Involvement of HO-1 and Autophagy in the Protective Effect of Magnolol in Hepatic Steatosis-Induced NLRP3 Inflammasome Activation In Vivo and In Vitro

Adipocyte Specific HO-1 Gene Therapy Is Effective in Antioxidant Treatment of Insulin Resistance and Vascular Function in an Obese Mice Model

(2020) Shailendra P. Singh et al.   Antioxidants

Cold Press Pomegranate Seed Oil Attenuates Dietary-Obesity Induced Hepatic Steatosis and Fibrosis through Antioxidant and Mitochondrial Pathways in Obese Mice

(2020) Marco Raffaele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice

(2020) Hsin Hsueh Shen et al.   Antioxidants

Positive Effects of Heme Oxygenase Upregulation on Adiposity and Vascular Dysfunction: Gene Targeting vs. Pharmacologic Therapy

(2019) Stephen J. Peterson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/ HO ‐1 and AMPK signalling pathways

(2019) Bingyu Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Insights on the Multifunctional Activities of Magnolol

(2019) Jianhong Zhang et al.   Biomed Research International

HO-1 overexpression and underexpression: Clinical implications

(2019) George S. Drummond et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis

(2018) Xiaojuan Wang et al.   FASEB JOURNAL

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma

(2018) Desirée Bartolini et al.   Translational Research

Magnolol Alleviates Inflammatory Responses and Lipid Accumulation by AMP-Activated Protein Kinase-Dependent Peroxisome Proliferator-Activated Receptor α Activation

(2018) Ye Tian et al.   Frontiers in Immunology

Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin

(2018) Yuji Ogawa et al.   Scientific Reports

Suppression of abdominal fat and anti-hyperlipidemic potential of Emblica officinalis: Upregulation of PPARs and identification of active moiety

(2018) Bhavesh C. Variya et al.   BIOMEDICINE & PHARMACOTHERAPY

APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice

(2017) Umakant Ashok Bahirat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells

(2017) Lin Wang et al.   Scientific Reports

Relevance of the NLRP3 Inflammasome in the Pathogenesis of Chronic Liver Disease

(2017) Xiaoqin Wu et al.   Frontiers in Immunology

Inhibiting autophagy promotes endoplasmic reticulum stress and the ROS-induced nod-like receptor 3-dependent proinflammatory response in HepG2 cells

(2016) Jia-Jing Yin et al.   Molecular Medicine Reports

Developmental origins of NAFLD: a womb with a clue

(2016) Stephanie R. Wesolowski et al.   Nature Reviews Gastroenterology & Hepatology

Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome

(2016) Nader G. Abraham et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet

(2016) Gabsik Yang et al.   Scientific Reports

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Activation of Nrf2/HO-1signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide-stimulated mouse RAW 264.7 macrophages

(2015) Sheng-Hua Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

Magnolol Reduced TNF-α-Induced Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells via JNK/p38 and NF-κB Signaling Pathways

(2014) Chan-Jung Liang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

NLRP3 inflammasome activation in d-galactosamine and lipopolysaccharide-induced acute liver failure: Role of heme oxygenase-1

(2013) Seok-Joo Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

NLRP3 inflammasome activation: CD36 serves double duty

(2013) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resveratrol Upregulates Nrf2 Expression To Attenuate Methylglyoxal-Induced Insulin Resistance in Hep G2 Cells

(2012) An-Sheng Cheng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease

(2012) Alexandra K. Leamy et al.   PROGRESS IN LIPID RESEARCH

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55

(2012) Viktor Rempel et al.   ACS Medicinal Chemistry Letters

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells

(2009) Sun-Sil Choi et al.   LIFE SCIENCES

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Pharmacological and Clinical Aspects of Heme Oxygenase

(2008) N. G. Abraham et al.   PHARMACOLOGICAL REVIEWS