachulla, Brigitte Bader-Meunier, Sophie Georgin-Lavialle, Isabelle Melki, Thierry Walzer, Alexandre Belot, Sebastien Viel
Summary: An European Alliance of Associations for Rheumatology task force has suggested specific considerations for studying the type I interferon pathway, noting the lack of validated assays for clinical use. In this report, we present the French experience of using a type I interferon pathway assay routinely since 2018 in Lyon, France.
Article
Biotechnology & Applied Microbiology
Sridhar Selvaraj, William N. Feist, Sebastien Viel, Sriram Vaidyanathan, Amanda M. Dudek, Marc Gastou, Sarah J. Rockwood, Freja K. Ekman, Aluya R. Oseghale, Liwen Xu, Mara Pavel-Dinu, Sofia E. Luna, M. Kyle Cromer, Ruhi Sayana, Natalia Gomez-Ospina, Matthew H. Porteus
Summary: A small molecule inhibitor called AZD7648 was found to significantly increase the efficiency of homology-directed repair (HDR) and decrease genomic insertions/deletions (INDELs) in human primary cells. This approach has the potential to improve therapeutic efficacy of cell-based therapies and expand the use of targeted integration as a research tool.
NATURE BIOTECHNOLOGY
(2023)
Review
Immunology
Eve Playoust, Romain Remark, Eric Vivier, Pierre Milpied
Summary: B cells are crucial for immunity and are involved in affinity maturation and differentiation through B-cell receptor signals and signals from the microenvironment. They have been discovered to play important roles in antitumor responses in human cancers, but their dynamics and interplay are not well understood. B-cell responses involve both GC-dependent and GC-independent pathways, with affinity maturation occurring in GC reactions. Reactivation of high-affinity Bmem cells leads to the production of large numbers of PCs without BCR rediversification. Multiple tools and techniques are needed to understand B-cell dynamics in immune responses. Studying TIL-B cells and TIL-PC in solid tumors can provide insights for antitumor therapies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
