Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice

Beneficial Activities of Alisma orientale Extract in a Western Diet-Induced Murine Non-Alcoholic Steatohepatitis and Related Fibrosis Model via Regulation of the Hepatic Adiponectin and Farnesoid X Receptor Pathways

(2022) Seung Ho Jeon et al.   Nutrients

Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease

(2022) Tobias Puengel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-bacterial effect of phytoconstituents isolated from Alimatis rhizoma

(2021) Chengfu Li et al.   Applied Biological Chemistry

A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease

(2021) Xiao-Han Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All-Trans Retinoic Acid (atRA) effectively improves liver steatosis in a rabbit model of high fat induced liver steatosis

(2020) Leila Zarei et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Retinoic acid receptor γ activation promotes differentiation of human induced pluripotent stem cells into esophageal epithelium

(2020) Yasufumi Koterazawa et al.   JOURNAL OF GASTROENTEROLOGY

Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders

(2019) William S. Blaner   PHARMACOLOGY & THERAPEUTICS

Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

(2019) Chiakang Ho et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pharmacological Activities of Alisma orientale against Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: Literature Review

(2019) Eunsol Choi et al.   Evidence-based Complementary and Alternative Medicine

Highly potent non-steroidal FXR agonists protostane-type triterpenoids: Structure-activity relationship and mechanism

(2019) Zhi-Lin Luan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Studies on the lipid-regulating mechanism of alisol-based compounds on lipoprotein lipase

(2018) Fei Xu et al.   BIOORGANIC CHEMISTRY

Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway

(2018) Chenqu Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

CD36 deficiency attenuates immune-mediated hepatitis in mice by modulating the proapoptotic effects of CXC chemokine ligand 10

(2018) Che Xu et al.   HEPATOLOGY

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

(2018) Takuma Tsuchida et al.   JOURNAL OF HEPATOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

(2018) Maria B. Goncalves et al.   NEUROBIOLOGY OF DISEASE

Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones

(2017) Caroline E Geisler et al.   JOURNAL OF ENDOCRINOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor

(2017) Yuichiro Kanno et al.   PHYTOMEDICINE

OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition

(2016) Shan-yao Ma et al.   ACTA PHARMACOLOGICA SINICA

Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation

(2016) Qiang Meng et al.   ACTA PHARMACOLOGICA SINICA

Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells

(2016) Lu Zeng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice

(2016) Liu Yao et al.   HEPATOLOGY

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review

(2014) Ting Tian et al.   JOURNAL OF ETHNOPHARMACOLOGY

All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade

(2013) Seong Chul Kim et al.   HEPATOLOGY

Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice

(2012) Hiroyuki Tsuchiya et al.   HEPATOLOGY

Retinoids counteract insulin resistance and liver steatosis: What's the potential mechanism?

(2012) Nadia Panera et al.   HEPATOLOGY

The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease

(2011) Jinhan He et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C

(2011) M. E. Miquilena-Colina et al.   GUT

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis

(2010) Francisco Caballero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY