Betaine Alleviates High-Fat Diet-Induced Disruption of Hepatic Lipid and Iron Homeostasis in Mice

Betaine Supplementation Causes an Increase in Fatty Acid Oxidation and Carbohydrate Metabolism in Livers of Mice Fed a High-Fat Diet: A Proteomic Analysis

(2022) Caiyun Fan et al.   Foods

Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content via reversing the abnormal expression of MTTP and LDLR

(2021) Ping Chen et al.   Experimental and Therapeutic Medicine

Dietary Betaine Mitigates Hepatic Steatosis and Inflammation Induced by a High-Fat-Diet by Modulating the Sirt1/Srebp-1/Pparɑ Pathway in Juvenile Black Seabream (Acanthopagrus schlegelii)

(2021) Min Jin et al.   Frontiers in Immunology

Epigenetic Regulation of Peroxisome Proliferator-Activated Receptor Gamma Mediates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease

(2021) Tahar Hajri et al.   Cells

Integrated Transcriptomic and Translatomic Inquiry of the Role of Betaine on Lipid Metabolic Dysregulation Induced by a High-Fat Diet

(2021) Tengda Huang et al.   Frontiers in Nutrition

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

(2021) Han Zeng et al.   Molecular Metabolism

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

Fetal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in offspring cockerels with modification of promoter DNA methylation

(2020) Abdulrahman A. Idriss et al.   POULTRY SCIENCE

Increasing Fatty Acid Oxidation Prevents High Fat Diet Induced Cardiomyopathy through Regulating Parkin Mediated Mitophagy

(2020) Dan Shao et al.   CIRCULATION

Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease

(2020) Anne Fougerat et al.   Cells

Alleviative effect of Ruellia tuberosa L. on NAFLD and hepatic lipid accumulation via modulating hepatic de novo lipogenesis in high‐fat diet plus streptozotocin‐induced diabetic rats

(2020) Da‐Wei Huang et al.   Food Science & Nutrition

A high‐fructose diet in rats induces systemic iron deficiency and hepatic iron overload by an inflammation mechanism

(2020) Chao Wang et al.   JOURNAL OF FOOD BIOCHEMISTRY

MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36

(2020) Xin Wang et al.   Frontiers in Cell and Developmental Biology

Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet

(2019) Fan Zheng et al.   Lipids in Health and Disease

Iron-Induced Liver Injury: A Critical Reappraisal

(2019) Steven A. Bloomer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation

(2019) Nannan Zhao et al.   EUROPEAN JOURNAL OF NUTRITION

MiR-27a promotes insulin resistance and mediates glucose metabolism by targeting PPAR-γ-mediated PI3K/AKT signaling

(2019) Tianbao Chen et al.   Aging-US

Evolution of NAFLD and Its Management

(2019) Manpreet S. Mundi et al.   NUTRITION IN CLINICAL PRACTICE

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation

(2018) Yun Hu et al.   JOURNAL OF NUTRITION

Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats

(2018) Nannan Zhao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Betaine in Inflammation: Mechanistic Aspects and Applications

(2018) Guangfu Zhao et al.   Frontiers in Immunology

Pathways underlying iron accumulation in human nonalcoholic fatty liver disease

(2018) Elmar Aigner et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Long-Term High-Fat Diet Decreases Hepatic Iron Storage Associated with Suppressing TFR2 and ZIP14 Expression in Rats

(2018) Shuxia Jiang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation

(2017) Yun Hu et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Lower hepatic iron storage associated with obesity in mice can be restored by decreasing body fat mass through feeding a low-fat diet

(2016) Hak Chung et al.   NUTRITION RESEARCH

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

(2016) Yu-ming Chen et al.   Scientific Reports

Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet

(2015) Li Xu et al.   BRITISH JOURNAL OF NUTRITION

Pre-germinated brown rice prevents high-fat diet induced hyperglycemia through elevated insulin secretion and glucose metabolism pathway in C57BL/6J strain mice

(2015) Kuo-Ping Shen et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Betaine Protects Against High-Fat-Diet-Induced Liver Injury by Inhibition of High-Mobility Group Box 1 and Toll-Like Receptor 4 Expression in Rats

(2013) Wei Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

DNA Methylation in Oocytes and Liver of Female Mice and Their Offspring: Effects of High-Fat-Diet–Induced Obesity

(2013) Zhao-Jia Ge et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Diet-induced obese rats have higher iron requirements and are more vulnerable to iron deficiency

(2013) Jesse Bertinato et al.   EUROPEAN JOURNAL OF NUTRITION

Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet

(2013) Li-jun Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats

(2013) Rosaria Meli et al.   PLoS One

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron homeostasis in the Metabolic Syndrome

(2012) Christian Datz et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption

(2012) Thomas Sonnweber et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary fat level affects tissue iron levels but not the iron regulatory gene HAMP in rats

(2012) Umbreen Ahmed et al.   NUTRITION RESEARCH

Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis

(2012) Umbreen Ahmed   WORLD JOURNAL OF GASTROENTEROLOGY

Diet-induced obesity leads to decreased hepatic iron storage in mice

(2011) Jayong Chung et al.   NUTRITION RESEARCH

Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine

(2010) Elango Kathirvel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Berberine reduces methylation of theMTTPpromoter and alleviates fatty liver induced by a high-fat diet in rats

(2010) XinXia Chang et al.   JOURNAL OF LIPID RESEARCH

Betaine for nonalcoholic fatty liver disease: Results of a randomized placebo-controlled trial

(2009) Manal F. Abdelmalek et al.   HEPATOLOGY

Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet

(2009) Igor P. Pogribny et al.   JOURNAL OF HEPATOLOGY

Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload

(2008) Donatella Barisani et al.   JOURNAL OF HEPATOLOGY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY