Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

(2016) A. R. Almeida et al.   CLINICAL CANCER RESEARCH

A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

(2016) Hyeongki Kim et al.   Disease Models & Mechanisms

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

(2016) Miguel Muñoz-Ruiz et al.   NATURE IMMUNOLOGY

Akt/PKB: one kinase, many modifications

(2015) Guillermo Risso et al.   BIOCHEMICAL JOURNAL

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia

(2015) C. Song et al.   BLOOD

Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo

(2015) Alexander Ulges et al.   NATURE IMMUNOLOGY

Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

(2015) Nina Schmolka et al.   SEMINARS IN IMMUNOLOGY

Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation

(2015) Sérgio T. Ribeiro et al.   Frontiers in Immunology

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

(2014) A. M. Gomes et al.   HAEMATOLOGICA

Human    Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling

(2014) J. C. Ribot et al.   JOURNAL OF IMMUNOLOGY

A Network of High-Mobility Group Box Transcription Factors Programs Innate Interleukin-17 Production

(2013) Nidhi Malhotra et al.   IMMUNITY

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

(2013) F Buontempo et al.   LEUKEMIA

PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2

(2013) Nikolaos Patsoukis et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein kinase CK2 inhibitors: a patent review

(2012) Giorgio Cozza et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

CD5-Dependent CK2 Activation Pathway Regulates Threshold for T Cell Anergy

(2012) C. M. Sestero et al.   JOURNAL OF IMMUNOLOGY

B7-CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human    T Cells via IL-2 Production

(2012) J. C. Ribot et al.   JOURNAL OF IMMUNOLOGY

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

(2012) F Piazza et al.   LEUKEMIA

Novel players in multiple myeloma pathogenesis: Role of protein kinases CK2 and GSK3

(2012) Francesco Piazza et al.   LEUKEMIA RESEARCH

Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation

(2012) S Koch et al.   Mucosal Immunology

Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

(2010) Tatyana Adayev et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia

(2010) L. R. Martins et al.   BLOOD

Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia

(2010) M. Shehata et al.   BLOOD

Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties

(2010) M. Buitenhuis et al.   BLOOD

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

(2010) A. Siddiqui-Jain et al.   CANCER RESEARCH

CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes

(2010) Ana deBarros et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Akt inhibitors in clinical development for the treatment of cancer

(2010) Sumanta Kumar Pal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Phosphorylation of AKT/PKB by CK2 is necessary for the AKT-dependent up-regulation of β-catenin transcriptional activity

(2010) Daniela P. Ponce et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protein Kinase CK2 in Health and Disease

(2009) J. H. Trembley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Marked Induction of the Helix-Loop-Helix Protein Id3 Promotes the γδ T Cell Fate and Renders Their Functional Maturation Notch Independent

(2009) Jens Peter Holst Lauritsen et al.   IMMUNITY

CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

(2009) Julie C Ribot et al.   NATURE IMMUNOLOGY

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION