Biological Mechanisms and Related Natural Inhibitors of CD36 in Nonalcoholic Fatty Liver

Inhibition of fatty acid translocase (FAT/CD36) palmitoylation enhances hepatic fatty acid β-oxidation by increasing its localization to mitochondria and interaction with long-chain acyl-CoA synthetase 1

(2022) Shu Zeng et al.   ANTIOXIDANTS & REDOX SIGNALING

Betaine Alleviates High-Fat Diet-Induced Disruption of Hepatic Lipid and Iron Homeostasis in Mice

(2022) Yanlin Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pretreatment of hydroethanolic extract of Dillenia indica L. attenuates oleic acid induced NAFLD in HepG2 cells via modulating SIRT-1/p-LKB-1/AMPK, HMGCR & PPAR-α signaling pathways

(2022) M.S. Poornima et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ficus hirta Vahl. Ameliorates Nonalcoholic Fatty Liver Disease through Regulating Lipid Metabolism and Gut Microbiota

(2022) Ting Quan et al.   Oxidative Medicine and Cellular Longevity

Abelmoschus esculentus subfractions ameliorate hepatic lipogenesis and lipid uptake via regulating dipeptidyl peptidase-4—With improving insulin resistance

(2022) Chiung-Huei Peng et al.   PLoS One

Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond

(2022) Nabil G. Seidah et al.   Current Atherosclerosis Reports

Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice

(2022) Zhuohui Zhao et al.   Nutrients

Puerarin ameliorates nonalcoholic fatty liver in rats by regulating hepatic lipid accumulation, oxidative stress, and inflammation

(2022) Jingxuan Zhou et al.   Frontiers in Immunology

Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation

(2022) Marcella Palumbo et al.   Frontiers in Molecular Biosciences

Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice

(2022) Ling-Cui Meng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

(2021) Yana Geng et al.   Hepatology International

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36

(2021) Chen Shen et al.   FEBS LETTERS

Naringin prevents cyclophosphamide-induced hepatotoxicity in rats by attenuating oxidative stress, fibrosis, and inflammation

(2021) Adio J. Akamo et al.   FOOD AND CHEMICAL TOXICOLOGY

β-patchoulene protects against non-alcoholic steatohepatitis via interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation in rats

(2021) Huijuan Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Naringin improves lipid metabolism in a tissue-engineered liver model of NAFLD and the underlying mechanisms

(2021) Xiaohui Zhang et al.   LIFE SCIENCES

Autophagy in liver diseases: A review

(2021) Hui Qian et al.   MOLECULAR ASPECTS OF MEDICINE

MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice

(2021) Christian Smolka et al.   MOLECULAR MEDICINE

β-Patchoulene Ameliorates Water Transport and the Mucus Barrier in 5-Fluorouracil-Induced Intestinal Mucositis Rats via the cAMP/PKA/CREB Signaling Pathway

(2021) Jiazhen Wu et al.   Frontiers in Pharmacology

Epigenetic Regulation of Peroxisome Proliferator-Activated Receptor Gamma Mediates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease

(2021) Tahar Hajri et al.   Cells

CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting

(2021) Udayakumar Karunakaran et al.   Cells

Ethanol Extract of Liriope platyphylla Root Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice via Regulation of Lipogenesis and Lipid Uptake

(2021) Trang Nu Huyen Le et al.   Nutrients

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

(2021) Han Zeng et al.   Molecular Metabolism

Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR

(2020) Ping Yang et al.   FASEB JOURNAL

Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of Nonalcoholic Fatty Liver Disease

(2020) James M. Paik et al.   HEPATOLOGY

Sweroside ameliorates NAFLD in high-fat diet induced obese mice through the regulation of lipid metabolism and inflammatory response

(2020) Qiaoling Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3

(2020) Chang-ling Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: A review

(2020) Kobra Shirani et al.   PHYTOTHERAPY RESEARCH

Rediscovery of natural compounds acting via multitarget recognition and noncanonical pharmacodynamical actions

(2020) Mariano Bizzarri et al.   DRUG DISCOVERY TODAY

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

(2020) Daqian Xu et al.   NATURE

Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes

(2020) Miori Tanaka et al.   Nutrients

Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid

(2020) Yue Gao et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Cinnamic Acid Derivatives and Their Biological Efficacy

(2020) Ngonidzashe Ruwizhi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1α-LIPIN 1 pathway and increasing CD36 through Nrf2

(2020) Emma Barroso et al.   Cell Communication and Signaling

Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro

(2020) Ni-Chun Kuo et al.   Antioxidants

β-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance

(2020) Yuhong Liu et al.   BIOCHEMICAL PHARMACOLOGY

Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases

(2020) Jinrong Bai et al.   BIOMEDICINE & PHARMACOTHERAPY

Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro

(2020) Dan Wei et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice

(2020) Marisa Pfohl et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Direct lysosome-based autophagy of lipid droplets in hepatocytes

