Kinase AKT controls innate immune cell development and function

Antimony-resistant but not antimony-sensitive Leishmania donovani up-regulates host IL-10 to overexpress multidrug-resistant protein 1

(2013) B. Mukherjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

(2012) So Young Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function

(2012) L. van de Laar et al.   BLOOD

HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells

(2012) J. Florentin et al.   BLOOD

Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1

(2012) G. Liu et al.   BLOOD

mTOR Regulates T-Cell Differentiation and Activation in Immunity and Autoimmunity

(2012) Yujing Bi et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury

(2012) Yuping Lai et al.   IMMUNITY

Infection with Anaplasma phagocytophilum Activates the Phosphatidylinositol 3-Kinase/Akt and NF-κB Survival Pathways in Neutrophil Granulocytes

(2012) Arup Sarkar et al.   INFECTION AND IMMUNITY

AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells

(2012) Wenying Zou et al.   INFLAMMATION RESEARCH

TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase-Rac Pathway

(2012) H. Sun et al.   JOURNAL OF IMMUNOLOGY

The Akt1 Isoform Is Required for Optimal IFN-  Transcription through Direct Phosphorylation of  -Catenin

(2012) B. N. Gantner et al.   JOURNAL OF IMMUNOLOGY

Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity

(2012) Guangwei Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Common Genetic Variations in the NALP3 Inflammasome Are Associated with Delayed Apoptosis of Human Neutrophils

(2012) Robert Blomgran et al.   PLoS One

TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice

(2012) Lianjun Zhang et al.   PLoS One

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIG-like Helicase Innate Immunity Inhibits Vascular Endothelial Growth Factor Tissue Responses via a Type I IFN–dependent Mechanism

(2011) Bing Ma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis

(2011) H. S. Jun et al.   BLOOD

Rac regulates PtdInsP3 signaling and the chemotactic compass through a redox-mediated feedback loop

(2011) J. W. P. Kuiper et al.   BLOOD

Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF

(2011) Verena Schwartz et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

An instructive role of donor macrophages in mixed chimeras in the induction of recipient CD4+ Foxp3+ Treg cells

(2011) Guangwei Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Selective Signaling by Akt1 Controls Osteoblast Differentiation and Osteoblast-Mediated Osteoclast Development

(2011) A. Mukherjee et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-Bacterial Effects of Poly-N-Acetyl-Glucosamine Nanofibers in Cutaneous Wound Healing: Requirement for Akt1

(2011) Haley Buff Lindner et al.   PLoS One

Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity

(2011) Q. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response

(2010) Wei Wang et al.   ACTA PHARMACOLOGICA SINICA

Akt isoforms differentially regulate neutrophil functions

(2010) J. Chen et al.   BLOOD

The role of mTOR in memory CD8+ T-cell differentiation

(2010) Koichi Araki et al.   IMMUNOLOGICAL REVIEWS

Human CD34-Derived Myeloid Dendritic Cell Development Requires Intact Phosphatidylinositol 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling

(2010) L. van de Laar et al.   JOURNAL OF IMMUNOLOGY

The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

HIV-1 Inhibits Autophagy in Bystander Macrophage/Monocytic Cells through Src-Akt and STAT3

(2010) Jennifer Van Grol et al.   PLoS One

Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3K , ROS, and actin

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells

(2009) Arpad Boronkai et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils

(2009) Ling-Chu Chang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway

(2009) Benedetta Mattioli et al.   FEBS LETTERS

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

(2009) Ariadne Androulidaki et al.   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Nuclear Factor (NF)-κB-dependent Thyroid Hormone Receptor β1Expression Controls Dendritic Cell Function via Akt Signaling

(2009) Iván D. Mascanfroni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidoglycan Enhances IL-6 Production in Human Synovial Fibroblasts via TLR2 Receptor, Focal Adhesion Kinase, Akt, and AP-1- Dependent Pathway

(2009) Y.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

A novel modifier of regulatory T cells

(2009) Naganari Ohkura et al.   NATURE IMMUNOLOGY

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD)

(2009) D.-C. Fischer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

(2008) T Weichhart et al.   ANNALS OF THE RHEUMATIC DISEASES

BK channels in innate immune functions of neutrophils and macrophages

(2008) K. Essin et al.   BLOOD

An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption

(2008) B S Herrera et al.   BRITISH JOURNAL OF PHARMACOLOGY

MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis

(2008) Ling Kong et al.   CELL RESEARCH

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AKT1-Dependent Activation of NF- B by the L Protein of Parainfluenza Virus 5

(2008) P. Luthra et al.   JOURNAL OF VIROLOGY

Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration

(2008) Takanari Inoue et al.   PLoS One

Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis

(2008) Y. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium

(2008) Laura M. Beaver et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY