CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR

(2020) Ping Yang et al.   FASEB JOURNAL

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis

(2020) Daqian Xu et al.   NATURE

Thrombospondin 1 improves hepatic steatosis in diet-induced insulin-resistant mice and is associated with hepatic fat content in humans

(2020) Jinyun Bai et al.   EBioMedicine

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway

(2019) Yun Li et al.   JOURNAL OF LIPID RESEARCH

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

(2019) Yamei Han et al.   Nature Communications

Cideb controls sterol‐regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites

(2019) Lu Su et al.   EMBO JOURNAL

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis

(2018) Lei Zhao et al.   JOURNAL OF HEPATOLOGY

Progress and challenges in the prevention and control of nonalcoholic fatty liver disease

(2018) Jingjing Cai et al.   MEDICINAL RESEARCH REVIEWS

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Endothelial cell CD36 optimizes tissue fatty acid uptake

(2018) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

(2017) Samir Softic et al.   JOURNAL OF CLINICAL INVESTIGATION

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

CD36 in chronic kidney disease: novel insights and therapeutic opportunities

(2017) Xiaochun Yang et al.   Nature Reviews Nephrology

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Circulating sCD36 levels in patients with non-alcoholic fatty liver disease and controls

(2016) S Heebøll et al.   INTERNATIONAL JOURNAL OF OBESITY

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

(2015) Chunming Cheng et al.   CANCER CELL

Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation

(2014) Dmitri Samovski et al.   DIABETES

Free Fatty Acid Uptake in Humans With CD36 Deficiency

(2014) Kazanna C. Hames et al.   DIABETES

A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid

(2014) Masanori Nakakuki et al.   JOURNAL OF BIOCHEMISTRY

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis inob/obmice

(2013) Fatiha Nassir et al.   JOURNAL OF LIPID RESEARCH

CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis

(2013) Robin D. Clugston et al.   JOURNAL OF LIPID RESEARCH

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits

(2010) Magdalena Szopa et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Insulin-induced gene: A new regulator in lipid metabolism

(2010) Xiao-Ying Dong et al.   PEPTIDES

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Cellular fatty acid uptake: a pathway under construction

(2009) Xiong Su et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

(2008) S Le Hellard et al.   MOLECULAR PSYCHIATRY