(2020) Ryan J. Schulze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36

(2020) Xin Wang et al.   Frontiers in Cell and Developmental Biology

Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses

(2020) Xiaobao Gong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antifungal activity and action mechanism of the natural product cinnamic acid against Sclerotinia sclerotiorum

(2019) Yong Wang et al.   PLANT DISEASE

Role of Theobromine in Cocoa’s Metabolic Properties in Healthy Rats

(2019) Mariona Camps-Bossacoma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model

(2019) Zhengzheng Liao et al.   MOLECULES

Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo

(2019) Wonseok Lee et al.   PLANTA MEDICA

Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice

(2019) Bihui Liu et al.   Biomolecules

Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression

(2019) Xiaoqing Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice

(2019) Hung-Yu Lin et al.   Cells

The immunobiology of mTOR in autoimmunity

(2019) Takahito Suto et al.   JOURNAL OF AUTOIMMUNITY

Evolution of NAFLD and Its Management

(2019) Manpreet S. Mundi et al.   NUTRITION IN CLINICAL PRACTICE

Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice

(2018) Caixia Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis

(2018) Lei Zhao et al.   JOURNAL OF HEPATOLOGY

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity

(2018) Jiawen Zheng et al.   LIPIDS

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Liver X receptors in lipid signalling and membrane homeostasis

(2018) Bo Wang et al.   Nature Reviews Endocrinology

Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives

(2018) Takanori Tsuda   Food & Function

Dual-specificity Phosphatase 9 Protects Against Non-alcoholic Fatty Liver Disease in Mice via ASK1 Suppression

(2018) Ping Ye et al.   HEPATOLOGY

High-Content Screening of a Taiwanese Indigenous Plant Extract Library Identifies Syzygium simile leaf Extract as an Inhibitor of Fatty Acid Uptake

(2018) Chia-Hung Yen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Current and future pharmacological therapies for NAFLD/NASH

(2017) Yoshio Sumida et al.   JOURNAL OF GASTROENTEROLOGY

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Cinnamic Acid and Its Derivatives: Mechanisms for Prevention and Management of Diabetes and Its Complications

(2017) Sirichai Adisakwattana   Nutrients

mTORC1 signaling in hepatic lipid metabolism

(2017) Jinbo Han et al.   Protein & Cell

Anti-Inflammatory Effects of Liriope platyphylla in LPS-Stimulated Macrophages and Endotoxemic Mice

(2016) Min-Jee Kim et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Post-translational modifications of CD36 (SR-B2): Implications for regulation of myocellular fatty acid uptake

(2016) Joost J.F.P. Luiken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice

(2016) Liu Yao et al.   HEPATOLOGY

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is Involved in Lipid Disorder-Mediated Organ Injury

(2016) Yang Zhang et al.   International Journal of Biological Sciences

Molecular Pathogenesis of NASH

(2016) Alessandra Caligiuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circulating sCD36 levels in patients with non-alcoholic fatty liver disease and controls

(2016) S Heebøll et al.   INTERNATIONAL JOURNAL OF OBESITY

Water Extract ofDolichos lablabAttenuates Hepatic Lipid Accumulation in a Cellular Nonalcoholic Fatty Liver Disease Model

(2016) A-Rang Im et al.   JOURNAL OF MEDICINAL FOOD

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Anti-Inflammatory Activity of Natural Products

(2016) Abdullatif Azab et al.   MOLECULES

PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse LiverSignificance

(2015) Annie Demers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Quercetin Alleviates High-Fat Diet-Induced Oxidized Low-Density Lipoprotein Accumulation in the Liver: Implication for Autophagy Regulation

(2015) Liang Liu et al.   Biomed Research International

Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism

(2014) Marta Yanina Pepino et al.   Annual Review of Nutrition

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway

(2014) Shi-Hao Tan et al.   Autophagy

Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis

(2014) Chuan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Standardizing Scavenger Receptor Nomenclature

(2014) M. PrabhuDas et al.   JOURNAL OF IMMUNOLOGY

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Increased soluble CD36 is linked to advanced steatosis in nonalcoholic fatty liver disease

(2013) Carmelo García-Monzón et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease

(2011) Ingrid C. Gaemers et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease

(2011) Jinhan He et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

A Novel Role for the Dioxin Receptor in Fatty Acid Metabolism and Hepatic Steatosis

(2010) Jung Hoon Lee et al.   GASTROENTEROLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

PXR and LXR in Hepatic Steatosis: A New Dog and an Old Dog with New Tricks

(2007) Jung Hoon Lee et al.   MOLECULAR PHARMACEUTICS